Guo Lab (Sheffield)
@lab_guo
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The Guo Lab aims to understand the basic cell stress mechanisms associated with protein post-translational modifications in Health and Disease
Sheffield, England
Joined June 2019
To meet, learn and discuss: an exciting meeting for sure š https://t.co/NQg6Itw6dz
protein-degradation.org
Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation.
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https://t.co/PiPMI5AJWp EMBO Workshop SUMOylation: From discovery to translation 22 ā 25 September 2025 | La Grande Motte, France I am sure this will be a good oneš.
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This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.
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For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.
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'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a ļ¬ne-tuning regulator.'
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New Primary Research Publication from This Lab: 'SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia' https://t.co/J4AAEcww4m
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Happy to be part of the team š„° " ... C.G. first identified MFF as a SUMO substrate. . All authors contributed to editing the manuscript." Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission https://t.co/zhpLR7Jgsl
science.org
A key molecular step is identified for the fragmentation and removal of damaged mitochondria that is essential for cell health.
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SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided). https://t.co/VzUdo6D6mS
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"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways." https://t.co/3YOfAFTOR5
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Collaboration between the mitochondria and the nuclei in protein making https://t.co/B80Z8hl72R
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The University of Sheffield Reviews by students https://t.co/u2npq1BdmC
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Chronic but not acute nicotine treatment ameliorates acute inflammationāinduced working memory impairment by increasing CRTC1 and HCN2 in adult male mice - Wang - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library
onlinelibrary.wiley.com
LPS significantly induced WM deficit accompanied by the increase in IL-1Ī² and TNF-Ī± in mPFC. Nicotine treatment significantly alleviated LPS-induced WM deficit by upregulating CREB-regulated transc...
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SENP3 againāļø š§ "In Alzheimerās disease (AD), the BLA base model 654 identified seven AD-associated genes (DTX1, C3orf37, MEX3C, INPP1, USP32, YPEL2, SENP3)" https://t.co/eGqs9RF7bF
biorxiv.org
To explain why individuals exposed to identical stressors experience divergent clinical outcomes, we determine how molecular encoding of stress modifies genetic risk for brain disorders. Analysis of...
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