Researchers from Laval University have found out that white collar workers who work more than 40 hours per week in midlife had higher arterial stiffness at older age as measured by carotid-femoral pulse wave velocity. https://t.co/6Gv7zPmgs5

3/3 https://t.co/l2HnQGc6dm

2/3 the addition of immunoglobulin (IG), the researchers found that biological ages were reduced according to the combination of various epigenetic clocks. This was more pronounced with the addition of IG and with those patients with poorer prior health. https://t.co/DNfbYeOTum

Replacing the blood or plasma in old animals with that from younger animals has shown promising results, but data from humans has so far been sparse. This small study starts to fill in that gap. Using three different treatment regimes, including one which also included ... 1/3

2/2 ... increased blood vessel relaxation and reduced post-operative atrial fibrillation. "In conclusion, short-term quercetin treatment effectively targeted vascular senescence in male CAD patients, improving inflammatory and functional outcomes." https://t.co/fgYkxVvC7P

Researchers from the @UMontreal found that in a randomized, double-blind trial, male patients undergoing coronary artery bypass graft surgery treated with quercetin (500 mg 2X daily) for two days pre-surgery through hospital discharge showed reduced inflammation 1/2

3/3 Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer’s disease https://t.co/PvBTeC7Xk9

2/3 ... protect memory and brain health in older adults." Nice to see more senolytic work coming out of Canada! Senolytics target Alzheimer’s-linked brain enzymes without harming healthy ones https://t.co/xHY4xAnxPs

Researchers from Dalhousie University have discovered that senolytics can target Alzheimer’s-linked brain enzymes without harming healthy ones. "This work provides new insight into how AD-related damage can be precisely targeted, leading the way for safer treatments that ... 1/3

2/2 ... sex-specific behavioral deficits linking TDP-43 SUMOylation with aging and disease" and that "SUMOylation is correlated with human aging and disease states". A stress-dependent TDP-43 SUMOylation program preserves neuronal function https://t.co/Km4Gsjw9Xj

Researchers from Ottawa University discovered new insights into the dysfunction of a protein, TDP-43, which is associated with ALS and FTD, and its regulation via a process called SUMOylation. "When this process is blocked in vivo, we note age-dependent TDP-43 pathology and 1/2

We need something similar for Canada!

2/2 "These results highlight SPARC as a potential therapeutic agent that would produce exercise-like effects, providing options for individuals who need exercise benefits but are unable to perform the required physical activity." https://t.co/dUDkkm2HL5

Researchers from the CHU de Québec-Université Laval Research Center investigated the molecule SPARC, which is produced by muscles during exercise. When injected into mice it improved their muscles metabolic function, mimicking the beneficial effects of exercise. 1/2

2/2 ... the first of which uses epigenetic reprogramming, while the second, from Canada, uses senolytics. https://t.co/QEAf6Ut0iG

March's Longevity Review is now out, where we will take a look at how low frequency ultrasound can reverse cellular senescence and increase mouse lifespan, as well as two studies on reducing lower back pain, ... 1/2 https://t.co/ZrLfqXQyra

Longevity Snapshot 11 - Senolytics to Reduce Lower Back Pain Lower back pain is one of the most common chronic conditions of aging. In this Canadian study, senolytics were used to remove senescent cells and reduce lower back pain in mice. https://t.co/byqRNHe2za

Longevity Snapshot 10 - Reprogramming To Reduce Lower Back Pain Lower back pain is one of the most common chronic conditions of aging. In this study epigenetic reprogramming is used to rejuvenate spinal cells and reduce lower back pain in rats. https://t.co/46hMWicefU

2/2 ... the effect of PA on cerebrovascular health." "Postmenopausal females showed greater reductions across more regions in cerebral pulsatility than other groups" https://t.co/ED2BwVpw69

Researchers from @Concordia University looked at the sex specific effects of physical activity on cerebrovascular health. "Overall, males and females appear to benefit from different amounts and intensities of physical activity (PA), with menopause status influencing ... 1/2