Amyloidosis_papers
@amyloid_papers
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Hi, I'm a bot that tweets the latest in #amyloid research from PubMed. #amyloidosis. Creator @AvinainderSingh
Boston, MA
Joined May 2017
Our tool to detect ATTR Amyloid Cardiomyopathy from ECG images - ECGvision-ATTR - has received @US_FDA Breakthrough Device Designation! A key milestone for our science from @cards_lab, led by @Veer_Sangha_, moving closer to clinical care through @Yale-backed @ensight_ai Thanks
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PACT - Prediction of amyloid cross-interaction by threading
pubmed.ncbi.nlm.nih.gov
Amyloid proteins are often associated with the onset of diseases, including Alzheimer's, Parkinson's and many others. However, there is a wide class of functional amyloids that are involved in...
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Routine 4D Cardiac CT to Identify Concomitant Transthyretin Amyloid Cardiomyopathy in Older Adults with Severe Aortic Stenosis
pubmed.ncbi.nlm.nih.gov
Background Transthyretin amyloid cardiomyopathy (ATTR-CM) often coexists with severe aortic stenosis (AS). Although strain analysis from cardiac MRI and echocardiography was demonstrated to predict...
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Hepatic vascular changes associated with Opisthorchis felineus infection in Syrian hamsters and humans
pubmed.ncbi.nlm.nih.gov
The liver fluke Opisthorchis felineus is a foodborne zoonotic pathogen endemic to Russia, Kazakhstan, and several European countries. The adult flukes affect the hepatobiliary system of piscivorous...
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Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation
pubmed.ncbi.nlm.nih.gov
Hereditary transthyretin amyloidosis with polyneuropathy (ATTR-PN) results from specific TTR gene mutations. In this study, we generated two induced pluripotent stem cell (iPSC) lines derived from...
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Reduced early mortality with Daratumumab-based frontline therapy in AL amyloidosis: A retrospective cohort study
pubmed.ncbi.nlm.nih.gov
Reduced early mortality with Daratumumab-based frontline therapy in AL amyloidosis: A retrospective cohort study
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Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
pubmed.ncbi.nlm.nih.gov
Aggregation of antibody light chain proteins is associated with the progressive disease light chain amyloidosis. Patient-derived amyloid fibrils are formed from light chain variable domain residues...
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Current and Evolving Multimodality Cardiac Imaging in Managing Transthyretin Amyloid Cardiomyopathy
pubmed.ncbi.nlm.nih.gov
Amyloid transthyretin (ATTR) amyloidosis is a protein-misfolding disease characterized by fibril accumulation in the extracellular space that can result in local tissue disruption and organ dysfunc...
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Dual AApoAIV amyloidosis and ATTR amyloidosis arising in the same patient: a report of three cases
pubmed.ncbi.nlm.nih.gov
Dual AApoAIV amyloidosis and ATTR amyloidosis arising in the same patient: a report of three cases
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The importance of pathways to facilitate early diagnosis and treatment of patients with cardiac amyloidosis
pubmed.ncbi.nlm.nih.gov
Cardiac amyloidosis (CA) is a condition caused by extracellular deposition of amyloid fibrils in the heart. It is an underdiagnosed disease entity which can present with a variety of cardiac and...
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Heart of the Matter: Decoding the Underdiagnosed Cardiac Amyloidosis
pubmed.ncbi.nlm.nih.gov
Cardiac amyloidosis, a rare disorder marked by toxic amyloid protein deposition in the myocardium, contributes significantly to restrictive cardiomyopathy. We present an 85-year-old female diagnosed...
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A proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis
pubmed.ncbi.nlm.nih.gov
The mechanisms of tissue damage in kidney amyloidosis are not well described. To investigate this further, we used laser microdissection-mass spectrometry to identify proteins deposited in amyloid...
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Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis
pubmed.ncbi.nlm.nih.gov
Sporadic cases of apolipoprotein A-IV medullary amyloidosis have been reported. Here we describe five families found to have autosomal dominant medullary amyloidosis due to two different pathogenic...
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Health care resource use, diagnostic delay and disease burden in transthyretin amyloid cardiomyopathy in Sweden
pubmed.ncbi.nlm.nih.gov
Advanced ATTR-CM stages are associated with significant healthcare costs, as patients more often require resource-intensive inpatient care. The current diagnostic trajectory of ATTR-CM in this study...
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Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
pubmed.ncbi.nlm.nih.gov
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
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Diagnostic value of papillary muscle hypertrophy and mitral valve thickness to discriminate cardiac amyloidosis and Fabry disease
pubmed.ncbi.nlm.nih.gov
Our results suggest that the assessment of mitral valve thickness may be a new useful echocardiographic parameter to differentiate CA and FD, whereas papillary muscle hypertrophy and PM/LV-ratio...
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False Positive in [99mTc]Tc-DPD Scintigraphy for Cardiac Amyloidosis Due to Intravenous Iron Administration
pubmed.ncbi.nlm.nih.gov
[ 99m Tc]Tc-DPD (3,3-diphosphono-1,2-propanodicarboxylic acid) scintigraphy is an essential tool for diagnosing transthyretin amyloid cardiac amyloidosis. An 86-year-old woman suffering from heart...
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Practical Guidance for the Use of Patisiran in the Management of Polyneuropathy in Hereditary Transthyretin-Mediated Amyloidosis
pubmed.ncbi.nlm.nih.gov
Variant transthyretin amyloidosis (ATTRv) is an autosomal dominant inherited genetic disorder that affects 5000-10,000 people worldwide. It is caused by mutations in the transthyretin (TTR) gene and...
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Evaluation of peripheral nerve involvements in patients with familial Mediterranean fever
pubmed.ncbi.nlm.nih.gov
We detected that the prevalence of carpal tunnel syndrome in our patient population (13.04%) was higher than in the general population. Most of the changes in the range of parameters of SSR and RRIV...
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Patterns of gastrointestinal injury in patients with chronic kidney disease: Comparison of cases with and without sevelamer crystals
pubmed.ncbi.nlm.nih.gov
GI injury in CKD patients in both groups had similar features regardless of presence of sevelamer, suggesting that it adheres to tissue rather than causes injury. The study highlights other histolo...
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