東北大生命 活性分子動態分野
@bioactmol
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東北大学 大学院生命科学研究科 活性分子動態分野のtwitterアカウントです。創薬化学、ケミカルバイオロジーの研究室です。
Joined September 2019
Diastereomeric branched-ester dBET1 analogs reveal how even subtle structural differences, such as the configuration of a methyl-bearing chiral center, can profoundly affect the permeability of PROTACs. #JMedChem
https://t.co/MZb6mlNgrG
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Latest paper in J. Med. Chem. @ACSPublications ! We discovered that #PROTAC diastereomers exhibit different membrane permeability, driven by their distinct chameleonicity.🦎 Congrats to Mazin, Eisuke, and Keigo on this great work! Check it out:
pubs.acs.org
Proteolysis-targeting chimeras (PROTACs) represent a promising therapeutic modality, but their clinical translation is often hindered by poor pharmacokinetic properties associated with their location...
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Sci. Rep.に論文出ました！ 揮発性化合物は細胞培養用マルチウェルプレート内で拡散して隣接するウェルに影響するという論文です。D3三島君が本現象に気づき、追求しました。学生ながら三島君がコレスポです! https://t.co/3ddP0vs9jk
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Congratulations to Yugo for his publication in Scientific Reports! https://t.co/FkuCThgvlh
nature.com
Scientific Reports - Well-to-well transfer of HaloTag ligand 6-chlorohexan-1-ol and formaldehyde in a multi-well plate
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Our paper "Challenges of Aufheben to Promote Druglikeness: Chemical Modification Strategies to Improve Aqueous Solubility and Permeability" is out in Journal of Medicinal Chemistry. https://t.co/9xSrpLKBvv
pubs.acs.org
A key challenge in drug discovery is to endow candidate bioactive molecules with druglike properties. However, the optimization of critical, often-conflicting physicochemical properties through...
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AI創薬企業Elix社との共同研究を開始しました。 https://t.co/DJjgy1PmfH
https://t.co/qImUzNYOD9
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石川教授と友重助教が分担執筆した書籍Trends in CNS Drug Discoveryが公開されました。Chapter 11を執筆しています。 excited to announce our contribution to the book, "Trends in CNS Drug Discovery," from Wiley. Our work is featured as Chapter 11. Check out:
onlinelibrary.wiley.com
Provides insights into the drug discovery innovations that are shaping future CNS therapies In the vast field of neuroscience, drug discovery targeting the central nervous system (CNS) presents both...
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Latest work in @ChemRxiv ! We've developed a chemical protein modification strategy that breaks down pre-formed amyloid-β fibrils, a key protein in Alzheimer's disease. Also, this method can create aggregation-resistant insulin. Dive into the details:
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This paper has been highlighted as a Featured Article!
Congratulations to Yushi, Junki, and Naohiro for their publication in Chem. Pharm. Bull. https://t.co/u5zPzn7fsD
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Congratulations to Yushi, Junki, and Naohiro for their publication in Chem. Pharm. Bull. https://t.co/u5zPzn7fsD
jstage.jst.go.jp
Lipids, including fatty acids and phospholipids, play crucial roles in biological systems and are widely utilized in pharmaceutical and biomedical app …
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石川教授、友重助教が分担執筆した書籍が発行されました。２つのトピックを担当しています。 タンパク質分解医薬の実用化に向けた基盤技術と評価 | CMCリサーチ https://t.co/8nJyzOnw9Y
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友重助教が、東北大学Research Showcaseで講演します。 https://t.co/ExMbMSDlbH
link-j.org
東北大学オープンイノベーション事業戦略機構では､企業と大学の共創のきっかけを提供する場として｢東北大学Research Showcase｣を企画し､本学の研究リソースを紹介しています。
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