leishomicspapers
@leishomicsbot
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I'm a robot who tweets about Leishmania -omics papers, fed to me from PubMed and bioRxiv. Run by @jamesacotton
Joined December 2021
Inter-individual and inter-regional variability of breast milk antibody reactivity to bacterial lipopolysaccharides
pubmed.ncbi.nlm.nih.gov
Breast milk is a vital source of nutrients, prebiotics, probiotics, and protective factors, including antibodies, immune cells and antimicrobial proteins. Using bacterial lipopolysaccharide arrays,...
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Promotion of order Bunyavirales to class Bunyaviricetes to accommodate a rapidly increasing number of related polyploviricotine viruses
pubmed.ncbi.nlm.nih.gov
Prior to 2017, the family Bunyaviridae included five genera of arthropod and rodent viruses with tri-segmented negative-sense RNA genomes related to the Bunyamwera virus. In 2017, the International...
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Integrated subtractive genomics and structure-based approach to unravel the therapeutic drug target of Leishmania species
pubmed.ncbi.nlm.nih.gov
Leishmaniasis is a complex vector-borne disease caused by intracellular protozoan parasites of the Leishmania genus. It presents a significant public health challenge in tropical and subtropical...
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Spectrum of bacterial pathogens in inflammatory and noninflammatory cutaneous ulcers of American tegumentary leishmaniasis
pubmed.ncbi.nlm.nih.gov
The distribution of flora did not differ between inflammatory and noninflammatory CL phenotypes. Further prospective analysis, including additional WGS studies of all CL ulcers for nonbacterial...
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Recent development in CRISPR-Cas systems for human protozoan diseases
pubmed.ncbi.nlm.nih.gov
Protozoan parasitic diseases pose a substantial global health burden. Understanding the pathogenesis of these diseases is crucial for developing intervention strategies in the form of vaccine and...
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Abundance and Leishmania infection patterns of the sand fly Psathyromyia cratifer in Southern Mexico
pubmed.ncbi.nlm.nih.gov
This is the first contribution ever made to both the population dynamic and the temporal Leishmania prevalence patterns in Psathyromyia cratifer. The resulting findings suggest that this sand fly...
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Leishmania amazonensis-derived extracellular vesicles (EVs) induce neutrophil extracellular traps (NETs)
pubmed.ncbi.nlm.nih.gov
Neutrophils interact with Leishmania when the sandfly vector inoculates these parasites in the host with saliva and promastigotes-derived extracellular vesicles (EVs). It has been shown that this...
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Leishmania spp. genetic factors associated with cutaneous leishmaniasis antimony pentavalent drug resistance: a systematic review
pubmed.ncbi.nlm.nih.gov
The development of further studies to evaluate the genetic resistance factors of Leishmania spp. is necessary to elucidate the mechanisms of the parasite and improve patient treatment and infection...
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Comparative genomics uncovers the evolutionary dynamics of detoxification and insecticide target genes across 11 phlebotomine sand flies
pubmed.ncbi.nlm.nih.gov
Sand flies infect more than 1 million people annually with Leishmania parasites and other bacterial and viral pathogens. Progress in understanding sand fly adaptations to xenobiotics has been...
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Improved high quality sand fly assemblies enabled by ultra low input long read sequencing
pubmed.ncbi.nlm.nih.gov
Phlebotomine sand flies are the vectors of leishmaniasis, a neglected tropical disease. High-quality reference genomes are an important tool for understanding the biology and eco-evolutionary...
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Emerging Leishmania donovani Lineages Associated with Cutaneous Leishmaniasis, Himachal Pradesh, India, 2023
pubmed.ncbi.nlm.nih.gov
The clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence of novel Leishmania lineages has caused atypical pathologi...
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Autochthonous Leishmaniasis Caused by Leishmania tropica, Identified by Using Whole-Genome Sequencing, Sri Lanka
pubmed.ncbi.nlm.nih.gov
Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L....
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Transcriptome and proteome changes triggered by overexpression of the transcriptional regulator Maf1 in the human pathogen Leishmania major
pubmed.ncbi.nlm.nih.gov
Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across eukaryotes. However, the knowledge about Maf1 in protozoan...
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Clickable Probes for Pathogen Proteasomes: Synthesis and Applications
pubmed.ncbi.nlm.nih.gov
The 20S proteasome is a multimeric protease complex that is essential for proteostasis in the cell. Small molecule proteasome inhibitors are approved drugs for various cancers and are advancing...
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On the PhyloQuant protein expression profiles approach to the taxonomic problem
pubmed.ncbi.nlm.nih.gov
Inferring evolutionary relationships among organisms has been a fundamental problem in evolutionary biology. The current phylogenetic molecular methods serve as the baseline model to test new...
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Discovery of essential kinetoplastid-insect adhesion proteins and their function in Leishmania-sand fly interactions
pubmed.ncbi.nlm.nih.gov
Leishmania species, members of the kinetoplastid parasites, cause leishmaniasis, a neglected tropical disease, in millions of people worldwide. Leishmania has a complex life cycle with multiple...
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Design, Synthesis, and In Vitro and In Silico Evaluation of 1,3,4-Oxadiazoles as Anti-Trypanosoma cruzi and Anti-Leishmania mexicana Agents
pubmed.ncbi.nlm.nih.gov
A series of novel 4-acetyl-1,3,4-oxadiazole derivatives was designed and synthesized for their biological evaluation in vitro against Trypanosoma cruzi (T. cruzi) and Leishmania mexicana (L. mexica...
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Analysis of HLA Alleles in Different Cohorts of Patients Infected by L. infantum from Southern Spain
pubmed.ncbi.nlm.nih.gov
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania, which is endemic in certain areas of Europe, such as southern Spain. The disease manifests in various clinical...
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Interplay between DOT1L and HDAC1 regulates Leishmania donovani infection in human THP-1 cells
pubmed.ncbi.nlm.nih.gov
Leishmania donovani, a protozoan parasite, causes visceral leishmaniasis. The parasite modifies the global gene expressions of the host genome, facilitating its survival within the host. Thus, the...
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CO-EXPRESSION OF HUMAN SIALYLTRANSFERASE IMPROVES N-GLYCOSYLATION IN Leishmania tarentolae AND OPTIMIZE THE PRODUCTION OF HUMANIZED THERAPEUTIC GLYCOPROTEIN IFN-BETA
pubmed.ncbi.nlm.nih.gov
The production of therapeutic glycoproteins is primarily expensive due to the necessity of culturing mammalian cells. These systems often require complex and costly culture media and typically yield...
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