Eric Kool
@koolchemistry
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Joined January 2015
Excited that our paper on RiboLight (RL) dyes has been published - new multicolor dyes that are RNA-specific. They work great in live cells and in gels- https://t.co/WYNnazC2Qw
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thanks also to our collaborators at NIST - Pawel Jaruga & the late Miral Dizdaroglu. Hope NIST researchers can get back to work soon
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We all know that DNA damage in our cells is undesirable - but how about in our food? Postdoc Jinwoo Shin's study shows high levels of damage in the DNA of some cooked foods and suggests that eating it may be a hazard to us- https://t.co/GXVw9VDjCU
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thanks also to Jayanta Kundu and "Mano" Manoharan at Alnylam for collaborating on this!
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It turns out that pseudouridines stabilize RNA markedly by having less nucleophilic 2'-OH groups - congrats to Dipanwita Banerjee on leading this work! https://t.co/p1Nb2tVm8r
pubs.acs.org
Nucleotides with a carbon substitution for heteroatoms are common in biological and therapeutic RNAs. Important examples include the C-nucleosides pseudouridine and N1-methylpseudouridine; these...
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Also had the privilege of speaking at the Samsung Global Research Symposium on Chemical Biology a few days ago in San Diego - it was packed with exciting new research. A belated thanks to @Samsung
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I attended and spoke at the ACS Western Regional meeting this weekend - thanks to @ByronPurse for the invitation and for organizing a fun session on nucleoside and nucleic acids chemistry!
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Using a DNA-catalyst conjugate to place aryl groups at specific sequences in RNA - Congrats to Sumon Pratihar for leading the work! https://t.co/3NE9DBUwQy
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New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method- Great work by Linglan Fang and Wenrui Zhong in developing this! https://t.co/KmoQFApM8w
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...so I asked it to change it to a right-handed turn and the result was suboptimal
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after criticizing the accuracy of DNA helix art, I decided to make some with ChatGPT - and it twisted the wrong direction...
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Congrats to Edward Gao on the publication of his paper - an improved synthesis of damaged pyrimidines - doi: 10.1080/15257770.2024.2437038
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image credit: ScienceAlert see us on Bluesky @koolchemistry.bsky.social
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credit: Neuroscience News follow us on bluesky: @koolchemistry.bsky.social
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