MorrisLabUNC
@johnpmorrisiv
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Cancer biologists at the nexus of genetics, cell fate decisions, and evolution. We think about how cells become unique.
Lineberger Cancer Center, UNC
Joined September 2019
Since then the fits and starts these emergent fates take to acquire malignancy has been one of the big questions. In collaboration with @TimourBaslan @sparklingpm @LoweLabMSKCC and many others we’ve been able to visualize evolutionary routes to malignancy unleashed by losing p53
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Nearly 20 years ago I was introduced to the wild world of pancreas biology and how the mutations that cause it to transform break cells free from developmental and regenerative programs forged in the fire of evolution.
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The Morris Lab is up and running. We've put together a great team and are actively recruiting a postdoc interested in studying how malignant heterogeneity develops in hard to treat tumors. DM us if interested.
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Harnessing therapy triggered senescence to remodel the pancreatic cancer niche to capitalize on drug accessibility and unleash anti tumor immunity. https://t.co/LC447U7N7Y A great collaboration with @Marcus_Ruscetti and @r_mezzadra
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and (3) how access to normal differentiation is changed upon progression to malignancy.
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Then think deeply about (1) how oncogenes reprogram normal regenerative plasticity, (2) how this relates to the ability of perturbed pre-malignant lineages to access normal homeostatic "memory"...
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Read this great new paper https://t.co/vqaxYO85xW and then read this landmark study https://t.co/j9KXXKlYZC.
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