
bioRxiv Bioengineering
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Bioengineering preprints | not affiliated with bioRxiv | maintained by @MichaelRetchin
Joined April 2021
A PAM-CNN recognition approach to Muscle Fatigue of Special Operators by sEMG signals . #biorxiv_bioE.
biorxiv.org
Fatigue operation was the primary accident causes of large special equipment which could lead to serious economic loss and personnel injury or death, so the establishment of early fatigue warning...
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BIOCOMPATIBILITY OF LARGE-AREA 2-DIMENSIONAL ELECTRONIC MATERIALS WITH NEURAL STEM CELLS . #biorxiv_bioE.
biorxiv.org
Two-dimensional (2D) electronic materials hold immense promise for next–generation bio/neuro–electronic interfaces, but their biocompatibility has remained uncertain due to conflicting reports from...
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FLEXTAG: A Small and Self-renewable Protein Labeling System for Anti-fading Multi-color Super-resolution Imaging . #biorxiv_bioE.
biorxiv.org
Super-resolution fluorescence imaging enables visualization of subcellular structures and molecular interactions at the nanoscale, but its broader application has been hindered by long-standing...
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Engineering circular guide RNA and CRISPR-Cas13d-encoding mRNA for the RNA editing of Adar1 in triple-negative breast cancer immunotherapy . #biorxiv_bioE.
biorxiv.org
Clustered regularly interspaced short palindromic repeat Cas endonuclease (CRISPR-Cas) systems, such as RNA-editing CRISPR-Cas13d, are poised to advance the gene therapy of various diseases. However,...
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Sphingomyelinase Licensing of Mesenchymal Stromal Cells Alters Lipid and Protein Metabolites for Immunomodulation . #biorxiv_bioE.
biorxiv.org
Mesenchymal stromal cells (MSCs) are widely studied for their immunomodulatory and tissue reparative capabilities, but clinical translation has been hampered by inconsistent efficacy and limited...
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Cell-based multisensor array for detecting cancer biomarkers in human urine . #biorxiv_bioE.
biorxiv.org
Detecting volatile urinary biomarkers offers a compelling strategy for noninvasive diagnosis of diseases such as cancer. Biohybrid sensors employing sensor cells that express olfactory receptors...
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Stretching the Limits: From Planar-Biaxial Stress-Stretch to Arterial Pressure-Diameter . #biorxiv_bioE.
biorxiv.org
Understanding the physiological condition of the vascular system is critical to explain, treat, and manage vascular disease. Numerous experimental and computational studies exist to characterize the...
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Multifunctional Injectable GelMA Hydrogels with MSN-Mediated Spatiotemporal Icariin Release for Enhanced Osseointegration in Bone Defects . #biorxiv_bioE.
biorxiv.org
The repair of bone defects is faced with the dual challenges of limited autograft donors and single function of artificial materials. The development of new materials with mechanical adaptability,...
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Controlled Release of Poly(U) via Acetalated Dextran Microparticles for Enhanced Vaccine Adjuvant Delivery . #biorxiv_bioE.
biorxiv.org
Diverse drug delivery systems are needed to address challenges in delivering novel vaccine components and enhancing their efficacy. Poly(U) is a single-stranded RNA composed of uracil repeats that...
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A novel biosensor for ferrous iron developed via CoBiSe:A computational method for rapid biosensor design . #biorxiv_bioE.
biorxiv.org
Genetically encoded biosensors enable monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational approach using Constraint Network Analysis to identify optimal insert...
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HEART MURMUR DETECTION IN PHONOCARDIOGRAM DATA LEVERAGING DATA AUGMENTATION AND ARTIFICIAL INTELLIGENCE . #biorxiv_bioE.
biorxiv.org
Background: With a 17.9 million annual mortality rate, cardiovascular disease is the leading global cause of death. As such, early detection and disease diagnosis are critical for effective treatment...
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Physics-Informed Generative Model for 3D Localization Microscopy . #biorxiv_bioE.
biorxiv.org
Localization microscopy techniques have overcome the diffraction limit, enabling nanoscale biological imaging by precisely determining the positions of individual emitters. However, the performance...
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Chemical Stimulation Sustains Bioluminescence of Living Light Materials . #biorxiv_bioE.
biorxiv.org
Bioluminescence offers a powerful tool for real-time, label-free sensing for living materials. However, conventional approaches often rely on mechanical stimulation, which is difficult to standardi...
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Engineering macrophage responses through 3D scaffold microarchitecture . #biorxiv_bioE.
biorxiv.org
Biomaterial implantation in living organisms triggers a physiological response known as foreign body reaction, leading to the recruitment of macrophages, that can polarize either into a pro-inflamm...
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Engineered ADARs enable single-nucleotide resolution DNA A-to-G editing without bystander effects . #biorxiv_bioE.
biorxiv.org
The adenine base editor (ABE), which enables A·T-to-G·C base conversion, has emerged as a powerful tool for therapeutic applications. However, conventional ABEs suffer from bystander nucleotide...
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Predicting DNA origami stability in physiological media by machine learning . #biorxiv_bioE.
biorxiv.org
DNA origami nanostructures offer substantial potential as programmable, biocompatible platforms for drug delivery and diagnostics. However, their structural stability under physiological conditions...
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Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer . #biorxiv_bioE.
biorxiv.org
The incidence of sporadic early onset colorectal cancer (EO CRC, under 50 years of age) is rising rapidly, yet the causes behind such rise remain poorly understood. Epidemiological studies indicate...
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Compensatory placental hypervascularization in a rat model of early-stage, diet-induced maternal obesity . #biorxiv_bioE.
biorxiv.org
Objective: Maternal obesity is usually associated with placental hypovascularity. This study aimed to challenge this paradigm by investigating the immediate vascular adaptations in the placental...
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Enabling Organ- and Injury-Specific Nanocarrier Targeting via Surface-Functionalized PEG-b-PPS Micelles for Acute Kidney Injury . #biorxiv_bioE.
biorxiv.org
While nanomedicine holds great promise for kidney disease, targeted delivery remains a major challenge. Most nanocarriers rely on passive accumulation or epithelial-specific ligands, limiting their...
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Enabling supratheoretical isopropanol yields from carbon-negative glucose fermentations with Clostridium acetobutylicum-Clostridium ljungdahlii cocultures . #biorxiv_bioE.
biorxiv.org
Synthetic microbial cocultures, which combine the unique capabilities of multiple microbes into one process, have significant potential for sustainable production of fuels and chemicals. Most studies...
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