@UniOslo_MED @YaleSPH @LancetCountdown.

Please join us for the Norway launch of the Lancet Countdown on Health and Climate Change this Thursday. Can be followed on Zoom. I'll present on the impact of heat on pregnancy outcomes and child health.

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RT @YaleSPH: Researchers from the Yale School of Public Health have studied how rising temperatures adversely affect human health. A new st….

RT @jeffgoodell: "[During the eighth week of pregnancy], a mean weekly temperature of 30 degrees C (86 degrees F) was associated with an al….

Ambient heat during pregnancy linked to increased risk of childhood cancer via @YaleSPH.

RT @TheLancetPlanet: Read our new July issue here:

3) At the population level, our findings add considerably to the field of climate change and pregnancy health. Not only does heat exposure have immediate negative effects on pregnancy (e.g., preterm birth), but there may be long-term consequences for the offspring. 11/11.

2) Fortunately, childhood ALL is very rare. At the individual level, it is highly unlikely that exposure to heatwaves will cause childhood ALL. Likewise, it is unlikely that a given child with ALL can trace the "cause" back to exposure to high temperatures in fetal life. 10/11.

Some concluding thoughts: 1) This is the first study to evaluate the association between high ambient temperatures and childhood ALL. While we consider our analyses to be robust and supporting our a priori hypothesis, our findings should be evaluated in other datasets. 9/11.

We also constructed a secondary matched dataset. This differed from the primary matched dataset by matching on residential address (<10 km) and year of conception instead of date of LMP. The analysis supported the main analysis. 8/11

The analyses supported our hypothesis. In other words, high ambient temperatures in the first trimester were associated with an increased risk of childhood ALL. 7/11

Linking birth records to cancer registry in California 1982-2015, we matched 6,258 cases to 307,579 controls on sex, race, ethnicity and date of last menstrual period (+/- 7 days). Therefore, the cases and matched controls were at the same pregnancy stage at the same time. 6/11.

Based on tangential evidence, we drew the following figure of the hypothesized association between high ambient temperatures and risk of childhood ALL. This figure was created before we had the temperature data and before we had started any of the analyses. 5/11

Why early pregnancy? Embryonic/fetal tissues are most vulnerable when they are nascent. Lymphopoiesis starts around week 8, so we suspected exposure in this period to be most important. This is also supported by studies of ALL and other environmental exposures. 4/11.

Why this study? Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the incidence is increasing. We know that ALL has a prenatal onset. For instance, children who are diagnosed with ALL have pre-leukemic cells present at the time of birth. 3/11.

This was an exceptional team effort with colleagues at Yale School of Public Health, University of Southern California and UC Berkeley. @YaleSPH @Yale @KeckMedicineUSC @UCBerkeley @ChenKai_yale @DezielLab_yale @pinw59 R Wang, C Metayer, J Wiemels, J Warren and X Ma. 2/11.

Excited to see our paper out in @TheLancetPlanet . We observed that exposure to high ambient temperatures in early pregnancy was associated with an increased risk of childhood acute lymphoblastic leukemia. More details follow 🧵 1/11.

RT @ChenKai_yale: Glad to share our new paper @TheLancetPlanet led by @TormodRogne @YaleSPH, funded by our @CCHYale Pilot Award. Ambient #….

🎓 My first commencement in the US. What a lovely day!. #Yale2024 @YaleSPH

@haoran_yale.