Miguel C. Santoscoy
@israsantoscoy
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Passionate about making a meaningful impact on patients lives using innovative science
Boston, MA
Joined September 2016
Proud to share that our study is now published, this is the first demonstration of Metabolic Engineering applied to Gene Therapy Development!. Check it out 👇 and reach out if interested!! 🙂. Thanks @Reallyviral for your support on this idea and my time at @MGH_RI @harvardmed.
This study was conceived and led by @israsantoscoy a former postdoctoral fellow in the lab. Miguel used his bioengineering experience to take a new innovative approach to improve our extracellular vesicle AAV (EV-AAV) system.
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Super excited to share our #preprint! One of my main postdoc projects 🚀, MC5 and AAV gene therapy vector targeting #microglia 🧠. This moves us forward in targeted gene delivery and brings hope for smarter gene therapies to tackle #neurodegeneration someday 🤞💡.
Please find our latest preprint here:.Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice | bioRxiv.
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Excited to share our latest work: We have pioneered the use of #MetabolicEngineering for streamlining the production of safe and potent gene therapies. Grateful with @Reallyviral for his support throughout my training at @MGH_RI and @harvardmed 🧬🥼💉🐁.
biorxiv.org
Adeno-associated viruses (AAV) are promising vectors for gene therapy due to their efficacy in vivo . However, there is room for improvement to address key limitations such as the pre-existing...
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RT @tomaspueyo: Here are the most FASCINATING facts I could find about Mexico:. 1. Mexico is so huge it’s hard to comprehend. You can fit 3….
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RT @Reallyviral: We are pleased to announce publication of our manuscript “In vivo selection in non-human primates identifies AAV capsids f….
cell.com
IT delivery of AAV vectors results in low on-target delivery to spinal cord and high-off target delivery to the periphery. Maguire and colleagues identify new capsids that mediate a favorable...
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RT @edwinaah: ‼️Great work by @Reallyviral and @israsantoscoy: Novel AAV Capsid and Truncated ChAT Promoter enhance the transduction of str….
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RT @MarkusDeserno: Hello, my absolutely lovely membrane peeps! Would you maybe, pretty-please, let me proudly steer you to a MINI-REVIEW I….
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RT @NatureBiotech: Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy https:/….
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RT @jlistgarten: It's been a long saga, but our ML for AAV library design work has finally been published!
science.org
Computational, data-driven redesign of a state-of-the-art AAV initial library improves downstream selection for therapeutic uses.
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RT @NatChemEng: The first issue of Nature Chemical Engineering is now live! 🎉. We're excited to finally begin highlighting the breadth of c….
nature.com
Recalcitrant C–C bonds in lignin limit the monomer yield of current depolymerization strategies that target labile C–O bonds. Now, Emiel Hensen...
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RT @NatureBiotech: Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology .
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RT @MGH_RI: Researchers from @MGHMedicine and colleagues find insight into causes of heart failure with preserved ejection fraction, in a @….
nature.com
Nature Communications - Systemic inflammation is recognized as a central pathobiologic feature in heart failure with preserved ejection fraction (HFpEF). Here, the authors report 70 pro- and...
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RT @MolTherapy: AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfecta #MTNA.
cell.com
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility. OI is commonly caused by single-nucleotide mutation(s) in the type I collagens (Col1a1 and Col1a2). Shim and...
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RT @mbelmbel99: Systems metabolic engineering for the production of pharmaceutical natural products.
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RT @zhangf: Thrilled to announce our latest exploration of CRISPR! By developing an advanced algorithm, we’ve analyzed 8 terabases of micro….
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RT @SuperSphingoJan: The beauty of membrane blebs during cell division. What a great phenomenon to study with @beesthoven thanks to @EMBO a….
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RT @CRISPRTX: The UK Medicines and Healthcare products Regulatory Agency approves the CRISPR/Cas9 gene-edited treatment for #SickleCellDise….
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Day 2 #AIChE2023 @ChEnected @aicheeddiv .How can metabolic engineering further improve gene therapy vectors? . -find out TODAY in Celebration 15, Faculty Candidate Session: Food, Pharmaceuticals, and Bioengineering I at 12:30pm (my talk is at ~2:18pm)
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Day 1 in #AIChE2023 - Orlando, ready to talk with great researchers @Chenected and @aicheeddiv ☀️ 🏝️ 🤓 🧬 . If interested about how a chemical engineer can contribute to improve gene therapies, I’ll present a poster TODAY at Meet the Faculty Candidates session from 1-3pm, #28.
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