Calvin Yeang MD, PhD
@calvinyeang
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Preventative Cardiologist, Scientist, @UCSDHealth
San Diego
Joined June 2009
A7: There is hope in the next ~3 years that safe, specific and potent therapies lowering lipoprotein(a) may become available. #KnowLpa.
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A7: There are exciting therapies currently in clinical trials that prevent the liver from making apo(a) and thereby reducing lipoprotein(a) levels by ~80% at optimal doses. Pelacarsen is currently in phase III and Oliparsiran in phase II clinical trials. #Knowlpa
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A6: Clinically, the most important questions are 1) how can we continue to improve risk prediction for those with elevated lipoprotein(a) and 2) does specific lipoprotein(a) lowering reduce cardiovascular disease risk? #KnowLpa.
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A6: Despite being first described by the geneticist Kare Berg in 1963, there remains so much more to understand about lipoprotein(a). #knowlpa.
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A5: Additional biomarkers and imaging also be helpful in fulling understanding risk in those with elevated Lp(a). Interventions, such as lifestyle modification and/or pharmacologic therapies can then be tailored based on your estimated overall risk. #KnowLpa.
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A5: One way to do this was described in the AHA Scientific Statement on Lipoprotein(a) with @grsoffer, Henry Ginsberg, Lars Berglund, Barton Duell, @heffron_sean, Pia Kamstrup, @dmljmd, Santica Marcovina and @MarlysLPA. #Knowlpa .
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A5: If you have elevated lipoprotein(a), this information can be incorporated with your other risk factors to estimate your risk of developing disease. #KnowLpa.
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A4: Lp(a) levels are largely genetically determined and is passed down in families. It is inherited in an autosomal co-dominant manner, meaning that every first degree relative of someone with elevated lipoprotein(a) has a 50% chance of also having high levels.#KnowLpa
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A3 The major societal guidelines have provided recommendations on who should have lipoprotein(a) testing. There is agreement with at least a relative indication to check lipoprotein(a) in those with a personal or family history of atherosclerotic cardiovascular disease. #Knowlpa.
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A2: In addition, it is the major lipoprotein carrier of pro-inflammatory and pro-calcific oxidized phospholipids and uniquely contains a protein called apo(a) that facilitates the accumulation of lipoprotein(a) in blood vessels and valve tissues. #KnowLpa
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A2: #KnowLpa Lipoprotein(a) resembles LDL or “bad cholesterol”, and these two lipoproteins share pro-atherogenic properties.
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A1:Checking Lp(a) with a simple blood test can be important for better understanding a patient’s risk for disease but also for planning how to modify their risk. #KnowLpa @TheFHFoundation
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A1: Lipoprotein(a) is a common risk factor for heart and valve disease, peripheral arterial disease, stroke, and mortality. About 1 in 5 people have high levels of lipoprotein(a). @TheFHFoundation #knowlpa
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