Min Cui, MD @UHCMC/Case Western Path
@cui_min_GI_path
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I'm happy to share that this paper has been accepted by Human Pathology. Not entities that you see every day with pancreas biopsy (thankfully), but helpful to keep the differential in your mind.
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Malakoplakia, more commonly seen in GU system, can be seen in GI tract too. The abundant histiocytes in lamina propria can raise the differential diagnosis of a poorly differentiated neoplasm. CD68 highlights the histiocytes in this case.
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Colon polyp. Special stain is Von Kossa. Happy holidays everyone!
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Solid pseudopapillary neoplasm, Positive for Beta-Catenin nuclear staining.
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Pancreatic mass, H&E and what is the immunostain? Answer in reply
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Gangliocytic paraganglioma (New WHO name: Composite gangliocytoma/neuroma and neuroendocrine tumour). Mixture of three type cells with epitheloid, spindle cell and ganglion type cells of varying proportions.
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2cm submucosal nodule in second portion of duodenum, close to ampulla, 1st picture from biopsy, the rest from excision. Immunostain is S100. Dx in reply
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First real case I encountered. Dr.Christina Arnold has a nice paper about this entity: Am J Surg Pathol. 2018;42(10):1317-1324.
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Biopsy of gastric mucosa with cobblestone appearance, rule out malignancy. AFB negative. Infor about diagnosis in reply.
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Esophagus ulcer biopsy, H&E showing 3 M (molding of nuclear contours, margination of chromatin and multinucleation) and HSV immunostain (not required for diagnosis in this case).
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Whipple disease. Lamina propria expanded by histocytes expanded by microorganism that's positive for PAS-D and negative for AFB. Fairly uncommon.
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Ileum biopsy from a patient with diarrhea, H&E images and PAS-D, AFB is negative. Diagnosis in reply section
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Mycobacterium avium, the histiocytes contain abundant microorganisms that are positive for PAS-D and AFB.
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Duodenal biopsy of an immunocompromised patient, H&E pictures, special stains are PAS-D and AFB. diagnosis posted in the reply section.
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Mucinous cystic neoplasm of pancreas with ovarian type stroma and associated invasive adenocarcinoma
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GE Junction nodule. Granular cell tumor. Immunostain S100
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