leadXpro
@leadxpro
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Structural Biology of Membrane Proteins
Joined September 2017
Our LptDE paper finally got published in Nature Communications, 13, 1826 (2022). Here is the link to the article:. A short blog story written for Nature:. And the link to our previous news story:.
communities.springernature.com
Bacteria display very different biochemistry from human cells, which can be exploited for designing new antibiotics with less side-effects. Detailed insights into the architecture and function of...
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How are progresses in #AI and #structuralbiology impacting drug discovery? Find out in our latest article where we highlight advancements in five fast-growing techniques:.
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leadXpro has a new website! —> Here you can explore our scientific developments, evolving pipeline and fantastic partnerships. We want to take this opportunity to thank all of our supporters, who have contributed to our success over the last 6 years.
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leadXpro reports the first structure of the human Kv3.1 channel, solved at 2.6 Å by cryo-EM, in the apo state and in complex with a ligand from our collaborators at Lundbeck. The structure of this important CNS drug target reveals a novel binding-site for positive modulators.
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Binding partners are essential tools for structure research. leadXpro has patented “Pro-Macrobodies” or PMbs, novel proteins that fuse target-specific nanobodies with a maltose-binding protein via a rigid linker. The rigid linker was optimized using molecular dynamics simulations
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The remarkable gymnastics of β-barrel outer membrane proteins. The lateral opening of lipopolysaccharide (LPS) transporter LptD, as seen by cryoEM, hints at how LPS is released into the bacterial outer membrane. Find out more at:
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leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane.
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Dr. Michael Hennig, CEO at leadXpro, will be giving a webinar at Symeres, Thursday March 11th at 6 PM CET (9 AM PT). Register here:.
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Today, leadXpro is celebrating it’s 5th anniversary! 🥳🎂🎉. A huge thank you to everyone who has supported the company, from start-up to industry leader. Thanks to this, we have produced more than 40 novel ligand-complexed X-ray and cryo-EM structures of membrane proteins.
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Axxam S.p.A, leadXpro AG and MercachemSyncom announce a strategic alliance for world-class integrated structure-guided drug discovery services for membrane protein targets. #drugdiscovery #drugdevelopment #discovery #chemistry #biology #medchem.
lnkd.in
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First Cryo-EM structure of the agonist complexed human TRPV4 ion-channel in the open-conformation
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RT @reducentropy: 2.6 Å structure multidrug & toxic comp extrusion transporter .could aid design of optim pharmacokinetic drug profiles.htt….
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RT @reducentropy: Light controlled membrane channel high res structures .#optogenetics workhorse channelrhodopsin 2.://goo.gl/FFsnwW https:….
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RT @reducentropy: Relationship of receptor gymnastics with transmembrane signalling:.biological function arising from time & length domains….
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