Leshchiner Lab
@lesh_lab
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Joined April 2022
RT @BUMedicine: BU researchers show that unexpected multiple independent lung tumors in a single patient may be caused by developmental som….
nature.com
Nature Cancer - Burr et al. analyze multiple primary EGFR-mutant lung tumors from ten patients and define developmental mosaicism as a mechanism underlying multiple tumor presentation in this setting.
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patient can result from developmental somatic mosaicism in the adult lung. This occurs when only some normal cells in the body carry shared mutations, including a driver EGFR mutation. Congratulations to all co-authors on this study!.
nature.com
Nature Cancer - Burr et al. analyze multiple primary EGFR-mutant lung tumors from ten patients and define developmental mosaicism as a mechanism underlying multiple tumor presentation in this setting.
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Our paper "Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors" is out in Nature Cancer today. With lineage tracing and phylogeny analysis by PhylogicNDT we show that, unexpectedly, multiple independent lung tumors in a single 🎉
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RT @NEBiolabs: Two more golden butterflies were caught at the Festival of Genomics & BioData in Boston! Stop by the New England Biolabs boo….
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Thank you so much to the The Karen Toffler Charitable Trust for their generous support!.
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We are profiling circulating nucleic acids in the blood to identify biomarkers of Alzheimer’s subtypes that are common in solid tissue, cerebrospinal fluid and blood to develop a blood-based assay to detect and monitor Alzheimer’s disease.
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Alzheimer’s disease encompasses distinct subtypes that are challenging to detect and differentiate during an individual’s lifetime, often limiting treatment strategies to symptom management.
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Honored, excited and grateful to be named 2024 Toffler Scholar! The Toffler Scholar program supports promising young medical researchers, physicians, and scientists in leading universities who are at a pivotal point in their careers.
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Adipocytes adjacent to the tumor have been known to alter their secretion patterns in conditions of obesity and insulin resistance, also altering the content of exosomes they shed to the blood stream. Thank you to the Dahod family for their generous support!.
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Population studies reveal that women with comorbidities like obesity and diabetes face an increased risk of distant metastases in breast cancer.
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Honored and grateful to receive the 2024 Dahod Award in Breast Cancer for our collaboration with Dr. Gerald Denis on the mechanisms of diabetic exosome induced reprogramming of tumor cells that increase metastatic potential of breast cancer.
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Huge congratulations to Liz !.
🇺🇸 Mary Wilson and Elizabeth Martin take home silver in the lightweight women’s double sculls at the 2023 Pan American Games. 1. CHI - 7:11.70🥇.2. USA - 7:14.54🥈.3. ARG - 7:15.27🥉. #Santiago2023 @TeamUSA.
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We are very excited to welcome Tayeb Jamali as a new postdoc in the lab!
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We are very excited to welcome Eli Lichter as a new postdoc in the lab!
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RT @NatureCancer: 💫DON’T MISS @NatureCancer “Inferring early genetic progression in cancers with unobtainable premalignant disease” by @get….
nature.com
Nature Cancer - Getz and colleagues demonstrate a computational approach to estimate the timing of genomic drivers in early tumor progression from cancer types that do not have premalignant...
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