Early effect of semaglutide on the primary outcome occurred early, before the 65 week plateau in weight loss, raising the questions - what is the mechanism of CV benefit, and how much benefit is mediated by weight loss? #AHA23 Tweet added by Brendon Neuen @brendonneuen

Brendon Neuen

7 months

Early effect of semaglutide on the primary outcome occurred early, before the 65 week plateau in weight loss, raising the questions - what is the mechanism of CV benefit, and how much benefit is mediated by weight loss? #AHA23

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Abdelhamid Hamdy

@abdelhamed012

7 months

@brendonneuen can it increase Coronary Calcification Score

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Rhianna Miles

@DrRhianna

7 months

@brendonneuen Clearly the hormonal and energy usage effects are what cause CV benefit in these (and SGLT2i)

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Das

@shivadas29

7 months

@brendonneuen Prevention of new onset t2d I guess

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