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anna brogan Profile
anna brogan

@apbrogan

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PhD student into bacteria & coffee. Rudner lab @harvardmed. @penn_state alum.

Boston, MA
Joined May 2019
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@apbrogan
anna brogan
23 days
Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope.
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@apbrogan
anna brogan
10 days
RT @JorgStulke: The SubtiWiki Paper of the month for June 2025 has been selected! .Congratulations, @apbrogan @ @harvardmed .@NatureMicrobi….
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@apbrogan
anna brogan
23 days
RT @NatureMicrobiol: Out Now! Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis https://t.co/….
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@apbrogan
anna brogan
23 days
This was a great collaboration with Dr. Paola Bardetti and Dr. Rico Rojas at NYU. With their help, we provide evidence that c-di-AMP functions to control the cytoplasmic turgor pressure. The c-di-AMP mediated reduction in turgor protects cells from lysis.
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@apbrogan
anna brogan
23 days
In short, there is: the cyclase/regulator complex CdaAR upregulates cyclic-di-AMP in response to defects in cell wall synthesis. Similar to other envelope stress response systems in B. subtills, the cyclase regulator CdaR uses an intrinsically disordered region to sense defects.
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@apbrogan
anna brogan
23 days
c-di-AMP has long been implicated in resistance to cell wall targeting antibiotics. We hypothesized that there could be a regulatory connection between the cell envelope and c-di-AMP levels.
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@apbrogan
anna brogan
4 months
RT @ernstschmidd: Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier….
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@apbrogan
anna brogan
5 months
RT @BostonBacteria: SAVE THE DATE ‼️ 📆 📢.BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Pet….
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@apbrogan
anna brogan
5 months
Angelika Gründling’s work from her sabbatical in the Bernhardt-Rudner labs is out! She came with the goal of finding the missing G+ phosphatidylglycerol phosphate phosphatase and found it with time to spare. I can also highly recommend her as a bay mate!
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@apbrogan
anna brogan
6 months
RT @tjflemin: Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically….
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@apbrogan
anna brogan
9 months
RT @ThomasMBartlett: The Bartlett Lab is open for business at the Wadsworth Center! We study pathogens with "unusual" shapes (balls & corks….
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@apbrogan
anna brogan
10 months
I had a lovely time getting to hear some fantastic talks and share my own work at the John Innes Centre yesterday! So much exciting microbiology happening.
@JohnInnesCentre
John Innes Centre
10 months
We’re excited to be kicking off our Early Career Microbiologists Symposium 2024 🌟. Following an introduction from Graham Moore, JIC Director, our morning session is chaired by @SusanSchlimpert and begins with a talk by Anna Brogan @harvardmed
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@apbrogan
anna brogan
11 months
RT @ernstschmidd: Make publication ready figures from your #AlphaFold PAE files. Works on multimer and AlphaFold 3 files. Customize colors….
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@apbrogan
anna brogan
1 year
RT @ernstschmidd: Interactively browse all the predicted structures here:
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@apbrogan
anna brogan
1 year
RT @ernstschmidd: Excited to share that our new preprint is out! We used #AlphaFold multimer to screen 7000+ nuclear proteins to find new n….
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@apbrogan
anna brogan
1 year
another great year for @BostonBacteria! huge shoutout to all of the presenters, the OC, and to @LaurentDubois99 and Molly Sargen for running the whole show (& for incredible crisis management when BBM went dark)
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@apbrogan
anna brogan
1 year
RT @ernstschmidd: Riding the #AlphaFold3 wave with a new analysis tool. It’s super new/unpolished, but would love to get community feedback….
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@apbrogan
anna brogan
1 year
RT @maxjaderberg: Super excited to be releasing AlphaFold 3 today, developed by @IsomorphicLabs and @GoogleDeepMind: our next generation AI….
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@apbrogan
anna brogan
1 year
RT @EvolvedBiofilm: Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis. @….
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@apbrogan
anna brogan
1 year
Impressive work on a classifier to distinguish likely true AF-multimer predictions from false positives. A bacterial classifier next please!.
@ernstschmidd
Ernst Schmid
1 year
My work in Johannes Walter’s lab on developing a classifier to score AF-multimer predictions (alongside a large scale screening effort) is out as a preprint now! @Johanne23743184.
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