to reverse a rare life-threatening immune condition called leukocyte adhesion deficiency in nine children.⁠ ⁠ . #genetherapy #medicine #health #biology.

“We’re curing kids of fatal diseases. It’s wonderful,” Donald Kohn at the University of California, Los Angeles told New Scientist team in May after successfully using a gene-replacement therapy.

This year has been full of good news stories about gene-replacement therapies alleviating severe genetic disorders in children, suggesting they are finally living up to their promise after a bumpy few decades.⁠ ⁠.

Gene-replacement therapies are used to correct genetic disorders that are caused by mutations in a single gene that stop it from working properly. They involve inserting new, working copies of the gene into relevant cells, typically using a virus as a carrier.⁠ ⁠

#botany #plants #biology.#bioscoolya #biotechnology #scoolya #science #sciencenews #lifescience #LifeSciences.

When CO2 concentration increases inside the plant, a second protein blocks the HT1 pathway.⁠⁠. Journal : .Stomatal CO2/bicarbonate sensor consists of two interacting protein kinases, Raf-like HT1 and non-kinase-activity activity requiring MPK12/MPK4. DOI: 10.1126/sciadv.abq6161.

Researchers at UC San Diego, USA, have discovered that plants use a two-protein system to regulate the opening of the stomata.⁠⁠In low CO2 environments, the protein, HT1, activates an enzyme which force guard cells to keep stomata open.