Schroeder Research Group
@group_schroeder
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Small Molecules etc.
BTI and Department of Chemistry and Chemical Biology, Cornell University
Joined July 2019
How bacteria subvert plant immunity - see the perspective at https://t.co/ThITliq4PI for this fantastic Science paper by the van der Hoorn lab:
science.org
To prevent their detection, bacteria inhibit plant enzymes with a small molecule
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Google: "New math," a term for modern math education, emphasizes conceptual understanding and problem-solving skills over rote memorization. Applied below.
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Congratulations to Dillon and Josh! Their JACS paper reporting new insights into bacterial isoprenoid biosynthesis using a masked DMAPP probe:
pubs.acs.org
Isoprenoids are essential metabolites whose biosynthesis originates from two five-carbon (C5) isomers, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Although these isomers...
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Bile acids as androgen receptor antagonists: amazing work by our Weill collaborators, CJ Guo and David Artis:
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Ascaroside-based start-up Ascribe featured at Forbes:
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Marian and Safak's metabolic flux paper at Nature: https://t.co/MGY0cjdfaY Highlights include establishing the primary use of amino acids and bacterial RNA (!) as a tricarboxylic acid cycle carbon source.
nature.com
Nature - A strategy is introduced that infers whole-animal metabolic flux wiring from transcriptional phenotypes in the nematode Caenorhabditis elegans and several features in its adult metabolism...
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Our start-up Ascribe Bio https://t.co/sSHHe3xw0i announces investment by ICIG Ventures:
agribusinessglobal.com
ICIG Ventures invests in Ascribe to prepare for launch of Phytalix, a small-molecule biofungicide with pending regulatory approvals in Brazil and the U.S.
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Congratulations to Tae, Arif, and Chris on publication of their Nature paper, reporting a new class of bile acids that regulate cholesterol metabolism:
nature.com
Nature - A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent...
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C. elegans as a model for how host-microbe interactions rewire conserved amino acid metabolism: Yong-Uk's paper from Marian Walhout's lab:
nature.com
Nature Metabolism - In a C. elegans model of defective leucine catabolism, Lee et al. analyse how the complex interplay between host and bacteria rewires metabolism to enable host survival.
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Bingsen's perspective on how metabolic state feeds back on protein function and physiology: "Mechanisms of metabolism-coupled protein modifications" at Nature Chemical Biology:
nature.com
Nature Chemical Biology - This Perspective highlights how metabolic states regulate diverse protein modifications that affect physiology. In addition, the roles of subcellular localization of...
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Next up: our PODCAST on how host-microbe interactions regulate fat metabolism in C. elegans: https://t.co/YGYk4jAzkv… discussing our recent paper in Nature Communications: https://t.co/JUU6WPOSsp
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Must listen of the week: The Ascaroside Signaling PODCAST! Everything you always wanted to know about ascaroside signaling, dauer, MOGLs, and modular assembly: https://t.co/Go9o5j2A7x More entertaining than "This American Life", but generated with NotebookLM!
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Holoclara announced their Series A! Founded by Andrea Choe, Paul Sternberg, and Frank Schroeder, https://t.co/xf1xc77pqC is a great success story, nicely summarized here:
businesswire.com
Financing led by BOLD Capital Partners, alongside early investments from Horizons Ventures and participation from syndicate of leading angel investors
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Cross-phylum detection of small-molecule signatures: Ping Hsueh's lab reports the identification of a fungal GPCR sensing nematode pheromones (ascarosides), see Nature Mircrobiology:
nature.com
Nature Microbiology - Nematode signals such as ascarosides are sensed by G protein-coupled receptors of a nematode-trapping fungus, resulting in fungal activation of cAMP–PKA signalling and...
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Microbiota regulate conserved lipid metabolism via nuclear receptor signaling: see Bennett's paper "Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans" just published at Nature Commun.: https://t.co/2s0Qfg6Cdy
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Protein function is coupled to distinct branches of fatty acid metabolism - see Bingsen's PNAS paper "Amino acid- and protein-specificity of protein fatty acylation in C. elegans" just published at https://t.co/7fJq8WZua4
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A nice summary and comments on our acylspermidine story ‘The buck stops with spermidine | Nature Chemical Biology’
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"The buck stops with spermidine" - excellent News&Views piece on our acylspermidine paper by Anthony Michael:
nature.com
Nature Chemical Biology - Sirtuins remove post-translationally added acyl groups from protein lysines. New work shows the surprising metabolic fate of acyl groups removed from mitochondrial...
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Microbiota-derived vitamin B12 reduces cholinergic signalling in the nervous system - see Wookyu's paper out at Nature Cell Biology today.
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