Julie Yoo
@julesyoo
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GP @a16z investing in healthcare; co-founder @kyruus ; alum of endeca, HST, MIT, SFS.
SF Bay Area
Joined December 2008
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Pinned Tweet
What are some of the Grand Challenges in Healthcare that AI gives us a shot at addressing? Come along with
@vijaypande
and I as we jam on:
➡️The claim as a bundle of logic to be automated.
➡️Always-on clinical trial A/B tests at population scale.
➡️Spot pricing for healthcare…
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1/ Company building in healthcare is different than with other tech startups due to many factors, including complex incentives, information asymmetry, and regulatory dynamics.
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1/ We’re living thru The Great Unlock in healthcare - things we thought would take 10+ yrs to play out are now playing out in 2-3. Massive dislocation is changing the very topology of the industry, enabling tech to be wedged into zones that were historically intractable.
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1/ Digital health is now growing quickly enough to support the need for a new dedicated tech stack. These companies require similar infra to trad’l providers but the relevant existing HCIT systems make you want to say “the 1990’s called and they want their software back.”
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1/ We’re entering a new golden era for tech-enabled healthcare. The intersection of care delivery, enterprise tech & consumer-grade experience is giving rise to the care models, infra platforms & payment engines that will define the next iteration of our healthcare system.
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1/ Digital health companies are at the tip of the spear of VBC, as they’re often implementing novel care models with actions not covered by standard billing codes, and don't have the burden of ossified infra/behavioral norms from decades of FFS as the main way of doing business.
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1/An entire multi-$1B care navigation industry exists because it's so hard to decode which doctors are in network, what services are covered, and how much they cost. What if we went upstream to address a key root of the problem- the underlying payor-provider contracts themselves?
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New year, new fund, new name to recognize the scale of opportunity in Bio+Health. A bit on the glow-in-the-dark founders we backed in '21, and what we're excited about in '22 with our new $1.5B/$5B early-stage/growth vehicles:
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The
@a16z
Healthcare Portfolio is hiring!! As someone with a last name that starts w/ 'Y', I will go in reverse alpha order by company name:
@ZusHealthHQ
: infra platform (patient 360, PRM) for digital health builders
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24
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We’re discussing “The new tech stack for virtual-first healthcare” w
@pmarca
,
@vijaypande
@vintweeta
@JorgeCondeBio
+ builders
@cwhogg
@fyietc
@folxhealth
@anmaslak
@sidviswanathan
. Today, Jan 13 at 6:00 PM PST on
@joinclubhouse
. Join us!
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The surface area of healthcare is massive; even a tiny niche could be a billion dollars deep! This video aims to break it down w/ a framework describing the zones of opportunity for tech-enabled care delivery startups:
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Are you a healthcare biz model nerd? Get a kick out of Health Affairs articles and digital health 10-Ks? Psyched about the future of virtual-first value-based care? Come be a Healthcare Deal Analyst on Team
@a16z
bio+health
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1/ Digital health internet browser, Build-a-Bear for EHR, Lego blocks for healthcare builders. Whatever the analogy,
@ZusHealthHQ
seeks to let the builders build with a new digital health developer platform and community, and
@Jonathan_Bush
at the helm.
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0/ I'm excited to have led the Seed + Series A and to be joining the board of
@AlphaHealthAI
, to reduce the cost of healthcare, and help providers be “better stewards of the healthcare dollar.”
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The entirety of healthcare administration needs to be "Turbo Tax'ed" - to make it simpler to navigate, more transparent, and less prone to high-stake errors. If you're gonna do it, might as well start with the nation's biggest single source of health coverage - Medicaid - and put…
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Excited to announce our investment in
@CareByFirefly
, which has rebuilt the modern health benefits stack to deliver "half-priced healthcare that's twice as good". Psyched to partner w/
@fyietc
@jeffgreenberg4
@Andy_Ellner
-
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Falls are leading cause of injury death amongst seniors (30M falls, 3M ER visits, $50B/yr). Thrilled to back
@amichellerees
+
@hari_arul
and
@age_bold
, which uses engaging fitness programs & clinical rigor to help seniors live strong, happy, healthy lives 💪
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1/ Healthtech builders and fintech builders are kindred spirits - we both deal with regulatory hairballs, complex distribution pathways, and ossified data and transactional standards that are difficult to change. But mash 'em up, and great things ensue.
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1/ thrilled to be investing in
@BayesianHealth
as it brings to market its clinical intelligence infrastructure platform that inserts validated AI into care delivery workflows, and creates leverage across our currently constrained physician supply.
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.
@dhaber
and I are on the lookout for great fintech plays in a number of areas of healthcare, 3 of which we outlined in this month’s
@a16z
fintech newsletter
.
@julesyoo
and I are very excited about the intersection of Fintech x Healthcare: "As fintech makes its way into healthcare services and software, we see the potential to rewire incentives and remove inefficiencies to pave the way for a more value-oriented healthcare system."
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Tmrw on CH,
@a16z
hosts the healthcare-meets-comedy author who inspired a whole generation of toddlers to disrupt the legacy clinical research regime:
@nikillinit
.
@JorgeCondeBio
,
@pmarca
,
@vijaypande
,
@vintweeta
,
@nikillinit
, Feb 8 5PM PST
@joinclubhouse
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The one and only 🐐:
@Aly_Raisman
. She shares her thoughts on:
🤸♀️the transition from a highly regimented, tightly coached life of daily cutthroat competition, to one of more autonomy about the best use of her time...
🤸♀️...which now includes investing in companies impacting mental…
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1/ We all know the old trope about price shopping in healthcare - it’s nearly impossible to do because of lack of good pricing data and tools, and even when pricing data and tools exist, consumers rarely actually shop.
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0/ ~20% of annual US deaths are attributable to dietary risks. Most metabolic health programs solving diet-related chronic disease offer content and behavioral coaching, but leave out the part about actually obtaining IRL food, tailored to medical needs and personal preferences.
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@chrissyfarr
I find all of these things very sexy… we call it ‘the plight of the 3-letter acronyms’ aka how to disrupt PBM, CRO, GPO, TPA, RCM… and UHG :)
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Your home will eventually be a primary site of care. To get there we need to rebuild the fragmented home health value chain (supplies & logistics, auth / reimbursement, patient / provider experience) into a single, unified platform to serve end-to-end home health needs.
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I laugh-cried reading this report again: “35 digital health companies received over $2M in funding in 2011” 😂😢
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“We have Star Wars medicine, Flinstones healthcare system.” Timely statement from Dr Freda Lewis-Hall, who reminds us to uphold the simple guiding principle of patient centricity in all we build, whether in clinical research or care delivery.
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1/ After leading their seed round, we're proud to continue partnering with
@vjkedar
and his team at
@TomorrowHealth1
by leading their Series A, as they expand their 'reimbursed commerce' platform to patients in need of better home health / DME services.
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Active week for
@a16z
healthcare portfolio!
1/ Congrats to
@jdesai01
and the whole
@PatientPing
team for a great milestone along their path to building the definitive operating system for care transitions!
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1/ Healthcare x fintech’s biggest prize: "the financial OS for providers". Despite $100B's being poured into claims processing every year (RCM) to help providers get paid, there's still no clear system of record for tracking/reconciling/predicting providers' financial flows.
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1/ Much of the commentary on healthtech centers on the debate between software vs tech-enabled services. But it's not about which form factor is "better"... it's about which companies exhibit what we call biz model "magic", in its 3 main forms: LTV, Operating Leverage, and CAC:
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“If you make decisions that everyone likes all the time, then those are the decisions they would have made without you... by definition, the most important decisions are the ones that people don’t like and cause people to not like you.”
@bhorowitz
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2/
@ribbonhealthAPI
,
@Wheel_Health
,
@truepill_rx
,
@trymedallion
,
@aptible
,
@eligibleapi
,
@CerebraeInc
...these co's represent core operational infra that used to take hoards of manual labor, regulatory attorneys, & custom code to implement, but are now available via turnkey APIs.
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7
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B2C2B (bottom-up sales) spotted in the digital health wild 👀. Hear GTM gems on acquisition/pricing/product & more from:
@cwhogg
(
@MyMarleyMedical
)
@_KateRyder
(
@mavenclinic
)
@portwi01
(
@ButterflyNetInc
)
@sajithw
(
@benchling
)
@amichellerees
(
@age_bold
)
@Andrew_Le_MD
(
@buoyhealth
)
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21
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fun to jam w/healthcare PM crew on 'build vs buy for digital health tech stack'; so many things i wanted to buy (not build) 10 yrs ago for my own startup, but didn't exist, now exist! cheers to those building API-1st infra to help DH founders accelerate their time-to-market 🥂
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To my doctor cousin who bears the brunt of our extended family's self diagnosis and referral requests: hope is around the corner for us to torture you no more.
May a healthcare LLM plus marketplace replace the "internet and friends" protocol for engaging with the healthcare…
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There are cat ladies, shoe ladies...I'm a provider data lady.
@anmaslak
&
@NateTheFox
have created a fundamental building block for 10B's of healthcare transactions that need high-quality provider info. Excited to be partnering with
@ribbonhealthAPI
:
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Hear the origin stories of
@carebyginger
,
@PropellerHealth
,
@omadahealth
with Digital Health OG Founders
@kvsingh
,
@cwhogg
,
@seanduffy
on
@a16z
bio Clubhouse tmrw Apr 19 5pm PT -
5
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1/ Another crazy supply-demand mismatch problem, this one at intersection of edtech + healthtech: 20% of students have learning disabilities but only 1/5 get early dx needed to keep up w/ peers. Eval wait times = 2+ yrs (clinician shortage + manual processes); test cost = $10K+.
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Got creamed by a deaf/blind dude (mad respect), and a barefoot runner (why). But beat the guy in the full body Spiderman suit. Winning.
#SFHalfMarathon
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Le Tote buys Lord & Taylor... next up, digital health company buys struggling hospital chain.
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"If you took the patients of all the digital health players at HLTH and fiercely rounded up while squinting, you’d still only get to maybe 2% of the patients affected by the attendees of HIMSS."
Here's to the beginning 🛣️, and so much more left to build 🏗️.
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1/ Our 5th and final Digital Health GTM Playbook: Selling Through Channel Partners 🤝 🤝 🤝.
We spoke w/
@seanduffy
,
@flottobrasil
, and
@kvsingh
, and surveyed 36 other founders to get the inside scoop on how channel partnerships can work (and not work!).
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3/ I and my partners share some lessons for how to think about this in our latest podcast: .
Some highlights from the episode:
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"without great advances in technology, life on Earth certainly will not get better and may well get worse."
stay tuned for more from the bio + health team...
1/ A physician-scientist recently told me he was starting a company “to complete ‘the impact arc’—going from bench to bedside…to worldwide.”
We’re thrilled to announce
@a16z
’s Bio Fund 4: $1.5B to back founders building the future of bio + health.
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Time to reboot - a piece on unbundling primary care & the need for new infra to deliver on the promise of a connected care delivery system that is patient-centric, w holistic data to personalize care & automate the rote tasks that hold providers back from doing their best work.
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Barnes and Noble store opening in the location of the old Amazon 4-Star store.
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primary + specialty care as next wave of virtual clinics.
, it's really a thing.
life w/out employer-sponsored insurance - what could have been...
DM me if ur building a "cloud kitchen for hospitals"!
thx for gracing us w/ ur thoughts
@nikillinit
I will be creating pandemonium on clubhouse tonight and you are welcome to join me
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0/ Patina (noun): a gloss or sheen on a surface resulting from age or polishing. Love the meaning behind the name of
@jstoddard1
's newco
@patinahealth
, building a new primary care model that respects older adults’ preferences for aging in place w/dignity.
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0/ Every healthcare company will be a home health company. Excited to be backing
@zerogee
and
@BeharCameron
at
@SprinterHealth
as they build the infrastructure platform to enable just that.
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17
57
Miracle drugs (cell/gene txs, GLP1s) could break our healthcare system as designed today. What needs to be true about how insurance and care delivery work for these amazing products to be adopted in a durable way?
My Big Idea in 2024:
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Moderating an incredible group of builders on Friday to chat about digital health's "great unlock" moment. DM me with questions to pose to the panelists from
@capsulecares
@ro
@onemedical
@Amwell
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1/ “Solving consumer engagement is worth $1T to our org,” a health plan exec once said to me. While sensationalist, it’s a common trope that much of healthcare's problems stem from the system's inability to engage patients cost-effectively and at scale.
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0/ "The biggest company in the world will be a consumer health company!"
@vijaypande
+
@daisydwolf
shouted from the mountaintops last month. Now we unpack the core competencies these newcos need to nail to achieve that ambitious goal:
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11
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1/
@vijaypande
,
@OmnivorousRead
and I recorded a virtual
@a16z
podcast about virtual care: . This unfortunate pandemic is propelling adoption of virtual care capabilities, which have technically been around for a while but in early days of adoption.
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21
53
a chat w/
@mariots
of
@OscarHealth
about what it would take to build an AI-native health plan:
[4:55] Oscar origin story
[7:50] how going full stack allows you to control more of your destiny and maximize value capture
[8:48] the original build of the Oscar chassis
[12:18] real…
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5/ DM me if you’re building a product that resides in The New Tech Stack for Virtual-First Care:
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CMO/CPO Relations in Digital Health: when you ask digital health founders about 'the hard things about hard things', one of the most common topics that comes up is, "we need to figure out how to make our product teams and clinical teams work better together."
We hear it all the…
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Congrats to the
@a16z
bio+health peeps in 2021
@Rock_Health
Top 50:
@SavageLucia
(
@OmadaHealth
), Varun Ganapathi (
@AKASAHealth
),
@SuchiSaria
(
@BayesianHealth
),
@ImanAbuzeid
(
@JoinIncredible
) -
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11
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7/ Communicate a strong vision! But check your hubris and unverifiable claims at the door. If any industry can sniff out - and immediately reject - b.s., it’s healthcare. Stakes are higher when you’re dealing with patients’ lives.
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9
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I'll be chatting with
@suchisaria
of
@bayesianhealth
,
@sethHain
of Epic, and
@peteratmsr
of
@Microsoft
about "AI in Healthcare: The Opportunity Ahead" - Monday 5:15 pm, in the Colonial Room at
#JPM2024
.
We'll cover the state of the state, regulatory landscape, and predictions…
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8
47
Gettin' the band back together -
@vintweeta
turbocharged my team once before, can't wait to have her do it again!
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Healthcare x Fintech Opportunity Part II, feat.
@crsevern
of
@TurquoiseHC
@flottobrasil
of
@CedarNY
@andrewlangadams
of
@try_headway
@jimmychen
of
@JoinProviders
@fyietc
of
@CareByFirefly
Jade Chan of
@JuniperPlatform
w
@stephsmithio
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11
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1/
@smc90
@justin_larkinMD
Our take on new CMS price transparency rule for payors: addresses some gaps left open in last yr's hospital rule, such as handling non-employed physicians and MLR impact to payors for resulting shifts in spend.
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8
47
Let’s go Nate^2! Thrilled to put more fuel in the tank that powers better healthcare decisions for everyone
@ribbonhealthAPI
@anmaslak
@NateTheFox
We raised a $43.5M Series B led by
@generalcatalyst
along with
@a16z
@boxgroup
@Rock_Health
@sacjai
to become the leading API data platform in healthcare. Join us to make every care decision convenient, cost-effective, and high-quality.
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Amongst my favorite hobbies - debating the future of digital health... with an awesome group to boot. Next Tues 5pm PT on
@joinClubhouse
w
@AlyssaJoyJaffee
@vintweeta
@chrissyfarr
@azenooz
@deacon_christin
While the future of
#digitalhealth
is bright, it is going to be quite complex with many paths to take. Join
@chrissyfarr
,
@julesyoo
,
@vintweeta
,
@azenooz
,
@deacon_christin
, and me on Tuesday, March 30th at 7pm CT/5pm PT as we debate what's to come!
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1/ Healthtech CTOs who read Medicare manuals & build broker portals from scratch - unite!
@a16z
Advisory Partner Margaret McKenna built software in banking, consumer, academia, and gov't before gracing us with her presence in healthcare (most recently as CTO of
@DevotedHealth
).
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2/ Some things we’re excited about in bio and healthcare going into 2021:
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2/ Value chains are being rewired, the center of gravity of data is shifting. Regulation, typically thought of as a barrier to innovation, is actually serving as a catalyst for category creation (e.g. virtual care, price transparency, interoperability).
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Digital Health GTM Playbook
#6
- Bringing AI Products to Market in Enterprise Healthcare.
Part A - a JTBD framework for identifying valid use cases, overlaid with viability assessment of insertion point and business model:
Coming soon: Part B, in which…
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6
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2023 - we look fwd to: precision delivery of meds, chemical-induced proximity, the modern bio tech stack, the biggest company in the world!, and the value-based care stack
@beckypferdehirt
@BenPortney
@daisydwolf
@JayRughani
@JorgeCondeBio
@justin_larkinMD
@vijaypande
@vintweeta
With 2023 on the horizon, a16z asked our partners: What ONE big idea do you expect tech to tackle in the coming year?
From small modular reactors to having fun with AI applications, their answers tell us a lot about what's likely to come in tech. 👇
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Why Milu Matters:
▪️ Upwards of 80% of medical bills have an error
▪️ 1 in 3 prescriptions could be less expensive
▪️ 20M referrals are sent to the wrong type of specialist every year
Milu Health uses AI and interoperability rails to help consumers make sense of their doctor and…
1
5
42
소프트웨어가 세상을 먹는다.
Awesome to meet so many great entrepreneurs and investors in the motherland. Thx Hillspring for hosting us!
(And when in Rome… gen AI yourself as a k-pop star, h/t
@jkhamehl
)
Thanks to our good friends at for hosting a great event yesterday for entrepreneurs and investors in Seoul. My partners
@julesyoo
and
@kirbyman01
assure me that I didn't say anything too stupid in this story from
@kedglobal
(as I do not speak Korean) -…
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Thoroughly enjoyed debating these 4 big ideas: moneyball for healthcare, clean usable datasets (on humans not mice!), body batteries, engendering trust in the hc system. I’ve tried to build
#1
, investing in
#2
, waiting for
#3
,
#4
is hardest but so many co’s that give me optimism.
We're ready to hear Four Ideas That Could Change Health Care
With Daphne Koller, Ph.D., Robert Wachter, M.D., Vindell Washington, M.D., Julie Yoo, and STAT's
@ravindranize
@DaphneKoller
@Bob_Wachter
@julesyoo
@VindellW
#STATHealthTech
#healthcare
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1 reason healthcare is so hard: building a great care delivery biz requires competency in all the things-consumer+enterprise+fintech+clinical. Hence our multidiscipl approach to eval’ing & supporting companies. Thx
@pranavrajpurkar
@ARSaporta
for hosting!
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0/ Among the many mighty healthcare supply-demand mismatch problems, one of the most vexing is the low % of physicians participating in clinical trials, while most trials enroll insufficient patients, let alone a diverse enough set of patients representative of the population.
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1. Tech will automate & decentralize commodity aspects of pharmacy supply chain, so that higher level resources and sites of care can focus on complex therapy logistics; 2. Value is in killer apps that leverage data, not just data for data’s sake
@smc90
@julesyoo
@illscience
@benedictevans
@vijaypande
@martin_casado
@JorgeCondeBio
@cdixon
@andy23tran
@skupor
@astrange
@conniechan
@DCoolican
@CSGO
episode
#14
of 16 Minutes -- w
@julesyoo
@vmocherla
joel + host
@smc90
on:
* UPS drones delivering prescriptions to homes
* Apple opening electronic health records to veterans, but wherefore are we with EHRs?!
* hacking voice devices thru light commands
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Fundraising right now feels a lot like it did when I raised my series A-C in 2011-15 ('twas called HCIT back then); these 16 commandments capture the essence of the mindset that helped us take a clear-eyed approach to fundraising then, that apply still today:
Startups are facing a radically new market environment. To successfully execute a fundraise, founders will require a different mindset, approach, preparation, and process.
@manascripts
,
@jaytoj
,
@melissawasser
and Peter Blackwood offer their advice:
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We’ll be talking “Care After COVID” - this once-in-a-century opportunity to reinvent healthcare. w/
@Accolade
CMO and author of said book,
@DrNundy
. Hosted by me and
@JorgeCondeBio
,
@vijaypande
,
@pmarca
,
@vintweeta
Mon May 3, 5pm PT
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4/ Stack your customer-facing front line w/industry insiders who understand & appreciate the culture of your buyers & users. On eng side, hire for knowledge of latest and greatest tech, but w/the grit to deal with ossified legacy systems you’ll inevitably have to integrate with.
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1/ “Financial toxicity is a medical complication.” Hospitals suing patients and garnishing wages for unpaid bills (especially egregious when prices aren’t even disclosed upfront) can be just as damaging to a patient as a medical error.
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Design is now as essential as code, and it's a multiplayer game. Excited to be partnering with
@figmadesign
- esp at a time when healthcare access, payments, and care delivery experiences are in dire need of being redesigned from the ground up.
"That was the decade of code. Now, we are moving into the decade of design: One where design, not just code, is at the center of product development and successful organizations."
Peter Levine on our investing in
@Figmadesign
and team:
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2/ Healthcare startups can have breakthroughs if they set clear strategies to tie together product & services, create the right team makeup, and execute a thoughtful go-to-market <- the last one is where most stumbles tend to occur.
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@chrissyfarr
Solid off-the-shelf options for virtual 1st value-based EHR w/APIs only now just emerging. Would guess these new infra co’s will serve as EHR-type utility behind majority going 4ward; but will always be handful who build proprietary EHR w/ platformization in mind down the road.
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The new interoperability rules impose aggressive timelines on providers, payors, and healthtech during a frenzied time; but they’re a huge tailwind that will propel our industry higher up the stack of use cases to enable connected and efficient care.
episode
#26
of 16 Minutes news covers w
@julesyoo
@vmocherla
@smc90
new US govt health data rules:
*how do they fit into healthcare system, esp w everything else going on rn in hospitals?
*implications for patients, providers, payers, startups, incumbents?
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Ready, Games Fund One.
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What’s more exciting - that we can print vaccines, or that we’re only in the first inning of the engineered biological product development game... the future is bright.
1/ Another big day for COVID-19 vaccines! FDA panel votes to recommend emergency use authorization for Moderna’s mRNA vaccine.
@Moderna_tx
CEO
@Sbancel
shares HOW they made a vaccine *in less than a year* w/ me +
@omnivorousread
on
@a16z
Bio Eats World
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