Johnson Cilia Lab
@johnsoncilialab
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Joined February 2017
This work from our lab analysing the 100k ciliopathy cohort revealed opportunities for improved diagnosis rates, requiring better phenotyping data to facilitate accurate variant interpretation. Analysis of structural and splice variants improved diagnostic yield.
Delighted to see our commentary article in AJMG discussing lessons learned from analysis of the 100,000 Genomes Project ciliopathy cohort @GabrielleWheway @MrGenePoole @johnsoncilialab @ChrisM_Watson @GenomicsEngland
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Congratulations @SunaynaBest @Kat_Szymanska from the lab on having this fantastic work published!
@JMG_BMJ @j_ellingford @jamesapoulter @rbvrs @MrGenePoole @GabrielleWheway @GenomicsEngland Great to work with @GabrielleWheway @jamesapoulter @Kat_Szymanska @j_ellingford @rbvrs @GenomicsEngland @johnsoncilialab @MrGenePoole and others to identify this interesting range of diagnoses for suspected #ciliopathy patients recruited to #100k.
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Just out! This fantastic paper uses topological data analysis to study genotype-phenotype correlations in Primary Ciliary Dyskinesia. Our own @SunaynaBest was involved in this work! #PCD #cilia
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This review about the mechanisms by which actin controls ciliogenesis is out today! Congratulations Claire and Alice! #cilia #actin #universityleeds
https://t.co/313m6FrcAX
frontiersin.org
Primary cilia are microtubule-based organelles that extend from the apical surface of most mammalian cells, forming when the basal body (derived from the mot...
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Alice’s paper now on biorxiv identifying ROCK2 as a therapeutic target for ciliopathies!
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Although we’re still working from home, we’re almost on the verge of getting back into the lab! 🎉Meanwhile we’re soaking in all the fantastic cilia science at the 8th #UKCilia2020 e-symposium! #ciliacommunity #thesciencegoeson
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We continue to meet online to discuss science (as well as our favourite walking locations) as we wait to go back into the lab! #workingfromhome #teammeckel #covidtime
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Our Stem Cell group members spent all of yesterday extracting bovine photoreceptor outer segments (POS) using the fantastic Parinot et. al. protocol! These will be used to assess phagocytosis in retinal pigmented epithelium we have derived from iPSCs carrying patient mutations.
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Our PhD student Rowan imaging her stem cells this afternoon #cilia #phdstudent #EyeResearchMatters #stemcells
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Great to see cilia feature in 2 of the top 4 images from the institute #Scienceasart competition. #cilia
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Two members of our lab group placed in the top 3 for this competition out of 72 entries! Looking forward to seeing the art work on the walls in WTBB. #Cilia #Scienceasart
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The next big cilia meeting will be in Sheffield, which is the @UKCiliaNetwork meeting on 22nd of March. Our next #CiliaClub meeting will be in Edinburgh, September 2019.
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To round off presentations for this #CiliaClub Andrew Jarman from Edinburgh introduced us to the auditory neuron cilia in #Drosophila.
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Xiaoming from the Malicki Lab in Sheffield is presenting her data looking at how Rod opsin is targetted to the photoreceptor cilium. Correct targeting of opsin is essential for sight. #Fightforsight @fightforsightUK #CiliaClub
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Interesting structure-function data of CCDC61 shown in Takeshi's presentation. #CiliaClub He's also currently recruiting PhD Students!#structuralbiology
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Welcome to the #cilia field Miguel and Laura! Looking forward to seeing the data that will be coming out of the Miles lab from Newcastle in the coming years. #CiliaClub
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Anne-Gaëlle Borycki gave a great talk on primary cilia in skeletal muscle cells and hedgehog signalling #CiliaClub
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Priyanka Anujan just presented her work in Zebrafish and Mice looking at the pathway involved in multiciliation of cells. #CiliaClub #Cilia
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Two great talks on clinical and genetic aspects of #PCD to kick start #CiliaClub. First talk from Dr. Evie Robson and second from Dr. Sunayna Best who presented their work with Dr. Hannah Mitchison from @GGM_ICH
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