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Darcy

@darcyserval

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one of god's own prototypes…too weird to live, and too rare to die | ✶ ✶ ✶ ✶ | 🔞

Chicago its/her 20
Joined October 2022
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@darcyserval
Darcy
1 year
freaktar
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@darcyserval
Darcy
3 days
NE ohio** myb y’all.
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@darcyserval
Darcy
3 days
In NW Ohio we had Tim Minsy and his billboards were so prolific and well known that they eventually just started devolving into this. I had one of the last ones staring at me through the window at my job at Subway
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@WikiOoc
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4 days
I like it when lawyer billboards are like this
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@darcyserval
Darcy
4 days
blood moon over Edgewater tonight #thereisevilinEdgewater #thereisevilinRogersPark
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@darcyserval
Darcy
5 days
I’ve been staying with a few of my Millennial friends for the last month and yeah Haus of Decline really did hit their generation like crack in the 80s.
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@darcyserval
Darcy
5 days
got bored so I turned her into a bracelet
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@darcyserval
Darcy
8 days
Ive been wanting to get into photography for like a year but was kinda intimidated then I bought my first DSLR like a month ago for $30 and it’s been cool watching myself learn how to run it and get better at composition. I’m having a blast. remember you can just do things.
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@darcyserval
Darcy
9 days
If you are of age and you want to use 7oh go ahead, but make sure you are making an informed purchase and understand the risk. I’ll say again though if you’ve never used it, it’s best you do not try it if you can help it.
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@darcyserval
Darcy
9 days
There is no regulatory oversight in the industry either. you do not need to be 21 to buy 7oh, manufactures aren’t required to put any warnings on the package, there’s no limit to the mg count per pill and pills don’t have to contain the amount stated on the packaging.
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@darcyserval
Darcy
9 days
To conclude I would like to clarify that I am not saying 7oh needs to be banned. I’m of the belief that adults can make their own *informed* decisions, but there’s a ton of deceptive marketing and a dire lack of consumer education in this industry.
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@darcyserval
Darcy
9 days
However, kratom has the same bias, and unlike 7oh it is an actual step down from pharmaceutical/street opioids and can be used to effectively taper.
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@darcyserval
Darcy
9 days
The only part of that argument that would hold water is that it is safer than pharmaceuticals as it’s a partial agonist with G-protein signaling bias over B-arrestin2. This means that it lacks the dangerous side effects of most opioids like lung depression.
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@darcyserval
Darcy
9 days
The argument that opioid addicts can use it to taper doesn’t really hold water because of its extremely short half life and the fact its potency being comparable to pharmaceutical painkillers just means you’d be replacing one addiction with another.
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@darcyserval
Darcy
9 days
The only valid use case 7oh advocates can give is that people who are addicted to hard shit can use it to taper, but in reality the majority of new 7oh customers are opioid-naive, uninformed consumers and it seems like manufactures know this and are marketing to them. i mean look
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@darcyserval
Darcy
9 days
Many people who’ve quit say that the mental withdrawals last way longer than the physical withdrawals and that it feels like they still have a chunk taken out of them even months later. This could be due to the way 7oh interacts with serotonin, but it’s not well studied.
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@darcyserval
Darcy
9 days
It’s short half life also means it’s .very hard to taper down when you’re ready to quit and a lot of users have actually had to get on suboxone or go to detox. It has horrible WDs, many say it’s comparable to withdrawing from things like oxy but with an additional mental aspect.
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@darcyserval
Darcy
9 days
It doesn’t take very long to develop a physical dependency with 7oh and tolerance builds very quickly. This combined with the fact that it is very expensive means it’s easy to find yourself trapped in a cycle where you wasting a lot of money just to not be sick.
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@darcyserval
Darcy
9 days
7oh is in fact 10-13 times more potent than morphine. This is comparable to Dilaudid. 7oh also has a half life of 1.5 to 3 hours, which means once you develop a physical dependency you have to dose nearly every hour in order to avoid getting dopesick.
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@darcyserval
Darcy
9 days
7-hydroxymitragynine is vastly different from mitragynine. The addition of the hydroxy group on the 7th position of the molecule completely alters the binding affinities and effects profile. As a result 7oh is much stronger than kratom with higher affinity for mu-opioid receptors.
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@darcyserval
Darcy
9 days
7oh is not kratom. there’s a misconception that 7oh products are extracts like the mitragynine shots. Yes, 7oh is found in the kratom plant naturally but in trace amounts. The majority of the 7oh in this pills is produced synthetically.
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@darcyserval
Darcy
9 days
there’s a lot of misinformation going around about 7oh and a lot of info that 7oh advocates and manufactures are neglecting to talk about so I feel like I should tell yall if you haven’t heard already: be very careful with 7oh and if youve never used it, don’t if you can help it.
@kratomscience
Kratom Science
9 days
Just announced: FDA will recommend scheduling 7-hydroxymitragynine as a controlled substance to the DEA.
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