Ikjot Singh
@ikjot_sohal
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Dedicated to the question of how cells communicate in normal and disease physiology. I love seeing things under microscope! 🔬
West Lafayette, IN
Joined December 2013
Purdue proudly honored researchers at the Seed for Success Acorn Awards for securing $1 million+ in external funding for a single proposal 🌟 Congratulations to all recipients! Read here: https://t.co/7Lxj3eMio6
#PurdueResearch #Purduebiology #purduescience
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Today at the annual Seed for Success Acorn Awards ceremony, @Research_Purdue honored the accomplishments & innovative ideas of #Purdue researchers, recognizing PIs & co-PIs who secured research awards of $1M or more for a single proposal in FY2024.
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What a day for RNA! 😃
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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My better half got recognized by the American Society of Plant Biologists for her recent work! Super proud of her! 😍😍 No wonder she is in-charge of all the plants in the house... https://t.co/RcFcQa9KeY
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Everyone needs to know this 🤯
It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!
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I am thrilled that our work on developing a targeted miRNA therapeutic for prostate cancer is now published. Excellent work by @AhmedMaAbdelaal, @sudarshan762, Shreyas, @KenanOzzzz, and others, and grateful for the incredible mentorship of @AndreaKasinski! https://t.co/tpXqKfy9RJ
Happy to highlight a recent study from the Kasinski lab and collaborators where we developed a ligand for delivery of our fully modified miRNA, miR-34a to prostate cancer. https://t.co/i8MVVOmAm9
@ikjot_sohal @AhmedMaAbdelaal @sudarshan762 @KenanOzzzz
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Hello all #PurduePostdocs! PPDA is hosting a webinar tomorrow on the topic "US Immigration and Visa for postdocs and graduate students" Date: May, 16th, 2024 Time: 2:00 PM - 3:30 PM (EST) Zoom Link: https://t.co/V480oOYZDj See you all there! #Immigration #PostdocLife
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A rapid, cost-effective in vitro method for assessing the stability of oligonucleotide duplexes, crucial for the development of oligonucleotide therapeutics targeting orphan diseases and cancer : https://t.co/VaVjL2gA2n
#research #biochemistry
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Thank you to @PUCancerInst for the recognition! Grateful for the mentorship of @AndreaKasinski and the community spirit of the Kasinski Lab!
Celebrate with us! 👏 Today marks a milestone for our cancer institute. At the inaugural PICR Awards Ceremony, we honored members, staff and trainees who have made exceptional contributions to the field of #CancerResearch. Join us in recognizing their outstanding work! #Cancer
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I like sweaters, especially if they are hand-knitted by my better half!
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Being 5yrs on the functional side of #microRNA biology, I can say that delivery, stability, and off-target effects are the biggest challenges in developing microRNAs as therapy. @AndreaKasinski lab's great work tackles the stability side. Great work.🫡 https://t.co/CFhuESDBeH
nature.com
Oncogene - A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy
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First-in-class targeted microRNA therapy slows cancer tumor growth https://t.co/EONQjAef5x
apple.news
A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division. As reported in Oncogene,...
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Happy to share the first paper from my PhD work highlighting a new RNA-based cancer therapy using the 1st fully modified miR-34a, linked to folate. Many thanks to my great mentor @AndreaKasinski and other contributing authors including @ikjot_sohal
nature.com
Oncogene - A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy
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This is also my first co-corresponding author publication as a postdoc in the Kasinski lab! I am super proud of the teamwork, and mentorship of @AndreaKasinski! Follow the authors to hear more about this and upcoming work. Thank you! ~6
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When targeted to tumors via folate ligand conjugation, FM-miR-34a caused sustained silencing of critical oncogenes, such as MET, CD44 and AXL, leading to tumor regression and complete cures in some mice. ~5
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Through global transcriptomics and specific phenotypic assays, we demonstrated that FM-miR-34a downregulated more miR-34a targets and caused more robust downregulation in comparison to partially-modified miR-34a, "PM-miR-34a". ~4
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We developed a first-in-class fully chemically modified microRNA-34a "FM-miR-34a" that, as a result of the chemical modifications, had outstanding stability and activity, which was orders of magnitude higher than partially- or un-modified miR-34a. ~3
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First, a big shout-out to the talented first author @AhmedMaAbdelaal, co-corresponding author and a great mentor @AndreaKasinski, and all the other authors (Shreyas, @sudarshan762, Harish, @NadiaAtallah1, and Dr. Low) who worked tirelessly to make this study truly outstanding! ~2
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I am thrilled to share our latest work in targeted cancer therapy, describing development of a microRNA with outstanding stability and activity, and its tumor targeting. This exceptional work deserves an X-editorial (it's a tweetorial!), so here it is: https://t.co/Bv2lcW3ZYf ~1
nature.com
Oncogene - A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy
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