Our new manuscript is online! .Cas9 nickase-mediated contraction of CAG/CTG repeats at multiple disease loci. Giant team effort! Led by the incredible @Alvaro_MurilloB with more help from @mariahlelos, @lab_davidson, and many many more. Here's a thread.

We are lucky to be among the funded projects (We’re in good company!). We’re de-risking our gene editing approach for expanded repeat disorders (e.g. Huntington’s disease, myotonic dystrophy…). One step closer to the clinic!

RT @nlconnor_robson: Are you a bioinformatician interested in neurodegeneration? If so we have an exciting opportunity for you to join the….

If you are from abroad and/or you have already been thinking of leaving, this is a good push. But for the vast majority of people, going abroad is not a solution.

3) There are not enough science jobs for hundreds of Americans to suddenly go abroad. 4) This is a grass is greener on the other side idea. There are problems with the systems elsewhere also.

2) Getting funding in another country’s funding system is not trivial. NIH-style grant is not the same as MRC or CIHR grants. The cultures, reviewers, and expected preliminary data are all different. It’s a new skill to learn.

1) It is incredibly hard to move countries, you lose your social circle and you uproot your kids/partner who also have local lives/jobs/studies.

I’ll say it again because it is important. American scientists will not en masse leave the US. This is for several reasons. Here are a few. For those already on the fence, we are recruiting a new centre director.

I did a podcast. On #huntingtonsdisease. And #geneediting. So have a listen! .

I’ll drop this link her for anyone fancying being recruited as the new centre director for the @UKDRI at Cardiff uni.

Alright people, we need a new director. We’re a fun bunch and we do outstanding science. #neurodegeneration #PD #Huntington #Alzheimers . For more info, see link below and/or DM me! . @UKDRI @neurosciencecu .

RT @Alvaro_MurilloB: I am very honored to speak at the Xmas meeting at the @InstitutoCajal in the new @Ci2A_CSIC about the research we cond….

RT @Alvaro_MurilloB: Looking forward to talking about my work at @VDion_and_Lab and meet fantastic researchers at @UBneuroscience.@HDAwaren….

RT @Alvaro_MurilloB: Looking forward to presenting my Pilot Grant project at @UKDRI Connectome. Many thanks to @VDion_and_Lab for his suppo….

RT @maria_spies: An important and exciting step towards counteracting DNA repeat expansions in clinical setting. Read the new Editor's choi….

Correct link:.

Our article on how Cas9 nickase induces contraction of expanded CAG repeats is published! . Go on, read it, you know you want to. One step closer to the clinic! (But still some ways to go…) .

RT @TomeStephanie: Our preprint is online. CCG interruptions are unstable and hypermethylated in DM1 patients. A….

RT @TomeStephanie: Great program with international speakers 🇨🇵🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧🇺🇸🇸🇪.Day 1.Yoan Lassalle @TwistBioscience.Sarah Cumming @UofGlasgow….

Also it was a very smooth process at this new journal, thanks to @maria_spies ! I would recommend it to friends.

New manuscript! . We can contract expanded CAG/CTG repeats in non-dividing cells using the Cas9 nickase and transcription promotes contractions! . This answers some big questions about how contractions can be harnessed for the therapeutic use!.