Cell Reports Medicine
@CellRepMed
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Broad-scope #OA journal from @CellPressNews publishing cutting-edge science across the spectrum of #Translational and #ClinicalResearch | Editor: @DrSaraHam
USA, NLD, CHN, GBR, BEL
Joined October 2019
On the Cover: A gardener removes weeds among flowers—just like therapies targeting the tumour microenvironment can eliminate cancer cells while sparing healthy ones. Dive into our special issue for expert reviews on immune cell targeting in cancer! Artwork by Justine Reimand.
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Online now: Nonsense-mediated mRNA decay inhibits TRAF6-dependent anti-tumor immunity in colorectal cancer
cell.com
Wang et al. demonstrate that nonsense-mediated mRNA decay (NMD) is abnormally activated in CRC. Inhibiting NMD remodels the tumor microenvironment by activating the TRAF6-TBK1 axis and boosting CD8+...
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Online now: Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury
cell.com
Zhou et al. show that activation of Ngn2 and Isl1 enabled reactive astrocytes to convert into neurons, which promotes functional recovery after spinal cord injury, with new neurons forming synaptic...
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Online now: Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning
cell.com
Jin et al. integrate drug sensitivity testing, transcriptomics, and functional assays to uncover key determinants of venetoclax-azacitidine (VEN/AZA) response in AML. They develop an eight-gene model...
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Online now: Unlocking the tumor microenvironment: Innovative strategies for cancer therapy and translational insights
cell.com
The tumor microenvironment (TME) is a highly complex and dynamic ecosystem composed of diverse cellular and extracellular components that critically influence cancer initiation, progression, and...
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Online now: Voices: Future directions in targeting the tumor microenvironment
cell.com
What do you envision as the most promising future directions for therapeutic strategies aimed at modulating the tumor microenvironment?
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Online now: From bench to body: In vivo CAR engineering in the clinic
cell.com
In vivo CAR engineering is an emerging therapeutic platform for cancer and autoimmune diseases. Enabled by advanced delivery systems such as immune-evasive lentiviral vectors and targeted lipid...
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Online now: From visualization to prediction: Dissecting metabolic heterogeneity with DDRTree
cell.com
The discriminative dimensionality reduction tree (DDRTree) framework provides a powerful approach to unravel metabolic heterogeneity and delineate clinically relevant subtypes. In this issue, Qiu et...
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Online now: System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells
cell.com
Everolimus is approved for treating advanced ER+ breast cancers, yet many patients develop resistance. Medina et al. identify SMARCD3 regulons linked to activation of alternate growth-factor signal...
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Discuss your gene and cell therapy research with editors from Cell Stem Cell and Cell Reports Medicine. Talk about your work and discover the best place to submit, what will help to get your work published, and what you can expect when you submit. https://t.co/GvXcL0TVHd
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Online now: A prognostic index integrating deep learning baseline PET/CT biomarkers and multi-omics profiling in diffuse large B cell lymphoma
cell.com
Wang et al. develop a clinical-imaging-multi-omics prognostic index for diffuse large B cell lymphoma by integrating quantitative PET/CT biomarkers, genetic subtypes, and clinical risk factors. By...
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Together with our partners @ZJU_China, Liangzhu Laboratory, we're thrilled to announce @CellSymposia Taking programmed cell death from mechanisms to interventions 📍Hangzhou, China 📆October 22–24, 2026 Visit our website: https://t.co/GybcikOhC1
#CSCellDeath26
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Online now: Virus envelope glycoprotein targeting bispecific T cell engager protects mice from lethal severe fever with thrombocytopenia virus infection
cell.com
Peng et al. reveal that the impaired cytotoxicity and exhausted state of T cells are significantly associated with lethal outcomes in SFTS patients and demonstrate that Gn-targeted bispecific T cell...
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Online now: Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
cell.com
Zhao et al. translationally demonstrate how maternal diabetes induces early-onset endothelial dysfunction in sons, but not daughters, even when offspring are metabolically healthy. This challenges...
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Online now: A combined genomic arrhythmia propensity score delineates cumulative risk
cell.com
Monroe et al. analyze genome sequencing from individuals with early-onset ventricular arrhythmias. Combining the effect of common genetic variants with rare coding and noncoding regulatory variants...
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Online now: Plasma proteomics identifies proteins and pathways associated with incident epilepsy
cell.com
Zhang et al. utilize large-scale plasma proteomic data to investigate the association between 2,920 plasma proteins and the risk of incident epilepsy. They characterize the temporal trajectories of...
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Online now: Gene therapy for hemoglobinopathies: Clinical trial results and biology of hematopoietic stem cell and the bone marrow niche
cell.com
In this review, Aprile et al. highlight the clinical application of gene therapy by gene addition and gene editing, and the novel findings about hematopoietic stem cell and bone marrow niche features...
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Online now: A combined genomic arrhythmia propensity score delineates cumulative risk
cell.com
Monroe et al. analyze genome sequencing from individuals with early-onset ventricular arrhythmias. Combining the effect of common genetic variants with rare coding and noncoding regulatory variants...
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Online now: Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
cell.com
Zhao et al. translationally demonstrate how maternal diabetes induces early-onset endothelial dysfunction in sons, but not daughters, even when offspring are metabolically healthy. This challenges...
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