estebanL
@ealopera14
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Joined December 2017
Proud of @ealopera14 for the great defense and becoming Dr. Lopera 🎉 now you have wings to fly high on your future! Success!
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What a beautiful birthday present I received today: a thesis book by @ealopera14 on the value of population biobanks in studying complex diseases, with particular focus on @LifelinesNL. Congratulations, @ealopera14 @serenasanna1 @PatrickDeelen @wijmenga_cisca @GroMicrobiome
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5/5 We sincerely thank the biobanks @LifelinesNL and The Netherlands ACM/PLN registry, as well as all the collaborators who made this work possible. @serenasanna1, @PatrickDeelen, @Shuangli1330, @RemcodeBrouwer, @mswertz, @LudeFranke, @wijmenga_cisca, @UMCGgenetica.
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4/5 We also found that polygenic prediction of QRS duration is stronger in symptomatic carriers, even when the average polygenic score is similar between the two groups of carriers. Larger genetic datasets are needed to investigate this further.
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3/5 The shorter QRS duration was replicated in two independent cohorts, including The Netherlands ACM/PLN registry, proving a unique characteristic of asymptomatic carriers, with potential use for early diagnostic.
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2/5 We investigated potentially protective genetic and phenotypic factors by comparing asymptomatic carriers with general population. We found a shorter QRS duration, higher heart rate and lower heart rate variability in asymptomatic carriers.
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1/5 Why don’t all carriers of the rare PLN:p.Arg14del variant get cardiomyopathy? In our paper we explore the modifiers of this penetrance using the Lifelines general population biobank. https://t.co/yYaJOWJwU6
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❓Interested in genetic analysis of the #microbiome ? 📰Challenges and future directions for studying effects of host genetics on the gut microbiome 🧑🏿🤝🧑🏼@serenasanna1 @SashaZhernakova
@A_van_der_graaf @jingyuan_fu @AKurilshikov ⬇️⬇️ https://t.co/VjIt95V6dG
@NatureGenet
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Hi everyone, Today, our paper on microbiome host genetics (🧬) is published in Nature Genetics! 🎉🎉🎉 A 🧵 on what we found with @SashaZhernakova, @serenasanna1, @ealopera14, @AKurilshikov and @Shixian00000
https://t.co/6ks3jufdwl
nature.com
Nature Genetics - A genome-wide association study of 207 taxa and 205 pathways representing gut microbial composition and function from 7,738 individuals of the Dutch Microbiome Project identifies...
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Today we're sharing an analysis of the genetics behind two important COVID-19 genes: ACE2 and TMPRSS2. A thread on what we have found 1/9 https://t.co/qfqW6gByOf
@LifelinesNL @serenasanna1
medrxiv.org
Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of symptoms, from very mild or no symptomes, to flu-like symptoms, and in more severe cases, to pneumonia, acute...
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Looking at panel performance, in samples of African ancestry, imputation is significantly improved over existing panels. 4/
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Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity https://t.co/LFvkZvvF9z
#biorxiv_evobio
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This thread 🤗👇
friendly reminder in times of uncertainty and misinformation: anecdotes are not data. (good) data is carefully measured and collected information based on a range of subject-dependent factors, including, but not limited to, controlled variables, meta-analysis, and randomization
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Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemic https://t.co/ZqTyrXAQim
#biorxiv_evobio
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