Bae Mechanobiology and Mechanomedicine Lab
@YonghoBae2
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We aim to understand the impacts and molecular mechanisms by which changes in arterial stiffness influence the biology and mechanics of smooth muscle cells.
Buffalo, NY
Joined July 2019
I am delighted to share our new publication in Cytoskeleton, led by Bat-Ider Tumenbayar and Khanh Pham, featuring our RNAseq data that uncovers the mechanobiological roles of FAK and p130Cas in early transcriptional regulation and biological processes.
onlinelibrary.wiley.com
Cellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate...
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I am pleased to share our latest study on cell motility, led by Thomas Mousso and Kalina Rice, titled "Survivin modulates stiffness-induced vascular smooth muscle cell motility.".
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Delighted to share our new study in Cytoskeleton, led by Bat-Ider Tumenbayar & Khanh Pham, featuring our RNAseq data that uncovers the mechanobiological roles of FAK & p130Cas in early transcriptional regulation and biological processes.
onlinelibrary.wiley.com
Cellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate...
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Congratulations, Thomas Mousso, on successfully passing your qualifying exam! You are now officially a PhD candidate.
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Two PhD students, Rhonda Drewes and Thomas Mousso, from the Bae Lab will be giving podium presentations at the Biomedical Engineering Society (@BMESociety) meeting in Baltimore. Please stop by and check out our latest studies!
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I am excited to share our latest genomics study, titled "Transcriptomic and multi-scale network analyses reveal key drivers of cardiovascular disease"
biorxiv.org
Cardiovascular diseases (CVDs) and pathologies are often driven by changes in molecular signaling and communication, as well as in cellular and tissue components, particularly those involving the...
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RT @aplbioeng: I'm a Survinin! New @APLBioeng paper from @YonghoBae2 and @UB_BME reveals survivin's impact on the modulation of cell phenot….
pubs.aip.org
Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease and a key risk factor for cardiovascular disease events. The in
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Today, I've been promoted to a tenured Associate Professor. I deeply appreciate my students, collaborators, mentors, family, and friends for their support.
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Excited to share that my tenure dossier got approved by the University at Buffalo (UB) President, making me a tenured Associate Professor at UB. Grateful to my past and present students, collaborators, and friends for their support.
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Excited to share our latest genomics work! "FAK and p130Cas modulate stiffness-mediated early transcription and cellular metabolism"
biorxiv.org
Cellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals about substrate stiffness...
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Three lab members presenting at @ASCB meeting #cellbio2023 in Boston. Stop by and check them out!
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RT @musclecellnews: Dr. Yongho Bae (@YonghoBae2) and team show that survivin is necessary for vascular smooth muscle cell cycling 🚴 and pro….
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"Survivin as a Mediator of Stiffness-Induced Cell Cycle Progression and Proliferation of Vascular Smooth Muscle Cells" has been published in APL Bioengineering, revealing survivin's impact on the modulation of cell phenotype & proliferation.
pubs.aip.org
Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease and a key risk factor for cardiovascular disease events. The in
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I'm pleased to announce that "Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells" is published in APL Bioengineering. Here, we show how ECM stiffness affects cellular tension and ECM synthesis.
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Our co-authored paper, with Dr. Szigeti lab, has been published in eBioMedicine. Congrats to Szigeti & my students Yuna & Erik! I am happy our contributions to this paper, including research on lamellipodin, Rac, mechanotransduction, hydrogels, & AFM, have made a valuable impact.
3rd highlight of our Sep issue. Neuronal actin cytoskeleton gain of function in the human brain. K Szigeti et al from @SUNY explored the physiological role of CHRFAM7A in human brain using multiomics approach on 600 post mortem brain tissue samples. Read
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Our paper, entitled "Key role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3" with Dr. Assoian lab has been accepted for publication in the Journal of Cell Science. Congrats to Irene & Joe !!!.
journals.biologists.com
Summary: Rac plays a major role in the initial transcriptional response to extracellular matrix stiffness and mediates the stiffness-dependent repression of ATF3, resulting in the induction of cyclin...
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The Department of Pathology and Anatomical Sciences in the Jacobs School of Medicine at the University at Buffalo is currently seeking to hire a tenure-track Assistant or Associate Professor (Computational Anatomist). Applicants may apply at
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Congratulations to my student, Kalina Rice, on successfully defending her MS thesis. It could have significant implications in the field of mechanobiology and vascular smooth muscle cell biology. Well done!!!
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