Mark Horowitz @markhoro.bsky.social
@markhoro
Followers
12K
Following
10K
Media
146
Statuses
5K
Trainee psychiatrist/Researcher @NELFT @UCLPsychiatry (honorary) . Maudsley Deprescribing Guidelines: https://t.co/MdD00q9Yd1 (US) https://t.co/9eUVpPj52p (UK)
London
Joined April 2013
The Maudsley Deprescribing Guidelines is available in the UK US Australia Canada elsewhere around the world (also at other booksellers).
334
208
570
This statement is derived from studies of people who have been on the drugs for 8 weeks and in which severity was not measured and extrapolated to all users of antidepressants
0
1
1
RT @joannamoncrieff: 'Studying what happens to people after just eight to 12 weeks on antidepressants is like testing car safety by crashin….
0
26
0
RT @EllenBarryNYT: Comments are open on this piece on antidepressant withdrawal and a new analysis suggesting that withdrawal symptoms are,….
0
1
0
RT @joannamoncrieff: This thread highlights the severe limitations of the recent review of antidepressant withdrawal.
0
3
0
RT @JDaviesPhD: The New York Times were not taken in by the PR campaign pushing the new antidepressant study (a study mostly denying antide….
0
26
0
RT @joannamoncrieff: and note the only longer term trial (26 weeks) was of agomelatine, which seems to cause substantially less physical de….
0
2
0
press release 'presenting the data': "Now, this cutting-edge review clarifies the scientific evidence and should reassure all parties about the use, and discontinuation, of these treatments. Official guidance should now be changed to reflect the evidence."
They presented data from 8-12 week trials, concealed that in the paper (zero mention of length) and called for guidelines to be re-written in their press release for millions of long term users. That is not "just presenting data" Data here:
1
1
0
Dr Lewis “We do see supporting evidence for the experience of withdrawal symptoms after antidepressants are stopped. However, by the 12-month follow up, there’s very little evidence of a difference,” Only 12 months of withdrawal on average, no issue here!
2
2
11
They presented data from 8-12 week trials, concealed that in the paper (zero mention of length) and called for guidelines to be re-written in their press release for millions of long term users. That is not "just presenting data" Data here:
As before, incorrect. Just presenting data. Polarisation is wrong, in any context. See what you think of the paper. Regards, Sameer.
2
3
10
Concluding that depressed mood following antidepressant withdrawal was relapse "could lead clinicians to neglect or misjudge these symptoms, leading to longer-than-needed use of medication for some patients."
0
3
8
In the NYT, academics, some of whom have been paid by companies that market these drugs, say that patient concern about withdrawal was caused by a 2019 review of withdrawal and is manufactured
4
5
17
RT @ReadReadj: Antidepressant withdrawal: new review downplays symptoms but misses the mark for long-term use via @….
0
6
0
Very common story - delayed onset withdrawal effects often occur.
@markhoro I can't access the full paper. It says in the summary that this was looking at symptoms after 1 week off the medication. Is that correct? It seems like a massive limitation. The first week off the drugs for me was relatively mild compared to how I was a few months later.
1
1
18
The review by Kalfas on antidepressant withdrawal in JAMA Psychiatry will mislead as it is based largely on people who have taken antidepressants for 8-12 weeks in 11 RCTs-this will under-estimate the risks for millions of long-term users. Thread (1/n)
0
0
1
"Scientists accused of downplaying dangers of antidepressants"
0
12
39
RT @KyCryxpto: @sameerjauhar “Presenting the data” that you know full well is compromised like that in the Antler trials by misclassifying….
0
2
0
When denial of the issue is no longer tenable they turn to minimisation and underplaying. See @ConversationUK article here: (31/n).
1
0
7
It is hard not to think of Naomi Oreskes book ‘Merchants of Doubt’ in which she outlines how academics backed by industry have set out to deny, obscure and minimise health and environmental issues, including links between smoking and cancer. (30/n).
1
0
5
This may have the effect of diminishing the already paltry efforts by the health system to help 10,000s of people who are suffering and much greater numbers at risk of serious issues. (29/n).
1
0
3