Victor V. Lobanenkov
@boris_ctcf
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Verifiable facts and personal notes related to paralogous CTCF & CTCF Like BORIS factors which share eleven near-identical DNA\RNA\protein-binding Zn fingers
Maryland, USA
Joined March 2011
⚠️ CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation. Published July 4th 2025 (today) .
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DeepMind’s new AlphaGenome AI takes long (1MB) stretches of DNA to predict various properties such as the expression levels of the genes they contain, how those levels could be affected by mutations, and even 3D DNA loops of enhancer-promoter links, etc.
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CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation. M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva. revised May 23, 2025.
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New moon of June 2025 sees Mercury climb to its highest point in the sky
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CTCF maintains pericentromere function and mitotic fidelity. Preprint posted on bioRxiv (June 3, 2025) by Erin Walsh and Andrew Daniel Stephens
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Deciphering the role of RNA in regulating DNA binding CTCF affinity in chromatin. Genome Biology paper (May 12, 2025) published by Judith Hyle et al.
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CTCF-binding silencer in the WT1 anti-sense regulatory region (WT1 ARR) regulates imprinting of AWT1 and WT1-AS genes, and exhibits sequential epigenetic defects during Wilms’ tumor genesis. Hum Mol Genet 2007 paper by Anne Hancock and coauthors from V. Lobanenkov & K. Malik labs
Post-fertilization initiation of anti-sense transcript in ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 in rabbits and macaques. eLIFE publication (June 2, 2025) by Hisato Kobayashi, corresponding author and 22 coauthors
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Post-fertilization initiation of anti-sense transcript in ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 in rabbits and macaques. eLIFE publication (June 2, 2025) by Hisato Kobayashi, corresponding author and 22 coauthors
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BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.PNAS U S A. 2002 May 14; 99(10): 6806-11.
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Familial cases of point mutations in the XIST promoter which revealed strict correlation between CTCF binding and preemptive choices of X chromosome inactivation have already provided near direct evidence for the crucial CTCF role in Human X-inactivation.
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BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.Genome Biol. 2024 Jan 31; 25(1): 40. .
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Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity. Filippova et al Cancer Res Jan 1; 62(1): 48-52 (2002).
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Tumor-associated zinc finger CTCF mutations which selectively alter its DNA-binding specificity have been reported for the first time by Galina Filippova et. al. almost 25 years ago:.
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US reports 1st outbreak of 'highly pathogenic' H5N9 virus in poultry. Should we worry?
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Where in the World Does Lightning Strike the Most? .
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Ocean warming 4 times faster than in 1980s — and likely to accelerate in coming decades
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RT @priceyDNA: WE ARE HIRING!📢 @NIAIDCareers .Do you love #genome organization?🧬.We are seeking a new Research Fellow to help us work on #C….
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RT @CTCF_Papers: The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
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