🚨Fully-funded PhD/Postdoc positions available!🎓🔬 The Gad Asher Lab @WeizmannScience is currently looking for motivated and curious minds to join us! Find out more about us: https://t.co/XlbtpuRp1J 🔁 Please RT! #PhD #PhDposition #Postdocposition

New research from @lab_asher at the Weizmann Institute of Science reveals that sex hormones reset our internal clocks. The study, published in @NatureComms, offers new insights into circadian disruption during menstruation, pregnancy & menopause >> https://t.co/CjW6EPV6TF

Happy Hanukkah from the Gad Asher Lab, Chag Sameach! @WeizmannScience

Huge thanks to everyone behind this paper, it would not have been possible without your efforts!! 9/End

How may CRY2 mediate serum effect on clock? We found that CRY2 interacts with glucocorticoid receptor and acts as an activator of glucocorticoid signaling. 8/

Which clock component mediates the resetting signal to the clock? We knocked down the negative arm of the clock machinery (Per1/2 and Cry1/2), and found Cry2 knockdown, but not others, changed the clock response to serum, suggesting it plays a role. 7/

Blocking glucocorticoid, progesterone, and estrogen receptors together completely eliminated serum-induced clock resetting, showing steroid hormone receptors drive most of the serum response. 6/

Because serum contains steroid hormones that could mask other signals, we repeated the screen with mifepristone (MF). Some inhibitors (ER, AMPK) acted synergistically with MF, others (Src, Rho/MLK1/SRF, PI3K) opposed it. 5/

We treated cells with rat serum,a strong resetting cue, plus 25 pathway inhibitors.If an inhibitor changed serum’s resetting effect, that pathway likely links serum signals to the clock.We found c-Myc, AhR, Androgen Receptor, among others, as strong modulators of the serum PTC.4/

Studying clock resetting is hard — you must track each cell’s clock before and after treatment to build Phase Transition Curves. @GalManella developed Circa-SCOPE, a clever way to construct PTCs in bulk. This let us screen which pathways are responsible for resetting the clock.3/

Most cells keep their own molecular clock. But how do they stay aligned with the environment and with each other? We’ve long known that blood carries cues that reset the clock, yet the link between these blood-borne signals and the clock’s core machinery in cells was unclear. 2/

We are happy to announce our new publication in Nature Communications led by @GalManella, @SaarEzagouri_RD , and @Nitya0602 ! https://t.co/KKaw7rLdkA Here’s a quick overview of the main findings → 1/🧵

Shana Tova!

We are delighted to welcome our new member, Shira! Together we shall explore new horizons in clock biology.

Check out our new book chapter with our collaborator Xianlin Han: Lipidomic Profiling of Isolated Nuclei from Mice and Cultured Cells https://t.co/s94wgMiWPu

Amid challenging times, we’re happy to share some good news: our incredible lab manager, Marina, has worked tirelessly to launch our brand-new website. It’s finally live, check it out! https://t.co/tFU06ivy3c

🚨Fully-funded PhD/Postdoc positions available!🎓🔬 The Gad Asher Lab @WeizmannScience is currently looking for motivated and curious minds to join us! Find out more about us: https://t.co/XlbtpuRp1J 🔁 Please RT! #PhD #PhDposition #Postdocposition

At Gad Asher lab, we don't just do science with 120% dedication... we also enjoy hosting the BEST departmental social hour ever (won't apologize for it)! This time, we turned 6kg of rice into >200 Onigiris 🍙 and had 120 Mochi ice creams! Co-hosted with Yoav Soen lab!

Congratulations @Nitya0602 for his STAR protocol paper! In this protocol, we describe how to use contrast echocardiography to monitor intrapulmonary vasodilation in mice 🐭 https://t.co/35iHNKyWCs

Congratulations to Nitya @Nitya0602 for receiving the short talk prize at the Indian society for chronobiology meeting #CRHD2024!! We are so proud of you!!

Our recent work was highlighted here by Weizmann science news! :)