So big-ish news, I am happy to announce that I've submitted the first paper of my PhD!!! And now get the chance to write my first twitter tutorial. (Thread + Preprint link below)

For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?

Lastly, I’d just like to thank my mentors and friends who have helped in this process. This includes the mentors above, but especially Casey (@casey6r0wn ) who isn’t with us anymore, but was essential in me to pursuing a PhD. So thanks and hope you enjoy this work!

In total, we reaffirm the germline genetics role on prostate cancer risk, find that neighborhood deprivation may influence prostate cancer etiology, and conclude these two variables largely act independently in their associations with PCa. https://t.co/iQpPYmNyCL

We then investigate potential GxE interactions between neighborhood deprivation and a validated prostate cancer PRS. We found that these two largely act independently on prostate cancer risk.

To investigate the association between neighborhood deprivation and PCa, we used a series of logistic regression models finding that series domains of deprivation were inversely associated with PCa risk.

We did this analysis in UK Biobank because of the available genotyping data, clinical information, and access to the English Indices of Deprivation, a series of metrics that calculate relative neighborhood deprivation in geographic areas across England.

In our new preprint, with @spence_jeffrey_ , @jkpritch , @Linda_Kachuri , and @johnwitte , we investigated the role of neighborhood socioeconomic status - and its potential GxE interaction with germline genetics - on PCa etiology https://t.co/iQpPYmN0Nd

To start off, prostate cancer (PCa) is the most common non-skin cancer in men and a ton of research has gone into understanding the etiology of this disease

HLA is the locus that everyone loves to hate, so it rarely gets invited to the GWAS party... There’s good reason for this. The region has extensive LD, high gene density and high polymorphism. (Thread + preprint link below ⬇️) (1/8)

We are recruiting postdoctoral fellows! Interested in using quantitative tools to study gene regulation in stem cell-derived developmental models? See below for more info and reach out

How is your genome build choice influencing your RNA-seq results? We saw ~4% of all genes, and ~39% of all quantified genes from six biospecimen types were impacted in one of three ways

So excited to share our work describing our experience creating & teaching a class on genetics,ethics, & society! tl;dr- bioethics education on relationship between science/scientists/society is impactful, something students want, and important for structural change in our field

@raungar and I are thrilled to share our paper on the trainee-led course on genetics, ethics, and society that was developed at Stanford: https://t.co/y7LiY5Bv6x (1/9)

BREAKING: The family of Henrietta Lacks is settling a lawsuit against a biotechnology company they accused of taking her cervical cells without her knowledge. They accused the company's leaders of reaping billions of dollars from a racist medical system.

If you are a member of ASHG, consider voting for me. I know a few things and I think there's some good I could do in this position. Alright, back to avoiding twitter for a few months

2nd tweet of the day (very exciting)! As some of you know, I'm running for the Trainee Director position on the @GeneticsSociety (ASHG) Board of Directors. I'm passionate about service, advocacy, and education, and this is my way to continue serving the Human Genetics community.

Hi all! Earlier this year, I had the honor of interning at the @WHOSTP, specifically within #PCAST. It was amazing working with brilliant people both within the office and the council. Now I'm back working on my PhD, and looking forward to what policy holds for me in the future.

We won. ❤️✊

Today, the President’s Council of Advisors on Science and Technology (PCAST) released recommendations to help support and grow the U.S. public health workforce. Learn more here: