LiverTox
@livertox
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Experts interested in all things Hepatotoxicity. Opinions expressed here are those of the collective DILIN investigators, and not the NIH #livertwitter
Bethesda MD
Joined July 2022
#livertwitter #GItwitter colleagues please refer suspected HDS and DILI cases to DILIN #dili #livertox # hepatotoxicity. Study helps unravel mechanisms; new causality tools (RECAM). 6 sites across the US:
dilin.org
Indiana University-Purdue University of Michigan-Ann Arbor University of North Carolina-Chapel Hill Atrium Health Wake Forest Baptist University of Southern California University of California-Los …
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Fall is in the air and it's time for The Liver Meeting! #TLM2025 @AASLDtweets DILIN Investigators will be in DC and we are excited to share some of our most recent research. Hope to see you all there!
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What defines success in a Clinical Research Network? From the great Jay Hoofnagle at the #DILIN meeting - Elucidate pathogenesis of disease - Place findings in public domain - Stimulate research - Decrease morbidity and mortality of dz - Publications are not the end game
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New DILIN publication alert by esteemed Investigator Dr. Paul Watkins using blood-based transcriptomic biomarkers to aid in the diagnosis and prognosis of idiosyncratic #DILI
https://t.co/POdSmaH00J
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Early experience with resmetirom to treat MASH by @IUGastro
https://t.co/IEaAc23PFX -High d/c rate due to GI AEs -Need close f/u early to manage GI AEs -Certainly not "prescribe & forget" like DAAs @MadrigalPharma @rajVuppaLanchi @AlkhouriNaim @MazenNoureddin @ebtapper
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A very nice review of DILI in patients with underlying CLD.
📚 This #ManuscriptMonday, check out Drs. Ghabril, Vuppalanchi, & @nagachalasani’s review! #LiverTwitter @LiverInt 💊 DILI from meds & supplements 🏥 CLD patients are at higher risk ⚠️ Can lead to acute-on-chronic liver failure 🔗 https://t.co/iNyDdU2I2i
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DILI harms patients and remains a TOP reason drugs are withdrawn from the market. Recommend this article by @nagachalasani et al in @HEP_Journal reviewing preclinical and clinical testing, DILI adjudication during trials, and how regulators approach NDAs.
journals.lww.com
lves a multitude of in vitro assays and in vivo animal experiments before a compound is moved into first-in-human phase 1 testing. Over the last 2 decades, there have been a number of advances in...
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Did you know that selective androgen receptor modulators, anabolic steroids and some body building supplements can cause #DILI ? Patients display cholestasis +/- pruritus. Tomorrow 11am EDT/8am PDT @AASLDtweets HepTox SIG is hosting Drs. Andrew Stolz and @DavidKleiner12 who will
✌️ days away! Register today to join presenters Andrew Stolz, MD, and David Kleiner, MD, PhD, for a case-based discussion on a 36-year-old male with prolonged cholestatic liver injury associated with renal impairment due to anabolic steroid use. https://t.co/UOWcZ0t2RN
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What makes you tip over from liver injury to ALF? We are honored to host Dr. Bryan Copple tomorrow for the @AASLDtweets Hepatotoxicity SIG seminar. @wxding1 @livertox To join us register for a link:
Join us this Thursday, March 13, for an in-depth discussion on the progression from acute liver injury (ALI) to acute liver failure (ALF), with a focus on the role of hepatic vasculature damage and immune modulation. Register today: https://t.co/3rF7kCd377
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Interesting seminar on the effect of environmental toxins on the liver #hepatotoxicity
Join us tomorrow for our February webinar, Toxic Relationships: When Liver Meets Industrial Chemicals. Learn about the impact of VOCs, PFAS, metals, microplastics, and more on liver health. Register now: https://t.co/Hwi8hXaE2K
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#livertwitter @AASLDtweets Hepatotoxicity SIG Seminar this Thursday by Dr. Grace Guo
We are honored to host Dr. Guo this month. Register here: https://t.co/f1Z3Uw14qX
@TFFVIIa @wxding1 @DrPMonga
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We often overlook the hepatotoxicity of environmental toxicants. Timely presentation from Dr. Julianne Beier @ArteelBeier on the impact of PFAS, microplastics and organic pollutants on the liver! Register below
🚨 New Webinar Alert 🚨 The February webinar, Toxic Relationships: When Liver Meets Industrial Chemicals, will cover the effect of volatile organic compounds, PFAS, metals, persistent organic pollutants, and emerging toxicants (microplastics) on the liver. https://t.co/Hwi8hXaE2K
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Predicting drug-induced liver injury during drug development will decrease he burden of DILI. Investigators from @PLRC_PittLiver are presenting their work on human biomimetic micro physiologic systems at the next @AASLDtweets Hepatotoxicity seminar. Registration link here:
Join us this Thursday Jan 9th 11am EST/8amPST @AASLDtweets #Hepatotoxicity SIG seminar " Using human biomimetic liver microphysiology system and quantitative systems toxicology models to study MASLD and DILI" presented by Drs. Vernetti & Miedel, from @PLRC_PittLiver Register
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🌿 Exciting insights from Dr. Ghabril at the packed @aasldtweets "Wait, Wait...Don't DILI!" session! He discussed emerging causes of Drug-Induced Liver Injury (#DILI), highlighting the role of Withania somnifera (ashwagandha). 💡 #LiverTwitter #TLM24
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Kudos to @RobertFontanaMD and @jonnysexton for pulling off a very successful Hepatotoxicity SIG session on organoids at #tlm2024! Cutting edge tools to study liver disease and DILI! @AASLDtweets
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Had to go to overflow at the Hepatotoxicity SIG’s “wait! Wait! Don’t DILI” to avoid being cited by the fire Marshalls! 😂🔥 great success and lots of silly fun, thanks to the amazing Jim Luyendyk @TFFVIIa @AASLDtweets
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Opportunity to connect with friends and colleagues attending @AASLDtweets #TLM2024 from across the globe. DILI investigators meet #TLM24 @nagachalasani @bjornsson_s
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Back by popular demand! Join us to win a prize and bragging rights 👉Sunday 11/17/24 9:45am Ballroom 6D "We wanted to do something silly, With a nod from AASLD, really! Don’t let this pass by, Or Jim might just cry, Welcome to Wait, Wait, Don’t....." @TFFVIIa @AASLDtweets
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You don’t need to know each detail Just know prizes may land in your email Whether he knows it or not David Kleiner’s your bot If you win, he records your new….voicemail Also there are coffee mugs. 😁 @DavidKleiner12 @AASLDtweets See you all at Wait Wait…
Back by popular demand! Join us to win a prize and bragging rights 👉Sunday 11/17/24 9:45am Ballroom 6D "We wanted to do something silly, With a nod from AASLD, really! Don’t let this pass by, Or Jim might just cry, Welcome to Wait, Wait, Don’t....." @TFFVIIa @AASLDtweets
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