This novel BA.2.86 lineage was first detected by our Microbial Genomics laboratory (part of the MoH consortium). Now it appears to have already been disseminated globally. Way to go, @Katya_zel88! .

3/3 #I-ACT #CAR-Ttherapy #InnovationInCancerTreatment #Innovation #Ichilov #CellandGenetherapy.Roni Gamzu, @Shimrititis , Jonathan Semo, @AGlobersonLevin, Yael Cohen, @IritProf, @eli_sprecher.

2/3 At Ichilov, we're committed to providing innovative therapies to cancer patients in the ongoing fight against cancer.

1/3 Exciting news! Our Institute for Advanced Cellular Therapies achieved a significant milestone by developing the first In-house CAR-T therapy for cancer treatment.

@Elad_md 7/7 Therefore, we suggest that among healthy population, higher ketone bodies are not protective of cardiovascular disease and mortality and may even constitute a risk factor (independent of other classical factors).

@Elad_md 6/7 Our final analysis included 6796 participants. Our study found that elevated endogenous ketone bodies in a healthy community-based population is associated with a higher rate of cardiovascular disease and mortality.

@Elad_md 5/7 We have analyzed the Multi-Ethnic Study of Atherosclerosis (MESA) database: MESA is an ongoing prospective study of 6814 subjects of four racial/ethnic groups (Non-Hispanic White, Black/African American, Hispanic, and Chinese American) living in the USA.

@Elad_md 4/7 we aimed to explore the long-term association between circulating ketone bodies and cardiovascular outcomes and mortality in an ethnically diverse population free from cardiovascular disease at baseline.

@Elad_md 3/7 Given the increasing interest in ketones as a potential “protector” from cardiometabolic pathologies,.

@Elad_md 2/7 This was an international collaboration with researchers from world-class American universities, including, inter alia, Wake Forest, Stanford, Johns Hopkins, Harvard, U of Texas, and U of Chicago.

1/7 We are pleased to introduce our new study, recently published in the European Heart Journal. @Elad_md

8/8 Amos Adler, Sandra Reuter, Hiren Ghosh, Yuval Geffen, Mark V. Assous, Amit Rechavi.#NDM, #mobile_elements, #WGS, #transmission, #clones.

7/8 Overall, the study highlights the importance of understanding the genomic composition and transmission dynamics of NDME in hospital settings, and suggests that current surveillance measures are probably insufficient for tracing transmission sources.

6/8 The study found that only a minority of cases (between 6.3% to 33.3%) could be linked to other cases by both molecular and epidemiological criteria, suggesting that NDME had not spread via clonal expansion.

5/8 Phylogenetic analysis based on core genome SNP distances identified potential transmission events between patients with overlapping hospitalization periods.

4/8 The clonal structure was found to be highly diverse, with nine different mobile genetic element (MGE) modules identified in blaNDM-1-harboring isolates.

3/8 The study included 212 NDME isolates from 203 patients, with K. pneumoniae, E. coli, and E. cloacae being the most common species. The majority of isolates harbored the blaNDM-1 gene, with blaNDM-5 and blaNDM-15 also present in smaller numbers.

2/8 In this study, the molecular features and transmission events of NDME were studies in three Israeli hospitals (the Tel-Aviv Sourasky, Rambam and Sha'are-Zedek Medical Centers).

1/8 We have performed the first multicenter study tracking the transmission of NDM-producing Enterobacterales (NDME), one of the most serious threats related to antimicrobial resistance.

7/7 Thus the predictive performance of distinct biomarkers for in-hospital mortality due to COVID-19 varies amongst different age groups. Dr. Eugene Feigin.Dr. Tal Levinson.Dr. Asaf Wasserman.Dr. Shani Shenhar-Tsarfaty.Prof. Shlomo Berliner.Dr. Tomer Ziv-Baran.