Anna Huang
@annash128
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Thanks for highlighting our work @NIMHgov ! https://t.co/illQ5Bpgxv
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🚨We are hiring a ⭐️Research Assistant⭐️ to run rTMS 🧲🧠 clinical trials in people with substance use and psychosis @VUMCPsych ! RAs get lots of clinical contact and experience with neuromodulation! Great for someone applying to MD or PhD programs!
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So excited about our newest collaborative work coming out of the Thalamus Conte Center Projects https://t.co/Dac6TFDWrR The work connects executive dysfunction in schizophrenia with altered thalamocortical connectivity.
cell.com
Schizophrenia impairs reasoning and is linked to abnormal interactions between the prefrontal cortex and the mediodorsal thalamus. Huang, Wimmer et al. use behavioral tasks and neuroimaging to...
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11/ For those interested in the details, you can read our full paper published in Cell Reports Medicine here: https://t.co/K3g78GbjIn. We look forward to your thoughts and discussions! 📖💬 #Schizophrenia #Neuroscience #MentalHealthResearch 11/11
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10/ We hope our research paves the way for future studies to explore these neural pathways further and develop strategies to enhance cognitive function in individuals with schizophrenia. 🧩🔍 10/11
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9/ Our study provides new insights into the neural mechanisms underlying cognitive deficits in schizophrenia, highlighting the importance of the MD-PFC circuits. This opens up potential avenues for targeted treatments and interventions. 🌟 9/11
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8/ The final experiment showed a direct role of the MD-PFC network in processing rule conflict by examining functional connectivity during a go-no-go rule reversal task in an independent sample of healthy individuals. 🚦🔄🧠 8/11
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7/ To further validate the MD-PFC network's role in conflict processing in schizophrenia, we examined MD-PFC connectivity in an independent dataset. Performance in a working memory task with a conflicting component was associated with MD-PFC connectivity. 🔍✅ 7/11
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6/ We found that uncertainty thresholds were linked to resting state functional connectivity within the right MD-PFC network, highlighting the connection between MD-PFC connectivity and sensory uncertainty processing. 📊🧠 6/11
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5/ In the first experiment, we examined sensory uncertainty using a novel decision-making task, translated from our work in mice and tree shrews. Schizophrenia participants showed deficits similar to those in mice after MD inactivation. 🐁🌳 5/11
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4/ Across three experiments, we showed that MD-PFC connectivity is implicated in processing conflicting information during executive functioning. 🧪🔬 4/11
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3/ Conflict processing, a key component of executive functioning, involves detecting and resolving conflicts in information or actions. This ability is essential for everyday functioning, enabling adaptive behavior and decision-making. 🤔💭 3/11
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2/ Cognitive impairment is a core feature of schizophrenia, significantly affecting functional outcomes and quality of life. Understanding the neural mechanisms underlying these cognitive deficits is crucial for developing effective interventions. 🧠💡 2/11
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🧵1/ Excited to share our latest research conducted with our collaborators Michael Halassa and Ralf Wimmer! Our new paper reveals deficits in conflict processing in schizophrenia dependent on MD-PFC circuits. @HalassaLab @WoodwardLab
https://t.co/K3g78GbjIn 1/11
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The UCLA Department of Psychology invites applications for a full-time, tenure-track Assistant Professor specializing in affective neuroscience. Apply!
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Thank you to @VUMChealth for the fabulous writeup 📰 of our recent @BiologicalPsyc1 paper 🧠 with @roscoebradyjr @EveLewandowski We're very excited at the prospect of circuit-based interventions for psychosis 🧲 @VUMCPsych @VUMCResearch
news.vumc.org
Vanderbilt researchers observed that, in individuals with psychotic disorders, cognitive impairment is linked to brain network organization.
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Beyond excited to share this new paper in @BiologicalPsyc1 identifying 🌟reproducible🌟 brain correlates 🧠of cognitive performance in psychosis that is the product of years of work, 27 coauthors 🥵, and the unparalleled mentorship of @roscoebradyjr
New Work! Reproducible BWAS in *tiny* samples. @hbwardMD, @EveLewandowski, and I use BWAS to link cognition and functional connectivity in individuals with psychotic disorders and then show these links can be observed years *prior to diagnosis* (1/13) https://t.co/ADsAyfhhi1
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Opportunity alert!! Grad students, early-career MH clinicians & researchers! Check out ADAA Career Development Leadership Program (CDLP). Mentorship, networking, conference registration, & a $500 cash award. To apply: https://t.co/Fal3T0yuE1 DM w/ any q’s about my experience!
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⚡️🧲🎯SO excited our panel "Hit Me with Your Best Shot: Personalized Targeting of Neuromodulation for Substance Use Disorders" was accepted by @ACNPorg featuring research from @EkhtiariHamed @tekramos, @Dr_VRSteele, & myself, chaired by @drtonypgeorge66 & @brainstimgrl
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