We would like also to thank all the residents who hosted the large number of candidates interested in @UPMCPath and had a major effect on the success of this year’s match @UPMCPathology

Here is the link for the case: .

These findings suggest the diagnosis of a CD20+ small B-cell lymphoma with plasmacytic differentiation (IgM-lambda), likely marginal zone lymphoma with associated tri-clonal gammopathy.

FISH studies showed del7q, translocation between the long arms of Ch 4 and 11, and deletion of the long arm of the derivative Ch 11 (partial monosomy 11q). NGS revealed mutations involving DNMT3A and KLF2 genes.

Flow cytometry showed an abnormal lymphoid population positive for CD19, CD20, CD45, and lambda and negative for CD5, CD10, CD11c, CD103, CD123, and kappa. CD38 was variably positive, with a subset bright positive, and CD13 and CD33 were partially dim positive.

Lambda light chain was elevated with a free kappa/lambda ratio of 0.13. A bone marrow biopsy demonstrated hypercellularity and extensive infiltration by abnormal lymphocytes.

CP case of the month 🔬:.A man in his 70's presented with pancytopenia, weight loss, and lymphadenopathy. He was found to have elevated creatinine (1.7 mg/dL), elevated IgM (582 mg/dL), normal IgA, and slightly depressed IgG. Immunofixation showed the following:

Diagnosis: Mixed carcinoma in situ: Pleomorphic lobular carcinoma in situ (P-LCIS), with ductal carcinoma in situ (DCIS), nuclear grade 2-3, cribriform type with apocrine differentiation, comedonecrosis, and calcifications.

An E-cadherin stain demonstrated the following patterns: Which is the most likely diagnosis?

AP case of the month:.A female in her 60's is found to have a hypoechoic breast lesion with calcifications. Core biopsy showed the following 👇

RT @UPMCPathology: Great insights from @UPMCpathology’s Dr. Lakshmi Harinath, MD, MPH, at the 22nd International Congress of Cytology in Fl….

RT @UPMCPathology: Dr. Hooman Rashidi, Executive Vice Chair of #Computational Pathology @UPMCPathology presented the @PittTweet's School of….

RT @UPMCPathology: The future of urine #CytoPath; Dr. Sigfred Lajara of @UPMCPathology presenting “@TheAixMed: Enhancing Diagnostic Accurac….

RT @UPMCPathology: At #ASCCP2025 in San Diego, Dr. Chengquan Zhao of @UPMCpathology presented: Assessment of Efficiency and Accuracy of AI….

RT @UPMCPathology: @PittTweet and @LeidosInc are joining forces to drive the future of #AI in medicine, led by Dr. Hooman Rashidi at the he….

Years later, the patient required surgery. Platelet aggregation study results were similar to before. Granule storage and release testing by flow cytometry demonstrated decreased delta and alpha granule release upon stimulation with thrombin receptor agonist and ADP. Diagnosis?

Platelet aggregation studies by light transmittance aggregometry on platelet rich plasma were abnormal in response to ADP only. Adenine nucleotide testing for delta-storage pool deficiency was normal. A platelet function defect was diagnosed, unclear if inherited or acquired.

@UPMCPath case of the month:.A woman with increased mucocutaneous bleeding symptoms, perioperative bleeding requiring blood transfusion, and family history of easy bruising has normal lab workup (CBC, peripheral blood film, PT, aPTT, von Willebrand profile and closure times).

The correct diagnosis is subacute sclerosing panencephalitis (SSPE): a rare complication of measles infection that can present with absence of immunohistochemically detectable measles antigen usually years after an initial infection in patients with intact immune systems.

@UPMCPath jeopardy team at Pennsylvania Association of Pathology Annual Meeting 2025! @HaleyCorbin7

Brain biopsy 🔬: Gliotic & edematous parenchyma w/ eosinophilic nuclear inclusions in oligodendrocytes (A); multinucleation (B); lymphocytes; EM w/ oligodendrocyte cytoplasmic inclusions/chromatin remodeling (C); RNAscope strong + staining for measles virus RNA (D). Diagnosis?