
bioRxiv Bioengineering
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Bioengineering preprints | not affiliated with bioRxiv | maintained by @MichaelRetchin
Joined April 2021
Hybrid peptide DNA nanomaterials enable potent and broad-spectrum virus neutralization . #biorxiv_bioE.
biorxiv.org
The continued emergence of antigenic drift and drug-resistant viral strains highlights the need for antiviral strategies that deliver robust efficacy, broad subtype coverage, and minimal off-target...
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Development of ultrasound molecular contrast agents by site-specific conjugation of gas vesicles to antibodies . #biorxiv_bioE.
biorxiv.org
Ultrasound technology is a powerful tool for medical imaging and diagnosis especially when used in conjunction with a contrast agent to target proteins of interest. However, current ultrasound...
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The Dayhoff Atlas: scaling sequence diversity for improved protein generation . #biorxiv_bioE.
biorxiv.org
Modern biology is powered by the organization of biological information, a framework pioneered in 1965 by Margaret Dayhoff's Atlas of Protein Sequence and Structure. Databases descended from this...
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Multi-scale Engineered Vasculature and Hierarchical Porosity via Volumetric Bioprinting-guided Photopolymerization-induced Phase Separation . #biorxiv_bioE.
biorxiv.org
Vascularization remains a major challenge in hydrogel-based engineered tissues due to the inherent nano-scale porosity of common synthetic and natural biomaterials. Critically, the confinement...
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A Microphysiologic Model of the Cervical Epithelium Recapitulates Microbial, Immunologic, and Pathogenic Properties of Sexually Transmitted Infections . #biorxiv_bioE.
biorxiv.org
Sexually transmitted infections (STIs) of the cervicovaginal mucosa are among the most common global infections. Clinical studies have revealed that susceptibility to STIs and the subsequent host...
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A Supramolecular Self-assembly Approach to Site-Specific Antibody Conjugates via a Coiled-coil Peptides Platform . #biorxiv_bioE.
biorxiv.org
Antibody conjugates play a central role across multiple healthcare sectors with a prime example being antibody-drug conjugates (ADCs). Although widely used lysine and hinge cysteine conjugation...
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Mechanically Tunable DNA Hydrogel Microparticles for 3D Cellular Systems . #biorxiv_bioE.
biorxiv.org
Hydrogel microparticles (HMPs) are powerful tools to study and manipulate cellular behavior in 3D cell culture systems and animal models. Here, fully DNA-based HMPs are presented, whose material...
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Harmonic Amplitude-Modulated Singular Value Decomposition for Ultrafast Ultrasound Imaging of Gas Vesicles . #biorxiv_bioE.
biorxiv.org
Ultrafast nonlinear ultrasound imaging of gas vesicles (GV) contrast agents promises high-sensitivity biomolecular visualization with applications such as targeted molecular imaging of tumor markers...
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The multiplier benefits of integrating non-sewered and sewered wastewater treatment and sanitation processes . #biorxiv_bioE.
biorxiv.org
This study showcases the beneficial integration of non-sewered sanitation systems (NSSS) with sewered wastewater treatment plants (WWTPs). Treating increasing fractions of influent wastewater loads...
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A PAM-CNN recognition approach to Muscle Fatigue of Special Operators by sEMG signals . #biorxiv_bioE.
biorxiv.org
Fatigue operation was the primary accident causes of large special equipment which could lead to serious economic loss and personnel injury or death, so the establishment of early fatigue warning...
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BIOCOMPATIBILITY OF LARGE-AREA 2-DIMENSIONAL ELECTRONIC MATERIALS WITH NEURAL STEM CELLS . #biorxiv_bioE.
biorxiv.org
Two-dimensional (2D) electronic materials hold immense promise for next–generation bio/neuro–electronic interfaces, but their biocompatibility has remained uncertain due to conflicting reports from...
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FLEXTAG: A Small and Self-renewable Protein Labeling System for Anti-fading Multi-color Super-resolution Imaging . #biorxiv_bioE.
biorxiv.org
Super-resolution fluorescence imaging enables visualization of subcellular structures and molecular interactions at the nanoscale, but its broader application has been hindered by long-standing...
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Engineering circular guide RNA and CRISPR-Cas13d-encoding mRNA for the RNA editing of Adar1 in triple-negative breast cancer immunotherapy . #biorxiv_bioE.
biorxiv.org
Clustered regularly interspaced short palindromic repeat Cas endonuclease (CRISPR-Cas) systems, such as RNA-editing CRISPR-Cas13d, are poised to advance the gene therapy of various diseases. However,...
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Sphingomyelinase Licensing of Mesenchymal Stromal Cells Alters Lipid and Protein Metabolites for Immunomodulation . #biorxiv_bioE.
biorxiv.org
Mesenchymal stromal cells (MSCs) are widely studied for their immunomodulatory and tissue reparative capabilities, but clinical translation has been hampered by inconsistent efficacy and limited...
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Cell-based multisensor array for detecting cancer biomarkers in human urine . #biorxiv_bioE.
biorxiv.org
Detecting volatile urinary biomarkers offers a compelling strategy for noninvasive diagnosis of diseases such as cancer. Biohybrid sensors employing sensor cells that express olfactory receptors...
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Stretching the Limits: From Planar-Biaxial Stress-Stretch to Arterial Pressure-Diameter . #biorxiv_bioE.
biorxiv.org
Understanding the physiological condition of the vascular system is critical to explain, treat, and manage vascular disease. Numerous experimental and computational studies exist to characterize the...
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Multifunctional Injectable GelMA Hydrogels with MSN-Mediated Spatiotemporal Icariin Release for Enhanced Osseointegration in Bone Defects . #biorxiv_bioE.
biorxiv.org
The repair of bone defects is faced with the dual challenges of limited autograft donors and single function of artificial materials. The development of new materials with mechanical adaptability,...
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Controlled Release of Poly(U) via Acetalated Dextran Microparticles for Enhanced Vaccine Adjuvant Delivery . #biorxiv_bioE.
biorxiv.org
Diverse drug delivery systems are needed to address challenges in delivering novel vaccine components and enhancing their efficacy. Poly(U) is a single-stranded RNA composed of uracil repeats that...
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A novel biosensor for ferrous iron developed via CoBiSe:A computational method for rapid biosensor design . #biorxiv_bioE.
biorxiv.org
Genetically encoded biosensors enable monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational approach using Constraint Network Analysis to identify optimal insert...
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HEART MURMUR DETECTION IN PHONOCARDIOGRAM DATA LEVERAGING DATA AUGMENTATION AND ARTIFICIAL INTELLIGENCE . #biorxiv_bioE.
biorxiv.org
Background: With a 17.9 million annual mortality rate, cardiovascular disease is the leading global cause of death. As such, early detection and disease diagnosis are critical for effective treatment...
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