Luong et al. reveal how genetic variation affects autosomal random monoallelic expression (aRME) of Pvt1 via differential TFAP2a binding. The stochastic allelic choice for aRME is propagated through...

Liu et al. report chromosome-level genomes of 11 species across 10 Polygonaceae genera (including four previously published genomes), which encompass diverse habitats. Integrating genomic and...

Li et al. reveal how the spike proteins of Getah virus, an arthropod-borne alphavirus, are modified by fatty acid attachment. They identify the acyltransferase DHHC11 as a key host enzyme required...

Singh et al. show that TMZ treatment in glioblastoma induces ATR- and PNPT1-dependent degradation of miR-181d. Loss of miR-181d de-represses PNPT1, establishing a feedforward loop that amplifies...

Only a small number of barrier-enhancing factors have been discovered to specifically increase barrier integrity, enhance vessel stability, and make vessels resistant to fluid leakage. Here, Fahey et...

Miller et al. use fMRI to demonstrate that human hippocampal CA2/3 subfield damage results in retrograde autobiographical amnesia and destabilized frontal autobiographical mnemonic representations....

Santos-Ferreira et al. established a gastric organoid biobank from normal, adjacent, and tumor tissues to assess glycosylation fidelity. Organoids recapitulate tissue-specific glycosylation, preserve...

Zhan et al. show that blood vessels serve as a migratory scaffold directing retinal microglial precursor infiltration into the developing retina. Vascular Lamb1 signaling orchestrates this precise...

Dimitrov et al. report that the calcium channel TRPC6 enables TNBC cells to evade ferroptosis by repressing c-Myc to sustain glutathione levels. This channel has a causal role in metastasis, and its...

Despite bifidobacteria playing essential roles in human and infant health, large-scale studies of their interactions with phages are scarce. Docherty et al. uncover a diverse repertoire of antiviral...

Li et al. report that ID1 sustains STING activation and innate immunity by blocking PRMT5-STING binding, thereby preventing PRMT5-mediated methylation at Arg281 of STING. The PRMT5 inhibitor EPZ015...

Mori and colleagues show that the integrated stress response (ISR) cascade triggered in the postsynaptic muscle of the Drosophila larval neuromuscular junction (NMJ) by acute amino acid restriction...

How traumatic brain injury (TBI) mechanistically contributes to neurodegenerative disease remains poorly understood. Marco et al. find that therapeutic viral vector-based delivery of VEGFC recupera...

The prevalence of obesity has led to significant interest in identifying the molecular mediators of adipose tissue expansion. In a recent issue of Cell Reports, Renzi and colleagues reveal a new...

MLL3 is frequently mutated across cancers. Liu et al. reveal that these mutations are associated with enhanced immune infiltration, predicting improved survival and immunochemotherapy response in...

Synthetic lethal paralogs have long been known, yet most paralog interactions are untested. Flister et al. report a screen of 36,648 known human paralog pairs. These data combined with a meta-analy...

(Cell Reports 44, 115207; January 28, 2025)

Wang et al. systematically depicted the lamins-guided 3D epigenome in human stem cells and demonstrated that lamins not only serve as key regulators of chromatin-NL tethering and large-scale genome...

Zuo et al. show monocyte-derived cells as key contributors to transient insult-induced brain injury. These cells infiltrate lesions, exhibit antigen-presenting features, and promote CD8+ T cell...