biorxiv_pathology
@biorxiv_pathol
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Farmers awareness and occurrence of Meloidogyne species in tomato production in central Nepal #biorxiv_pathol.
biorxiv.org
Tomato (Solanum lycopersicum) is one of the most economically important vegetables in the world. Root-knot nematodes (RKN) form a complex of species that can cause severe losses in tomatoes. Since...
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Intrinsic differences in hamster and mouse macrophage biology correlate with susceptibility to L. donovani infection #biorxiv_pathol.
biorxiv.org
The basis for differential susceptibility to Leishmania (L.) donovani infection observed in individuals remains poorly understood. Here we address this important open question comparing bone marrow...
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Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model #biorxiv_pathol.
biorxiv.org
Background: Dyslipidemia, marked by elevated LDL-cholesterol (LDL-C), is a major risk factor for coronary heart disease. Mouse models, such as Ldlr-/- mice that develop atherosclerosis and metabolic...
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Nanocarrier-driven dual targeting VCAM-1/Collagen IV enables RNA interference-mediated silencing of Smad3 and Runx2 to mitigate . #biorxiv_pathol.
biorxiv.org
BACKGROUND: Calcific aortic valve disease (CAVD) is a common malady with few treatment options other than valve replacement by surgery or transcatheter aortic valve implantation (TAVI). Endothelial...
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Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice #biorxiv_pathol.
biorxiv.org
Acute pancreatitis (AP) is a complex and potentially severe inflammatory disorder of the pancreas and is one of the most common causes of gastrointestinal hospitalization. Although environmental risk...
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EVALUATION OF PECAM-1 EXPRESSION AND MICROVESSEL DENSITY IN GASTRIC ADENOCARCINOMA: A CROSS-SECTIONAL STUDY #biorxiv_pathol.
biorxiv.org
Background: Gastric adenocarcinoma is the fifth most prevalent malignancy globally and ranks sixth in Bangladesh, representing a significant oncological and public health challenge. Gaining in depth...
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The Role of Glycosphingolipids in Autoimmune Manifestations and Myeloma in Gaucher Disease #biorxiv_pathol.
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Differential disease tolerance mediates sex-biased illness severity in sepsis #biorxiv_pathol.
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Bidirectional Crosstalk Between Sleep and Pulmonary Arterial Hypertension #biorxiv_pathol.
biorxiv.org
Background Pulmonary Arterial Hypertension (PAH) is a devastating cardiopulmonary disease characterized by pulmonary vascular remodeling due to vascular cells dysfunction. Among other clinical signs,...
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A Simultaneous Inhibition of ID1 and ID3 Protects Against Pulmonary Fibrosis #biorxiv_pathol.
biorxiv.org
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease for which novel therapeutic approaches are desperately needed. Inhibitor of DNA binding (ID) proteins are regulated by Transfo...
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Selection of a Lead Long-Acting Formulation of Ivermectin to Target Major Malaria Vectors in Western Africa: Evaluation of . #biorxiv_pathol.
biorxiv.org
Background Ivermectin, a semisynthetic endectocide from the avermectin family, has been used in mass drug administration (MDA) campaigns since the 1980s to control helminth infections. Its lethality...
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H&Enium, Applying Foundation Models to Computational Pathology and Spatial Transcriptomics to Learn an Aligned Latent Space #biorxiv_pathol.
biorxiv.org
Bridging the gap from transcriptomic to imaging data at single-cell resolution is essential for understanding tumor biology and improving cancer diagnostics. Spatial transcriptomics enables mapping...
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Deep-learning triage of 3D pathology datasets for comprehensive and efficient pathologist assessments #biorxiv_pathol.
biorxiv.org
Standard-of-care slide-based 2D histopathology severely undersamples spatially heterogeneous tissue specimens, with each thin 2D section representing <1% of the entire tissue volume (in the case of a...
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High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure #biorxiv_pathol.
biorxiv.org
Pseudoxanthoma elasticum is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactiva...
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Mouse pulmonary pathological characteristics induced by Asian-mineral dust transported with Coniothyrium fuckelii at a high altitude . #biorxiv_pathol.
biorxiv.org
Asian sand dust (ASD) events are known to transport not only mineral particles but also bioaerosols such as fungi across East Asia, posing complex respiratory health risks. Previously, we isolated...
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Hyperspectral image analysis for classification of multiple infections in wheat #biorxiv_pathol.
biorxiv.org
Plant diseases can cause heavy yield losses in arable crops resulting in major economic losses. Effective early disease recognition is paramount for modern large-scale farming. Since plants can be...
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Identification of biomarkers for ulcerative morphology in carotid atherosclerosis plaques through single-cell RNA sequencing data #biorxiv_pathol.
biorxiv.org
Background Carotid atherosclerotic stenosis (CAS) is a major risk factor for stroke, particularly when associated with ulcerative plaque morphology. However, the molecular mechanisms underlying...
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Long-chain polyphosphates induce glomerular microthrombi and exacerbate LPS-induced acute kidney injury in mouse #biorxiv_pathol.
biorxiv.org
Polyphosphates are evolutionarily conserved anionic polymers mediating pleiotropic functions in eukaryotes and prokaryotes, depending on their chain-length. Bacteria typically synthetize long-chains,...
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The Impact of Delayed Evacuation on the Quality of Human Fetal Tissue #biorxiv_pathol.
biorxiv.org
Background Digoxin and other agents are frequently administered to arrest fetal circulation before the evacuation of human fetal tissue (HFT) in pregnancy terminations to address concerns about fetal...
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Post-operative tissue fragment puzzling using histopathological vision transformer alignment HiViTAlign #biorxiv_pathol.
biorxiv.org
In pathology, reconstructing adjacent tissue parts enables an overview of the macro environment of objects like tumors. Especially, malignoma are of interest to verify invasion and resection margins,...
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