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Mark Horowitz @markhoro.bsky.social Profile
Mark Horowitz @markhoro.bsky.social

@markhoro

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Trainee psychiatrist/Researcher @NELFT @UCLPsychiatry (honorary) . Maudsley Deprescribing Guidelines: https://t.co/MdD00q9Yd1 (US) https://t.co/9eUVpPj52p (UK)

London
Joined April 2013
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@markhoro
Mark Horowitz @markhoro.bsky.social
1 year
The Maudsley Deprescribing Guidelines is available in the UK US Australia Canada elsewhere around the world (also at other booksellers).
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@markhoro
Mark Horowitz @markhoro.bsky.social
9 hours
RT @danascullyshair: How it started How it continues
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@markhoro
Mark Horowitz @markhoro.bsky.social
9 hours
Well explained here.
@cwestonclark
Carrie Clark
10 hours
According to @markhoro, @sameerjauhar will publish an article tomorrow calling for antidepressant withdrawal to be deemphasised in clinical guidelines. This is a huge gut punch for those of us in the prescribed harm community who are trying to raise awareness about the risks of.
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@markhoro
Mark Horowitz @markhoro.bsky.social
12 hours
RT @EikoFried: Psychedelic science largely ignored problem of unblinding, dramatically inflating effect sizes (not even *assessed* in most….
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@markhoro
Mark Horowitz @markhoro.bsky.social
12 hours
It seems as usual I was too charitable and gave the benefit of the doubt too easily: the irrelevance of the short term studies that authors focused on was not highlighted. Instead they are calling for changes to guidelines to reflect that withdrawal is barely a thing. Disturbing.
@markhoro
Mark Horowitz @markhoro.bsky.social
2 days
Good to see Dr Jauhar's awareness of the general irrelevance of short term, drug company conducted studies in understanding the public health issue of high risk of withdrawal for millions of long-term users. Hope these measured thoughts will be in paper as well.
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@markhoro
Mark Horowitz @markhoro.bsky.social
15 hours
RT @atomicaceso: Sameer Jauhar’s pharma-backed paper dismissing antidepressant withdrawal based on short-term trials is academic gaslightin….
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@markhoro
Mark Horowitz @markhoro.bsky.social
15 hours
RT @_prescribedharm: Let's just sweep this under the rug for another 37 years.
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@markhoro
Mark Horowitz @markhoro.bsky.social
15 hours
RT @lizctucker: In my latest podcast @LauraDelano reveals the reality of being diagnosed as bipolar at just 14; the cocktail of drugs she w….
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@markhoro
Mark Horowitz @markhoro.bsky.social
16 hours
RT @petrie_caroline: @markhoro I don’t think I can take it, I remember the last round of Big Pharma push back, the minimising of harms and….
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@markhoro
Mark Horowitz @markhoro.bsky.social
20 hours
Deary me.
@JDaviesPhD
Dr James Davies (PhD) 💭
23 hours
We've now seen a preview of the forthcoming antidepressant withdrawal paper. It's shocking. On the basis of a few short-term company trials (mostly 8 weeks) the authors conclude that antidepressant withdrawal hardly exists! God help us if the media report this junk uncritically😳.
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@markhoro
Mark Horowitz @markhoro.bsky.social
1 day
More and more people are becoming aware of the trick being played on the public. Such an incredible amount of effort expended to save face, with such little regard for the effect on the health of so many people.
@ACE_CoalitionEd
Antidepressant Coalition for Education
1 day
Mark highlights a major flaw in much of the existing research on antidepressant withdrawal: it focuses primarily on short-term use. This is deeply problematic given that millions of people are now taking antidepressants long-term and the risk of severe, protracted withdrawal.
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@markhoro
Mark Horowitz @markhoro.bsky.social
1 day
The way this mess started was drug companies reporting mild and brief symptoms after 8-12 weeks of antidepressant exposure, ignoring escalating risks after longer term use. Imagine the chutzpah required to collect the same studies and declare the same finding in 2025.
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@markhoro
Mark Horowitz @markhoro.bsky.social
2 days
Good to see Dr Jauhar's awareness of the general irrelevance of short term, drug company conducted studies in understanding the public health issue of high risk of withdrawal for millions of long-term users. Hope these measured thoughts will be in paper as well.
@sameerjauhar
Sameer Jauhar
3 days
I do not have the ability to predict the future. Apparently some do. Reasonable point regarding length of studies. Happy to address this. I do not presume my work has relevance to anyone – that is their decision, not mine. Shanti.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
Data that underplays withdrawal mean that people who desperately need help are less likely to find it as policy makers are reassured by poor evidence 9/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
At some point we must surely move on from looking again and again at short term studies and pretending this has relevance to the millions of long term users 8/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
whilst ignoring the fact that people are driving around at 60km/hr on the road 7/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
So data from short term studies when there are millions of long term users (3 million + in the UK, 25 million + in the US, etc) is like a car company doing a safety test by crashing a car into a wall at 5km/hr and declaring it safe on impact,… 6/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
compares to this who use for less than 6 months. 5/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
We have shown that people who use antidepressants for > 2 years are 10 times more likely to experience withdrawal effects, 5 times more likely to report them as severe and 18 times more likely to have longer symptoms…. 4/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
Here is a sample of 11 industry conducted studies the authors of the new review have requested which generally go for 8-12 weeks: 3/n.
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@markhoro
Mark Horowitz @markhoro.bsky.social
3 days
The majority of published studies are short term studies conducted by the drug manufacturers. This is the same issue that beset the flawed Henssler review. 2/n.
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