Out today in @JACCJournals & #AHA25, led by @PabloMikiMarti Auto-MACE: automated AI adjudication model for MACE (CV death, MI, & stroke) Strong agreement with CEC in PARADISE-MI trial. Recognizes uncertain events. https://t.co/xkutUpIdBj

👉AMI-CS → abrupt, ischemic, forward failure = sequential shock 👉ACHF-CS → subacute, congestive, inflammatory = venous congestion & microvascular dysfunction precede collapse = Primed shock @JasonKatzMD @ShashankSinhaMD @Gurleen_Kaur96 @CardioNerds @CCCTNetwork

Excited to share our new paper in @JACCJournals . HF-CS needs to be thought about differently from AMI shock - it’s a primed, multisystem syndrome, not just pump failure. Full paper: https://t.co/yhUIHsQ67v. Would love to hear thoughts!

🫀 transplantation has evolved at an unprecedented pace in the past decade. Here is a 1-🛑-shop to reviewing all the latest advancements, current challenges in decision-making & what's on the horizon. @JCardFail @EricTopol @EricAdler17 @preventfailure @HFSA @NutritionHF

Incredible trifecta by #JohnOstrominski in @JACCJournals w #ESCCongress John is a one-of-a-kind talent, blending his joint CV & obesity fellowships, to lead a career in #CKM investigation. One to watch! 🚀 https://t.co/8u5ebXU5q7 https://t.co/3O4njKwSwk https://t.co/kPC5KFpX25

🚨 Now available open access for a limited time in @JCardFail - grateful to @dranulala & @robmentz for making this possible. We’d love your thoughts & feedback: 🔗 https://t.co/7l9KcmpDW2

Honored to be part of 4 new CSWG reports covering the full spectrum of MCS: 🔹 VA-ECMO: https://t.co/g5olSsWp5T 🔹 Impella 5.5: https://t.co/eFtqHu6Z92 🔹 Impella CP: https://t.co/zcWfMB5xUn 🔹 IABP: https://t.co/JoHcvtDe3f More to come! @NavinKapur4 @JHMontfort10

Congratulations to @BrianBergmark of #MGBInterventionalCardiology for his presentation at ESC2025 of ESSENCE TIMI73b and simultaneous NEJM publication. His second first author NEJM paper (2 more than me for those counting). More to come from this IC/trialist star!

#HeartTransplant #LVAD #MCS #Innovation #TransplantSurgery #CardioTwitter

Grateful to our global team for a terrific international collaboration. These shifts - sequencing, preservation, donor expansion, precision IS, patient-centered metrics, and XenoHT - define the next era. Read the review 👉 https://t.co/UyZnnOqbve #ESC2025 #HeartFailure

6️⃣ XenoHT: Gene-edited pigs (α-Gal/CMAH/B4GALNT2 KO; human complement/coagulation genes) extend feasibility; infectious risk mitigated. Early human cases highlight immune hurdles.

5️⃣ Redefining success: Beyond short-term survival, focus shifts to long-term outcomes - quality of life, return to roles, and equity. Integrating PROMs into trials and SRTR-style reporting ensures metrics reflect what matters to patients across diverse populations.

4️⃣ Precision Immunosuppression: Move beyond routine biopsies—use dd-cfDNA, GEP, and CMR (edema/fibrosis; sens 93%, NPV 99%) for targeted surveillance. Novel regimens: belatacept (renal-sparing, monitor late rejection) and IL-6 axis trials underway.

3️⃣ Donor expansion: DCD now up to ~30% at some centers with 1- & 5-yr survival ≈ DBD; PGD rates halved with protocol refinement. HCV+ grafts safe with DAA therapy. Ethics/logistics demand clear policy; focus on utilization, not discard.

2️⃣ Organ preservation: Moving beyond static cold storage, novel strategies are redefining ischemic time thresholds and geographic boundaries.

1️⃣ Decision frameworks: We move from an “either/or” mindset to net life prolongation. Contemporary HM3 outcomes approach HT at 2-5 yr in selected patients - supporting individualized sequencing (transplant-first vs LVAD-first)

Thrilled to share our State-of-the-Art Review in @JCardFail - an international collaboration - released with #ESC2025. We outline 6⃣ paradigm shifts reshaping heart transplantation. Thread 🧵

What a fun and memorable day! So proud of our amazing graduates — no doubt they’ll thrive in the next chapter of their careers. This year’s celebration had it all: a stunning venue, a hilarious fellows roast video, and an unforgettable Evening Report by @DRBAHLER. 🎓🎉

@DRBAHLER @ShazliKhanMD @PragyaRanjan @DrFuisz @DrSubratDas @MahmoudSamyMD @TanyaSh112 @YerazKhachatoo1 You each took turns being the 99%. And that’s how fellowship is. Congratulations to a great class! See ya at the party! @WMCCardsFellows @TanyaSh112 @MahmoudSamyMD @SwatiChand_ @ameeshisath @ABaliMD

Highlights of #ISHLT2025 ⁦@WMCHealth⁩ Heart Failure Team and kind of reunion Masashi Kai from ⁦@BIDMCSurgery⁩ ⁦@ameeshisath⁩ ⁦@stephenpanmd⁩ ⁦@VasilikiGreg⁩