Tris Dyson @Challenge_Works discusses his diagnosis of ALS, the case for using a prize to spur innovation, and the potential for leveraging AI to find treatments for the disease. @GlobalGenes #RARECast.

Stacey Adam @FNIH_Org discusses the public-private partnership she is leading to advance alternatives to animal testing, the technologies they are exploring, and their potential to accelerate drug development.

What do you want to know?.

Daniel Fischer of @TevardB discusses his journey as the parent of a child with a rare disease, how it led to his co-founding Tevard, and its pursuit of tRNA therapies that may treat a range of diseases with a single medicine. @GlobalGenes #RARECast.

Dimitris K. Agrafiotis, Director of Digital Analytics and AI at Arsenal Capital Partners discusses why AI will have a bigger near-term impact on improving operational overhead than on driving novel science.

Lorin Johnson of Glycyx discusses the effect of opioids on the immune system and the company’s experimental therapy designed to mitigate the negative effects of opioids in cancer patients being treated with checkpoint inhibitors.

Tien Lee, CEO of Aardvark Therapeutics, discusses Prader-Willi syndrome, the biological difference between hunger and appetite, and why his company’s experimental therapy may have broader applications in other forms of obesity. @GlobalGenes #RARECast.

.@AbbasRKazimi @NimbusTx, discusses how the company’s drug discovery approach has evolved with AI, its deal making successes, and how its business model provides liquidity to investors and while making it easier to structure deals.

Here's what you may have missed in July from The Bio Report, RARECast, Life Sciences D'n'A, and MitoCast podcasts.

David Goldstein @actiobiosci discusses the company’s rare-to-common business model, how it identifies the indications it will pursue, and why pricing may represent a challenge. @GlobalGenes #RARECast .

Juho Jalkanen @FaronPharm discusses how the tumor microenvironment can suppress macrophages, how the company’s macrophage checkpoint inhibitor works, and the challenges a Finland-based company faces accessing the capital markets.

.@NASA PIs @mason_lab and @AfshinBeheshti discuss the impact of space travel on mitochondria, why it represents a critical barrier for space travel, and why solving the problem may give us ways of extending healthy years of life on Earth.

Khartik Uppalapati, co-founder of the RareGen Youth Network, discusses his journey as a rare disease patient, his work as an advocate, and why it's essential there be greater youth representation in healthcare policy and advocacy. @GlobalGenes #RARECast.

Sunil Talathi of @BeOneMedicines sits down with Nagaraja Srivatsan to discuss his experience implementing AI in a biopharmaceutical company, prompt engineering, and the need for collaboration between humans and AI systems.

.@BioUsawa and @ServareGMP announced a strategic partnership to establish advanced monoclonal antibody manufacturing capabilities in Africa, directly addressing the critical healthcare access gap affecting patients in low- and middle-income countries.

Arun Upadhyay @Ocugen discusses inherited retinal diseases, the company’s gene therapies that can work across different genetic mutations, and the potential of its platform technology beyond the eye. @GlobalGenes #RARECast.

Jenny Marlowe and Melissa Bonner of @nchromabio discuss the company’s experimental epigenetic editor for hepatitis B, the merger that formed the company, and how it married an epigenetic editing platform with programmable non-viral delivery technologies.

Steve Mahoney @ViridianThera discusses thyroid eye disease, the challenges of living with the condition, and why its veligrotug has the potential to provide a new alternative for people living with the condition. @GlobalGenes #RARECast.

.@Niven_Narain , CEO of BPGbio, discusses how the company’s platform technology uncovers novel targets, its evolution from its start as Berg, and how the platform continues to provide insight into experimental therapies after they advance to the clinic.

Traci Davies and her son Ben Davies both discuss their experiences with primary immunodeficiency, what it’s like to be both a caregiver and patient, and why they have both become patient advocates. @GlobalGenes #RARECast.

Melanie Kandzierski discusses how she has learned to care for a child with Dravet syndrome, care for herself, and to advocate not only for her child but others with complex medical conditions. @GlobalGenes #RARECast.