The ATLANTIS IBS Trial
@atlantisIBS
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In a trial of 463 primary care patients in England, amitriptyline was shown to be superior to placebo in key IBS therapeutic measures. Sharing the good news!
Joined April 2025
What about side effects? The ATLANTIS trial showed low-dose amitriptyline was well-tolerated. While some anticholinergic effects were noted (e.g., dry mouth), they were generally mild and manageable via patient self-titration. Favourable risk/benefit profile. See
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IBS is more than your gut - it's your quality of life. The ATLANTIS trial showed low-dose amitriptyline can help you get back to living with fewer interruptions from pain & discomfort. Talk to your doctor or visit for more. @nihrresearch.@ukgastrodr
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The ATLANTIS trial confirms low-dose amitriptyline's role in managing IBS. At low doses, its primary effect is on visceral hypersensitivity, not mood, offering a neurological approach for refractory symptoms. Visit @nihrresearch.@ukgastrodr.@gutscharityuk
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Looking for a trusted IBS treatment? The ATLANTIS trial was a major NIHR-funded study with 460+ people. Over 60% on low-dose amitriptyline saw significant improvement. Backed by science. See for more info. @nihrresearch.@ukgastrodr.@gutscharityuk
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Low-dose amitriptyline shows clear superiority over placebo for IBS (61.3% vs 45.1% reported significant improvement). Funded by the NHS, the ATLANTIS trial provides robust evidence for this second-line treatment. See the data for yourself: @nihrresearch
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IBS symptoms can change daily. The ATLANTIS trial showed patients could gradually adjust their own amitriptyline dose, giving them more control. Flexible treatment that adapts to you. Visit for more info. @nihrresearch.@ukgastrodr.@gutscharityuk
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RT @atlantisIBS: Struggling with IBS patients who fail to respond to first-line therapies? Don't forget the evidence for low-dose amitripty….
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Struggling with IBS patients who fail to respond to first-line therapies? Don't forget the evidence for low-dose amitriptyline. The ATLANTIS trial (n=463) provides compelling RCT evidence for this effective, safe, and inexpensive second-line option. Read the paper:
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When first-line treatments prove ineffective, bring your IBS patients relief with low-dose amitriptyline. The robust ATLANTIS trial (n=463) demonstrates significant improvements in global IBS symptoms AND abdominal pain, compared with placebo. See the trial's website for more:
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Tried everything for your IBS? The ATLANTIS trial found low-dose amitriptyline could help when other treatments don't. A new, evidence-based option for persistent symptoms. Ask your GP or visit the trial's website:
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Looking to improve outcomes for refractory IBS without increasing consultation time? The ATLANTIS trial protocol empowers patients with self-titration of low-dose amitriptyline, a NICE-recommended therapy. See for details
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Low-dose amitriptyline shows clear superiority over placebo for IBS (61.3% vs 45.1% reported significant improvement). Funded by @NIHRresearch, the ATLANTIS trial provides robust evidence for this second-line treatment. See the data for yourself:
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RT @atlantisIBS: ⚕️ The ATLANTIS trial treatment protocol allows patient self-titration of low-dose amitriptyline, reducing consultation bu….
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🔑 Looking for effective next steps after first-line IBS therapies fall short? The ATLANTIS trial provides compelling evidence for low-dose amitriptyline as a second-line approach. This underutilised option significantly improves global IBS symptoms AND abdominal pain. A
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@GutsCharityUK @IBSnetwork @GastroRes @RCPhysicians @rcgp @AmCollegeGastro @gastroendonews @shefgastro @BritSocGastro @Gut_BMJ This might be of interest - could you help us spread the word?.
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📈 When first-line treatments prove ineffective, bring your IBS patients relief with low-dose amitriptyline. The robust ATLANTIS trial (n=463) demonstrates significant improvements in global IBS symptoms AND abdominal pain, compared with placebo. See the trial's website for
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⚕️ The ATLANTIS trial treatment protocol allows patient self-titration of low-dose amitriptyline, reducing consultation burden while improving outcomes. Well-tolerated with manageable side effects, it empowers patients and delivers results.
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RT @IBSnetwork: 💙 The IBS Network will close in June. Thank you for your support — more soon on how Guts UK will continue helping those wit….
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