AKL Therapeutics
@aklrd_ltd
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Committed to transforming patient’s lives through innovation - harnessing nature to tackle devastating diseases. AKL Research & Development t/a as Therapeutics.
Stevenage
Joined June 2018
What Research Demonstrates About Ageing https://t.co/fFfjiORBtS
#CellularSenescence #Senescence#SenescentCells
medicalresearch.com
It’s not only biology that defines ageing. In fact, research shows mental and social health matter deeply too. Older adults who maintain strong social networks, pursue hobbies, and continue learning...
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Neutrophil membrane-camouflaged SiRNA nanoplatform targeting IL-33 attenuates #Osteoarthritis through autophagy-dependent #Senescence regulation https://t.co/EVqOOwDKUO
#OA #SenescentCells #CellularSenescence #KneeOsteoarthritis #KneeOA
link.springer.com
Journal of Nanobiotechnology - Osteoarthritis (OA) imposes a substantial health and economic burden globally. Currently, there is a lack of disease-modifying osteoarthritis drugs (DMOADs). This...
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Aging by the clock and yet without a program. The mechanisms of aging are becoming increasingly well mapped; however, there remains ongoing debate about the ultimate and proximate causes of aging https://t.co/xk69n2mO4x
#SenescentCells
#CellularSenescence #Senescence
nature.com
Nature Aging - Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair...
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Aging: the wound that never starts healing https://t.co/D0sVIDCoh5
#CellularSenescence #SenescentCells #Senescence
nature.com
Nature Communications - Aging is a complex process resulting in a decline in organ function. Here the authors proposes that chronic activation of tissue damage response mechanisms drives aging,...
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The Bidirectional Role of Obesity and Aging in the Pathogenesis of #Osteoarthritis: Molecular Mechanisms, Epigenetic Insights, and Therapeutic Implications https://t.co/wrRWBgjVet
#OA #Senescence #SenescentCells #CellularSenescence #KneeOA #KneeOsteoarthritis
dovepress.com
Exploring the bidirectional relationship between obesity and aging in the pathogenesis of osteoarthritis (OA), focusing on the underlying molecular mechanisms
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Gene expression composite scores of #CellularSenescence predict aging health outcomes in the Health and Retirement Study https://t.co/coZlJYNogc
#SenescentCells #Senescence
nature.com
Nature Communications - Cellular senescence is an underlying mechanism of aging. Among older Americans, higher expression of genes linked to cellular senescence is seen in women and those with...
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Chondrocalcinosis Linked to Higher Risk for Incident #KneeOsteoarthritis
https://t.co/JHwOt6t4YD
#KneeOA #Osteoarthritis #OA
rheumatologyadvisor.com
Data from 2 prospective cohort studies showed that chondrocalcinosis was significantly associated with increased odds of incident radiographic knee OA.
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Aging research is increasingly focused on proteins that regulate DNA repair, metabolism, cell survival and tissue renewal. Six of the most promising could help delay age-related decline https://t.co/CcXKfEEXYO
#SenescentCells #CellularSenescence #Senescence
technologynetworks.com
Aging research is increasingly focused on proteins that regulate DNA repair, metabolism, cell survival and tissue renewal. Six of the most promising could help delay age-related decline.
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Cementless robotic-assisted total knee arthroplasty with functional knee positioning provides high implant survival at a minimum follow-up of 2 years https://t.co/seKCEAa3fv
#KneeOsteoarthritis #KneeOA #Osteoarthritis #OA
researchgate.net
Request PDF | Cementless robotic-assisted total knee arthroplasty with functional knee positioning provides high implant survival at a minimum follow-up of 2 years | Introduction Cemented fixation...
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Recent episode of the Joint Action podcast, a special one as October 12 was #WorldArthritisDay
https://t.co/3NLE60BMKO
#KneeOA #KneeOsteoarthritis #OA #Osteoarthritis
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Efficacy of adding manual therapy to hip and knee exercises in patients with patellofemoral pain syndrome: a double-blinded randomized controlled clinical trial https://t.co/x27rTOQUtK
#OA #KneeOsteoarthritis #KneeOA #Osteoarthritis
nature.com
Scientific Reports - Efficacy of adding manual therapy to hip and knee exercises in patients with patellofemoral pain syndrome: a double-blinded randomized controlled clinical trial
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Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in #Osteoarthritis by integrating bioinformatics and machine learning https://t.co/0Op4v33PsJ
#KneeOA #KneeOsteoarthritis #OA
pubmed.ncbi.nlm.nih.gov
The results of screening Hub OA-ERDEGs using machine learning algorithms show that: TOLLIP, ALB, HP, RHOBTB3, GSTM2, S100A8 and AKR1B1 were significantly up-regulated or down-regulated in OA samples...
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Scientists have found the protein behind aging — and might be able to neutralize it https://t.co/NIhYP1NpQH
#Senescence #SenescentCells #CellularSenescence
futura-sciences.com
That idea just got a major boost. Scientists in South Korea have identified a molecule that seems to drive aging in the body. Even more exciting? They’ve found ways to potentially block it—paving the...
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How Cell Cycle Stages Influence Aging Cells’ Response to Senolytic Drugs https://t.co/gFR6NlPKvI
#Senescence #SenescentCells #CellularSenescence
bioengineer.org
In a groundbreaking study published in the August 2025 issue of Aging-US, researchers have unveiled new insights into the complexity of senescent cells and their varied responses to senolytic...
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Low-dose methotrexate fails to reduce #KneeOsteoarthritis pain, synovitis vs placebo https://t.co/FTcGR7gEBD
#Osteoarthritis #OA #KneeOA
healio.com
Low-dose methotrexate failed to improve on placebo in reducing pain or synovitis in patients with inflammatory knee osteoarthritis, according to findings published in JAMA Internal Medicine.“Inflam...
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Data-Driven Discovery Of #KneeOsteoarthritis Subgroups Via Cluster Analysis Of Mri Biomarkers https://t.co/f37t1Q0oE5
#KneeOA #Osteoarthritis #OA
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‘Artificial cartilage’ could improve arthritis treatment https://t.co/kEw5fwDMz7
#OA #Osteoarthritis #KneeOA #KneeOsteoarthritis
cam.ac.uk
The squishy material can be loaded with anti-inflammatory drugs that are released in response to small changes in pH in the body. During an arthritis flare-up, a joint becomes inflamed and slightly
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PRDM16 Reduces #CellularSenescence by Upregulating GSTM1 https://t.co/yBS3YyCyyU
#SenescentCells #Senescence
advanced.onlinelibrary.wiley.com
Cellular senescence drives aging and aging-related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss...
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Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine #Senescence in microglia - Nature Aging https://t.co/9s3M0JQdlL
#CellularSenescence #SenescentCells
nature.com
Nature Aging - Hu et al. identify border-associated macrophages as early targets of brain aging. These cells acquire senescence-associated properties, which are transmittable via migrasomes...
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Targeting #CellularSenescence for Healthy Aging: Advances in Senolytics and Senomorphics https://t.co/8K82YZBFFJ
#Senescence #SenescentCells
dovepress.com
Examining the processes of cellular senescence, its effects on aging and age-related disorders, and emerging therapeutic strategies to modulate senescence
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