Christian Ottensmeier
@c_ottensmeier
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I love to have fun with science - mainly trying to understand how the immune system ticks. I love to cook (with my boys), read and go walking with friends
Liverpool, England
Joined December 2016
. and preclinical collaboration with teams in UCL, Cambridge, and of course CRUK who funded the clinical trial and the Amgen team who made drug available.
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it is also an amazing team effort: surgical and medical oncologists from our head and neck center, a multi center clinical collaboration with our friends in Poole, Southampton, Glasgow, amazing scientists in the La Jolla institute. .
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We are super happy that our Nature paper went public yesterday. Please find the open access paper at: we believe that this is potentially a really big step on how to make combination immunotherapy better for more patients.
nature.com
Nature - A study using a mouse solid tumour model suggests that adjusting the dosing frequency of the PI3Kδ inhibitor AMG319 in the treatment of human cancers could decrease tumour growth with...
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This study was an important step in our collaboration with Transgene, and an early phase clinical trial of personalised immunotherapy in patients with head and neck cancer.
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We are very proud to report that our study "Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer" has been published in the Journal for ImmunoTherapy of Cancer.
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our story in T follicular regulatory cells recognised by AICR - very proud.
acir.org
Regulatory T cells (Treg) can differentiate into follicular regulatory T cells (TFR) that have important roles in secondary lymphoid organs and may have higher suppressive activity. However, their...
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Read this #preprint on @researchsquare: Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial
researchsquare.com
Phosphoinositide 3-kinase δ (PI3Kδ) plays a key role in lymphocytes and inhibitors targeting this PI3K have been approved for hematological malignancies. While studies in hematological and solid...
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Joe Sacco, clinician scientist just gave a wonderful talk on his work in immunotherapy in uveal melanoma. Great work, Joe.
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RT @SciImmunology: A massive single-cell #RNA sequencing analysis of 80,000+ virus-reactive killer T cells from #COVID19 patients revealed….
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RT @Labanlabgroup: New paper published in @IntJCanc analyzing immune checkpoint expression on different immune cell subsets during curative….
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RT @drkirmani: @LHCHFT thoracic audit day today. The brilliant and entertaining Prof Ottensmeier from @LivUni gave an inspiring talk about….
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