Thrilled to introduce Electrophorus! From universal e-chem systems, to ROS delivery and programmable O2 control — we design custom solutions for e-chem in the life sciences: grateful to @CEITEC_Brno @JIC_Brno for incubation support!

RT @CEITEC_Brno: From locusts to the human brain: @eglo_physchem revolutionizes neural engineering 🚀. “The facilities and laboratories, es….

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We are embarking on new directions of using electrochemical oxygen reduction reactions to tailor the local environment of excitable cells and create a novel form of neuromodulation using DC. If you are interested in exciting PhD or postdoc research, email me @CEITEC_Brno

RT @diegoghezzi: My lab has two open positions. We are looking for a PhD student in Neuroscience and a Postdoc in Electrical Engineering or….

RT @CEITEC_Brno: On October 31, 2024, over 100 CzechNanoLab users gathered at CEITEC @VUTvBrne. The event brought together researchers, tec….

if you are interested in using electrical hypoxia, ROS, pH gradients, and other redox reactions at neurostim electrodes to modulate physiology of excitable cells get in touch - we are interested in collaborations and recruiting new team members.

Honored that we received the prestigious EXPRO grant, to fuel our work @CEITEC_Brno for the next 5 years. "Orthogonal Neuromodulation" aims to augment electrical neurostimulation by exploiting redox reactions to alter local chemical environment and hack into cell signalling

my talk at the London Temporal Interference Workshop organized by @nir_grossman - this was an excellent event full of constructive debate that not only catalyzed scientific follow-up, but inspired how I think about better meeting organization. thanks!.

Many thanks to the organizers of the #Orbitaly conference for the invitation to present our work on the Faraday scalpel: how to use redox electrochemistry to regulate O2 and ROS in biology. Bologna is a lovely city with impressive 12th century conference venues!

Our ongoing work focuses on mapping these reactions as a function of AC frequency. Just how capacitive are high-frequency signals? The results are surprising and not straightforward :).

Oxygen reduction leads to a hypoxia zone around the electrode within seconds. Meanwhile, we were surprised by the prevalence of reactive chlorine species forming under anodic polarizations competing with oxygen evolution.

The key message is that using local microsensors is the way to go to definitively assign reaction onsets, and quantify products like peroxide, H2, chlorine, and pH or [O2]changes.

Then there is the potential onsets and currents of water splitting (outside water window) which vary a lot depending on electrolyte. PBS behaves very different from culture medium, where the window shifts, and the oxygen evolution reaction is impeded.

In complex media, there is really no potential at which no net faradaic current flows. Either organic substrates are oxidized, or oxygen is reduced. These reactions support 10-50 uA/cm2 of steady-state current density.

Right in the the middle of the water window, there is a strong contribution of oxygen reduction reactions, and in culture media, lots of anodic oxidation of organic substrates.

People usually consider the “water window” between the potentials at which water splitting occurs to be electrochemically inert and dominated by capacitive charge transfer. This is not really accurate in most cases.

Happy to share our opus: Shattering the Water Window: Comprehensive Mapping of Faradaic Reactions on Bioelectronics Electrodes | ACS Applied Materials & Interfaces about charge transfer reactions on electrodes used in neuroscience/biophysics @CEITEC_Brno

I am well-aware of fancy systems people are using for patterning/ablation with lithography-like resolution, but these are expensive. I am thinking in a lower price range, for resolution in the tens of microns range. suggestions? :D :D.

fellow scientists/engineers: we are looking for affordable laser cutting tools. We have a CO2 laser for cutting plastic parts, but we want some tools for ablation of metal thin films from plastic substrates, cutting thin metal parts, and also something for patterning parylene-c.

the model in 2020 predicts that certain AM frequencies will give lower threshold currents, which we confirm in some situations, but the effect is not strong. Curiously, B. Katz in 1939 described that threshold for kHz stimulation (frog sciatic) is not affected by AM frequency.