a few years back @RuiMoreira_UL encouraged me to join this social media platform. I see more and more scientists leave here, and I will also from now on be posting at bluesky.

Congrats to all authors, especially to first author Shanping Ji. Also thanks to @KvidoStrisovsky , Martin Lepsik @Lepsik_science and @RuiMoreira_UL for the collaboration.

In this paper, we screened a variety of reactive electrophiles, including peptidyl chloromethyl ketones, phosphonate and phosphinate esters, and oxo-beta-lactams. We found that oxo-beta-lactams display submicromolar activity & provide a computational structural model of binding.

Please check out our most recently accepted paper on oxo-beta-lactams as inhibitors for the human intramembrane protease PARL. Note that this will likely be my last post on X. Please join me at bluesky!

I see less and less scientist here. Where have they gone? Mastodon? Bluesky? Something else? What is the recommended platform?.

I am ending this thread with a quote of Charles Bukowski, one of my favorite authors: “We are here to drink beer. We are here to kill war. We are here to laugh at the odds and live our lives so well that Death will tremble to take us.”.

There is only one planet. There is only one life to live. Live it well, and keep the planet and human society well for the next generation.

Truth and reality are increasingly getting distorted by opinions, fake news and people that want to polarize instead of unite society. I think that social media is definitely a contributing factor to this - and what do those in charge of the social media companies do about this?.

Still, the majority of Americans who casted their vote, voted for trump. What does this tell us about democracy? What does this tell us about the interest of voters in politics, in the actual policy of the candidate and its effect on society and international community?.

But you don't need to be a scholar to see that he makes false statements, has promoted conspiracy theories, makes racist and misogynistic remarks, and has been involved in various trials including for sexual harassment.

Trump ranks amongst the 5 worst presidents in terms of abilities and accomplishments (according to surveys amongst historians and presidential scholars).

I'm on X to promote science, and I generally do not mix in other discussions. But today I am just confused. How can it be that Donald Trump was re-elected president?.

Are you looking for a PhD position in medicinal chemistry/chemical biology? This may be interesting for you!.

I am happy to announce that I was promoted to full professor in Chemical Biology. I hope to continue to contribute to the field of chemical probe development, mentor my co-workers to the best of my ability and teach in stimulating and innovative ways to undergraduate students.

A delayed Tweet: about 2.5 weeks ago, some of my lab members and I participated in the 10k University Trail run of KU Leuven. In another 2.5 weeks I hope to finish my first full marathon. Keep moving your borders, and stay healthy!

Thanks to external jury members Michael Guetschow, Pieter Van Der Veken @PieterVdVeken, internal members Peter Verwilst @MedChemVerwilst and Wim Dehaen, and chairman Rudi Vennekens.

Yesterday, my 13th PhD student, Shanping Ji, successfully defended his PhD. His work dealt with inhibitors and activity-based probes for rhomboid proteases and proprotein convertases.

RT @ChemBioChem: 📢 Make sure not to miss the 4th Virtual @ChemBioTalks. Register now for free: 🗓️ September 24, 20….

My lab has an open post-doc position in Organic Synthesis & Chemical Biology with a focus on membrane proteins in synapses. Apply before the end of August 2024. See:

As a thank you for my recent efforts as a jury member for BSc thesis defenses at the university of applied sciences UC Leuven Limburg, I received this Malbec-shiraz, which I now enjoy while baking focaccia on my new pizza stone. Enjoy the small benefits of academia!