Guo Lab (Sheffield)
@lab_guo
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The Guo Lab aims to understand the basic cell stress mechanisms associated with protein post-translational modifications in Health and Disease
Sheffield, England
Joined June 2019
To meet, learn and discuss: an exciting meeting for sure š .
protein-degradation.org
Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation.
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EMBO Workshop.SUMOylation: From discovery to translation. 22 ā 25 September 2025 | La Grande Motte, France. I am sure this will be a good oneš.
meetings.embo.org
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins ā¦
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This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.
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For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.
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'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a ļ¬ne-tuning regulator.'.
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New Primary Research Publication from This Lab: .'SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia'.
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Happy to be part of the team š„°." . C.G. first identified MFF as a SUMO substrate. All authors contributed to editing the manuscript.".Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission.
science.org
A key molecular step is identified for the fragmentation and removal of damaged mitochondria that is essential for cell health.
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SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided).
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MiDs - MFF - DRP1 actions in mitochondrial fission.
nature.com
Nature Cell Biology - We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA binds in a previously identified pocket located within...
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"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways.".
nature.com
Nature Methods - Combining genome-wide CRISPRāCas9-mediated base editors with temporally resolved phosphoproteomics enables the functional screening of thousands of post-translational...
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Collaboration between the mitochondria and the nuclei in protein making .
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Chronic but not acute nicotine treatment ameliorates acute inflammationāinduced working memory impairment by increasing CRTC1 and HCN2 in adult male mice - Wang - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library
onlinelibrary.wiley.com
LPS significantly induced WM deficit accompanied by the increase in IL-1Ī² and TNF-Ī± in mPFC. Nicotine treatment significantly alleviated LPS-induced WM deficit by upregulating CREB-regulated transc...
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SENP3 againāļø š§."In Alzheimerās disease (AD), the BLA base model.654 identified seven AD-associated genes (DTX1, C3orf37, MEX3C, INPP1, USP32, YPEL2, SENP3)".
biorxiv.org
To explain why individuals exposed to identical stressors experience divergent clinical outcomes, we determine how molecular encoding of stress modifies genetic risk for brain disorders. Analysis of...
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