Explore tweets tagged as #Multicopy
@rand_longevity Thank you Rand! Cellular aging is co-regulated by telomeric DNA and ribosomal DNA. Telomeric DNA and ribosomal DNA (rDNA) both belong to multicopy tandem repeat DNA arrays, which are highly unstable and prone to copy loss due to frequent transcription and other factors. For
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First, telomeric DNA consists of multicopy tandem repeat arrays and fully possesses all the essential features of a lifespan countdown timer: (1) It can be replicated during cell division to ensure each daughter cell inherits a copy; (2) The shortened length of these arrays in
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@CharlesMBrenner @_Simon_K @TylerMooreUS All eukaryotes have telomeres and rDNA, both of which are multicopy tandem repeat sequences. Both telomeres and rDNA bind to the p53 protein. Therefore, telomeres and rDNA have universal applicability as countdown timers for cell replication and aging. For example, the copy
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@_Simon_K Specifically, I proposed around 2011 that multicopy repetitive DNA such as telomeres act as temporal drivers for the programmed gene expression during cellular senescence. The chromosomal genome can be regarded as a database, while multicopy repetitive DNA including telomeres
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Telomere consists of multicopy tandem repeat arrays and fully possesses all the essential features of a lifespan countdown timer / clock: (1) It can be replicated during cell division to ensure each daughter cell inherits a copy; (2) The shortened length of these arrays in
@MarcosArrut “My research focus starts from a clear premise: aging as a genetically programmed phenomenon, executed by the epigenome.” That the epigenome serves as the execution layer is largely non-controversial at this point. But what/where is the “clock” that initiates and regulates this?
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All eukaryotes have telomeres and rDNA, both of which are multicopy tandem repeat sequences. Both telomeres and rDNA bind to the p53 protein. Therefore, telomeres and rDNA have universal applicability as countdown timers for cell replication and aging. For example, the copy
@_Simon_K @biluhuang @TylerMooreUS multiple species analysis does not support aging as caused by telomere shortening or deficiencies in ribosomal DNA arrays
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2.4 Cellular aging is co-regulated by telomeric DNA and ribosomal DNA. Telomeric DNA and ribosomal DNA (rDNA) both belong to multicopy tandem repeat DNA arrays, which are highly unstable and prone to copy loss due to frequent transcription and other factors. For decades, it has
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The genetic puzzle of multicopy genes: challenges and troubleshooting https://t.co/sBwRFEf6aE ♻️
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The Genetic Puzzle of Multicopy Genes: Challenges and Troubleshooting https://t.co/rq5nLh7w5s
#bioRxiv
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A System to Explore the Adaptive Dynamics of Multicopy Plasmids: The Role of Copy Number and Mutation Rate in Evolutionary Outcomes https://t.co/4mpG1QGCGl
#biorxiv_evobio
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Jisca van Dam @JiscoDisco (from the group of Arthur Ram at @LeidenBiology): A CRISPR/Cas9-based multicopy integration system for increased glucoamylase production in Aspergillus niger #KNVMmycology
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@ucworkroom1 @Paulfra07911928 @julie4butte5 @MazeLove14 @PlanetarySeed Discovery and engineering of retrons for precise genome editing Retrons can produce multicopy single-stranded DNA in cells through self-primed reverse transcription. However, their potential for inserting genetic cargos in eukaryotes remains largely unexplored. Here we report
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¡Renueva tus monitores con Multicopy y ViewSonic! 🖥️ De 24 y 27 pulgadas, curvos y más a precios únicos y válidos hasta agotar existencias o hasta el 31 de agosto. ✅ Inicia a renovar hoy tu espacio de trabajo. Compra en línea https://t.co/tNERZxblaI o envíanos un mensaje. 🙌
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Horizontal transfer promotes allele segregation in multicopy plasmids https://t.co/013L6knDop
#biorxiv_evobio
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This work touches on many things. It shows within-cell evolution constrains which genes will spread on high-copy plasmids. It also gives a strong hint of the origins of highly-abundant “cryptic” plasmids, showing that multicopy plasmids have strong incentives to lose genes. 13/
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@takeichi_kobo もしかしたら https://t.co/Qx5k6zqz5I な感じで、コンビニ利用できるかもしれませんね
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@Jan_Haris_ 🔬 Brilliant concept! Retrons show promise but targeting mitochondria presents unique challenges. Retrons reverse transcribe RNA into multicopy single-stranded DNA (msDNA) that remains covalently linked to their template RNA, making excellent donor templates. Recent work
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Quartet-based Genome-scale Species Tree Inference using Multicopy Gene Family Trees https://t.co/VT3ItEZNVJ
#biorxiv_evobio
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