@CA_AstroComm Hi! I'm Dr. Ashley Dalrymple. My PhD is in Neuroscience. I'm also an engineer. #WomenInSTEM #WSJRetractNow

This past week has been quite eventful for the NERVES Lab!⚡️🔥. Our BME undergraduate student, Chimdi, graduated!! 👩‍🎓. PhD student, Abby, proposed her thesis and became a PhD Candidate!! 🦾. I am a #proudPI 🫶

This will be my first #ASNR2025. I am excited to catch up with some of my favourite people, meet more clinical colleagues, and discuss the important research in neurorehab!. 1 more week!.

RT @NANS_ION: 🚀 Discover groundbreaking #SCS applications beyond pain management—respiratory control, sensory restoration, cardiovascular r….

@GrumpyReviewer2.

If you're racing to beat the early bird deadline for RehabWeek, don't forget to register for our workshop! It's going to be very stimulating⚡ (that pun never gets old!). Kilohertz Carrier Frequencies for Transcutaneous Spinal Cord Stimulation: What’s All The Buzz About?

Something that you may not realize is that Taylor came out with 4 albums from the time I started writing this paper 🫶. I could barely catch up with the song titles, and so many were perfect 😍.

If you'll be at ASNR in April, come join our session for a stimulating⚡discussion about transcutaneous spinal cord stimulation!.

Doug is The Man for approving my Wildest Dreams and ideas. Thank you from all of Us. This Is Me Trying to squeeze in a few more 😉.

Call it What You Want, but This is What You Came For. I Wish You Would read this Enchanted paper! Don’t Blame Me for incorporating >20 Easter eggs throughout The Manuscript. Maybe Only the Young will be able to find them all.

Reviewer 2: Question…? Tell Me Why do you have to be so Mean? You Need to Calm Down and not be the Anti-Hero. After incorporating your feedback, Everything Has Changed. But I am The Lucky One, because I think it’s a lot better now. Two reviewers Is Better Than One.

Big thanks to Kip Ludwig for his help identifying clinical and regulatory safety criteria and device recalls.

Dear Reader, while I am the Mastermind, I would like to thank my coauthors @dougweberlab Sonny Jones, @jbfal1 Rob Shepherd for their invaluable input in writing The Manuscript. This paper is Ours.

Long Story Short, implanted neural interfaces have successfully treated a variety of conditions. However, longevity is impeded by mechanical, technological, and biological barriers. Novel materials and techniques addressing these barriers promise to give people The Best Day.

The Other Side of the Door includes other logistics such as data storage and programming. With increased complexity and channel count, data security and storage need to be addressed. Further, control strategies for programming devices need to be developed to avoid a Glitch.

Novel materials, bioactive agents, surgical approaches, and testing modalities are being developed to address failure modes. These goals are Bigger than the Whole Sky, but not Untouchable to ensure neural interfaces last Forever and Always and appear Invisible to the tissue.

Thorough testing is critical to ensure that novel implanted neural interfaces Long Live. We describe methods for benchtop, in vivo, and post-explant testing. From this testing, it may be necessary to Change the implant design, and Begin Again, before you’re Out of the Woods.

When a complication arises from failure of an implanted neural interface, understanding the severity is critical to guide clinical decision-making. We created a system to grade the severity of these complications, including examples. Upon treatment, Soon You’ll Get Better.

The End Game is clinical translation of implanted neural interfaces. Importantly, failure modes have clinical implications and risks. Adverse events due to the surgical procedure, as well as those related to failure modes, are reported below for various neural interfaces.

The tissue response & micromotion contribute to neuronal degeneration and loss near the implant site. Decreased neuronal density reduces therapeutic effects because neural interfaces rely on communication between the electrodes and neurons. We are Haunted by this High Infidelity

Micromotion is subtle movement of the implant from respiration, heartbeat, or changes in blood or cerebrospinal fluid pressure. Tissue damage is worsened by implant-tissue stiffness mismatch. Sharp electrode tips evoke a strong tissue response, inducing Death by a Thousand Cuts.