A Salah
@briefnotes81
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Internal Medicine Registrar ... Member of Saudi Society of Internal Medicine
Joined July 2025
The Endocrine Society guidelines now suggested IGF-1 measurement as the first-line test in patients presenting with typical clinical manifestations of acromegaly.
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FDA Approves LYNOZYFIC (linvoseltamab-gcpt) for Relapsed or Refractory Multiple Myeloma.
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Symptoms and signs of autonomic activation (eg, sweating and palpitations) could indicate postural tachycardia syndrome and vasovagal syncope, and the presence of emotional or pain triggers could indicate vasovagal syncope.
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RT @Doctors__squad: Poststreptococcal Pustulosis . A 47-year-old man presented to the emergency department with a 3-day history of a pustul….
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Midodrine is the only medication approved for use in the UK for symptomatic OH, if conservative measures are inadequate.
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Furthermore, “uroselectivity” of tamsulosin is not absolute, and OH risk in susceptible individuals is increased.
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RT @FDA_Drug_Info: FDA grants accelerated approval to a treatment for relapsed or refractory multiple myeloma. http….
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The Systolic Blood Pressure Intervention Trial (SPRINT) trial demonstrated that intensive treatment (systolic blood pressure target < 120 mmHg) saw a reduction in OH incidence in comparison to standard targets (systolic blood pressure < 140 mmHg).
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The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial showed that achieving tight control of systolic BP with antihypertensive treatment did not relate to incidence of OH.
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There is no clear evidence that withdrawal of antihypertensive medication leads to reduced OH as a blanket strategy.
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Regular physical activity plays a key role through maintaining myocardial and vascular compliance.
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Alcohol consumption can be detrimental due to impaired vasoconstriction and short-term diuretic effects with neurotoxicity over the longer-term.
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