Forty sites of TRP channel regulation! A review of binding sites on TRP channels discovered by now. @IrinaTalyzina @knadezhdinPhD https://t.co/1OiARkqDoZ

Happy to share our new review of TRP channel structural pharmacology that describes 40 sites of TRP channel regulation discovered by now! @IrinaTalyzina @knadezhdinPhD https://t.co/1OiARkqDoZ

My first paper in @Schwalbe_BMRZ, to which I really contributed substantially is now online. A story about the FGFR receptor and it's inhibition by a small molecule in cells and in solution. [Spoiler] membrane matters! https://t.co/qoJLHsr64H

To Get Images of This Fast-Acting Brain Protein, Scientists Had to Slow It Down @shantigangwar @MariaKarela3 @knadezhdinPhD @LauraYen42 @MKCMU

Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels @knadezhdinPhD @arthurCantab https://t.co/iybiBlmqJ3

Happy to share: Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels. Fantastic collaboration with the group of Roman Efremov! @knadezhdinPhD @arthurCantab

Gain of function mutations in the TRPV4 #ionchannel cause a variety of musculoskeletal and neurological diseases, but the mechanism is unclear. A new paper shows the role of endothelial cells in blood-CNS barrier breakdown.

Indeed, to assemble our in-house device, we used many ideas published by @cryoET (C-SPAM) in https://t.co/T6413mOif2 and by @RubinsteinJohn (Shake-it-off) in

We solved several different states of the GluK2 (kainate) receptor using cryo-EM, including the open conformation 👇 https://t.co/BxPz57Nvgp

Happy to share our results on how the plant lectin Concanavalin A helped to open the channel of kainate receptor for the first time! @shantigangwar @MariaKarela3 @knadezhdinPhD @LauraYen42 @MKCMU https://t.co/NEyXvk9sgu

Happy to share the first structure of kainate receptor channel in the open state. The channel was opened by agonist glutamate and positive allosteric modulators plant lectin Concanavalin A (ConA) and BPAM344. @shantigangwar @MariaKarela3 @knadezhdinPhD https://t.co/NEyXvk9sgu

Huang, Y., Kumar, S., Lee, J. et al. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution | Nat Struct Mol Biol https://t.co/U8KGFsjdvD

Physiological temperature drives TRPM4 ligand recognition and gating. Congrats to the team!

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! @knadezhdinPhD @arthurCantab @IrinaTalyzina https://t.co/rWltNPZUbZ

First structures that illustrate opening of wild-type human TRPV3 (no sensitizing mutations!) by agonists, 2-APB or THCV, acting through different binding sites and expelling lipid from the vanilloid site. @knadezhdinPhD @arthurCantab @IrinaTalyzina https://t.co/rWltNPZUbZ

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! @knadezhdinPhD @arthurCantab @IrinaTalyzina https://t.co/rWltNPZUbZ

Another great work by Vera Moiseenkova-Bell and Andreas Leffler groups - much needed data on TRPV2 acid sensitive. Functional and structural insights into activation of TRPV2 by weak acids | The EMBO Journal

Happy to share our new paper on the structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Collaboration between V. Chubanov, A. Sobolevsky @AlexanderSobol6 and M. Kurnikova @MKCMU labs. @knadezhdinPhD @arthurCantab https://t.co/HQUvfl2ZsY

I'm happy to announce that v5 of🔬Follow Relion Gracefully is now live! This version provides a comprehensive dashboard for seamless interaction with your #cryoem data in Relion. Check it out: https://t.co/9qQklvq5Rw

Happy to share our new review on molecular pharmacology of calcium-selective TRP channel TRPV6. @arthurCantab https://t.co/QvW8QjiUdE