Andrew Morgan, MD PhD
@_apm0
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clinical asst prof medicine UNC | via UNC MSTP, Duke medicine/pediatrics | evolution, genetics, mice
Chapel Hill, NC
Joined October 2014
Updated after review, with some additions to figures and discussion.
biorxiv.org
Meiotic recombination ensures the fidelity of chromosome segregation in most organisms with sexual reproduction. The distribution of crossovers along chromosomes is governed in part by interference,...
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Yet more niche meiosis-related results from old data: sex differences in escape from crossover interference in mice (short report) https://t.co/mbncXTBuBN
biorxiv.org
Meiotic recombination ensures the fidelity of chromosome segregation in most organisms with sexual reproduction. The distribution of crossovers along chromosomes is governed in part by interference,...
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Now out early online in Genetics (@GeneticsGSA): https://t.co/oi3JvXDJt3
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Now updated and revised (main conclusions unchanged) https://t.co/te9G3vAS4J
biorxiv.org
Meiotic recombination is required for faithful chromosome segregation in most sexually reproducing organisms and shapes the distribution of genetic variation in populations. Both the overall rate and...
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More niche meiosis-related results from old data: variation in strength of crossover interference in house mice https://t.co/y3vcwrK7Ks
biorxiv.org
Meiotic recombination is required for faithful chromosome segregation in most sexually reproducing or-ganisms and shapes the distribution of genetic variation in populations. Both the overall rate...
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A centralized resource for mouse population genomics: WGS data from 277 (and counting) published samples, aligned to the recent mm39 reference, available for download or compute via AWS S3 https://t.co/VLqFddWNn7
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Revised and improved version finally in "print" at Heredity; dataset available from Dryad https://t.co/jGZceaGPUV
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Similar to the 1K Genomes *.bam files for human genetics, on a smaller scale as usual. It would lower the barrier to data re-use
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For the mouse genetics people: would there be interest in creating a repository of available wild mouse genomes (now >200), all aligned against mm39?
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This work would not have been possible without the help of many collaborators over the years. Any comments, or pointers to relevant prior work that we have overlooked, are much appreciated.
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Much of this is well-trodden ground, but we think the findings regarding inbreeding are at least somewhat novel.
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... and use the length distribution of homozygous segments to learn about recent population demography.
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We find evidence of lots of inbreeding, especially in M. m. domesticus ...
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This project is more than 10 years in the making; a previous manuscript ( https://t.co/TLVV0uLs8o) stalled after several desk rejections.
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Population structure and inbreeding in house mice: our attempt to synthesize genotype data from >800 specimens. With @Jon_J_Hughes, @jdidion and others.
biorxiv.org
House mice ( Mus musculus ) have spread globally as a result of their commensal relationship with humans. In the form of laboratory strains, both inbred and outbred, they are also among the most...
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This was 'first wave' and patients were quite sick (overall 28-day mortality 27%), but still hard to tell if more heparin had net benefit. Fortunately RCTs underway elsewhere (2/2)
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Brief report on the early experience with COVID at Duke, focused on the dilemma of how aggressively to anticoagulate (1/2) https://t.co/rdWfjtuZLK
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