Chris Jackson Profile
Chris Jackson

@cjackstats

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Senior Investigator Statistician at the MRC Biostatistics Unit, University of Cambridge. Also at https://t.co/J9glTsCC5M https://t.co/mpsAfcK08O

Cambridge, England
Joined November 2017
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@cjackstats
Chris Jackson
2 years
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@cjackstats
Chris Jackson
2 years
Written by a large bunch of great people, edited by Anna Heath, @NataliaKunst and me, and comes with an R package to use the methods at
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@cjackstats
Chris Jackson
2 years
Value of Information methods are used to determine the most important uncertainties in a complex model, and what we would gain from getting better information. They have been used a lot in health economics, but are more widely applicable. Based on Bayesian decision theory.
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@cjackstats
Chris Jackson
2 years
...Nearly forgot to add, I'm doing a talk about the survextrap package next week at RSS Northern Ireland https://t.co/AWBV21PDr1 . Teams link
rss.org.uk
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@cjackstats
Chris Jackson
2 years
The package should also be useful as an easy way to fit a flexible Bayesian survival model in general, even if you don't need extrapolation. It is inspired a lot by rstanarm , and tweaks the model in https://t.co/OyaF2Orlfi in various ways to facilitate extrapolation.
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@cjackstats
Chris Jackson
2 years
Hoping people will try it and use it. Please feed back, in particular if you would like to use it, but something about it looks too hard! The idea is to make principled methods easily accessible.
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@cjackstats
Chris Jackson
2 years
You can (a) build in multiple data sources (e.g. trial, registry, population, elicited...) in a general format (b) fit models with a single command, (c) output results with a single command, in a friendly tidy format.
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@cjackstats
Chris Jackson
2 years
So the model output is a posterior which says what your data says, and represents uncertainty properly if there is no long-term data.
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@cjackstats
Chris Jackson
2 years
The paper introduces an R package https://t.co/joidaieqL1 that does all this. It uses a flexible Bayesian model, fitted with https://t.co/Hi6venW62F. The "hazard" of death is allowed to vary over time using a spline, and can vary smoothly outside the data.
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@cjackstats
Chris Jackson
2 years
Ideal tool would be able to (1) combine several data sources (2) fit it all well (3) acknowledge uncertainty where data are weak. And not forgetting: (4) be easy to use!
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@cjackstats
Chris Jackson
2 years
Health policy decisions often involve "extrapolating" short term data from trials. To do this properly, we have to build in long term information. There's been lots of methods papers on the topic, but no ideal tool.
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@cjackstats
Chris Jackson
2 years
Announcing a new paper "survextrap: a package for flexible and transparent survival extrapolation" https://t.co/gpQCutCHJ2 . Proud of this, as I've been interested in the problem for many years, but only recently had time to get stuck into a solution. Tweet summary below.
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@cjackstats
Chris Jackson
2 years
Learn Bayesian statistics with us, wherever in the world you are!
@MRC_BSU
MRC Biostatistics Unit
2 years
Our short course on Bayesian Statistics introduces Bayesian statistical methods and provides skills for designing, assessing and interpreting Bayesian analyses. 17 Nov - 1 Dec, online. Register 👇 https://t.co/xNXSGFyNhi @rjbgoudie @apresanis @cjackstats
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@rjbgoudie
RJB Goudie
2 years
3yr postdoc job opportunity @MRC_BSU @Cambridge_Uni in Bayesian methodology Potential topics/directions: computational methods for data integration/Markov melding; methodology for prior specification; methods for multi-stream EHR data Closes 6 Nov https://t.co/vBl96y0REP
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@cjackstats
Chris Jackson
2 years
(A department neighbouring the one that I work in, I meant to say)
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@cjackstats
Chris Jackson
2 years
If you like multistate / survival modelling you may be interested in this position https://t.co/QLZSd5xECX collaborating with some good people in a neighbouring department.
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@cjackstats
Chris Jackson
2 years
Not that I think this was a highlight of #RSS2023Conf, but slides from my talk about survival extrapolation are linked from
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@cjackstats
Chris Jackson
2 years
Coming to the end of an enjoyable three days of #RSS2023Conf . Too much good science and people to pick highlights, just generally feeling that stats and statisticians are alright!
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@MedDecMak
Medical Decision Making
3 years
"At first I was afraid, I was petrified"... An innovative method to the problem of extrapolating survival curves from heavily censored trial data: @ZhaojingC, @gianlubaio, @n8thangreen https://t.co/kARpkLDuJy
Tweet card summary image
journals.sagepub.com
Background Survival extrapolation is essential in cost-effectiveness analysis to quantify the lifetime survival benefit associated with a new intervention, due ...
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