The Zia Lab
@TheZiaLab
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The Zia Lab builds whole-cell models of biological cells, large-scale computational models of gels and other soft matter, via integrated multi-scale modeling.
University of Missouri
Joined May 2022
Excited to present our work on whole-cell modeling of E. coli and ribogenesis in at the @AmerChemSociety Fall 2025 Meeting! Great work from ZiaLab members Vishal Sivasankar, Jen Hofmann and Theo Yang. Come check it out at the Westin Potomac Salon 3, Monday 08/18 at 8:00AM!
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Excited to share new work now out in @NatureComms Biology! We use computational modeling to show how E. coli preloads its ribosomes to speed codon recognition testing & protein synthesis for faster growth. Check out the paper (open access) at
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Excited to present NEW WORK at APS! The ZiaLab is headed to the 2025 @APSphysics Global Summit! Catch Vishal Sivasankar as he presents our latest work on whole-cell modeling of Escherichia coli. Donโt miss it! #APSMarch #APSSummit25
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Paper now out in PNAS! Our colloidal whole-cell simulations + in vivo 3D particle tracking reveal how macromolecular interactions and confinement determine dynamics/localization in E. coli. Congrats @AlpSunol & @dsvalverdem!ย
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Excited to share our accepted Annual Reviews article, "The matter/life nexus in biological cells". We cast a wide net into cellular biology, biophysics, and genetic approaches to defining life, toward understanding of the materiality of cellular life:
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Check out our expanded model for Confined Stokesian dynamics with novel functions for rheology, just published in @JFluidMech. Check out the paper at
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๐ฃ๐ต๐๐๐ถ๐ฐ๐ย ๐ผ๐ณย ๐น๐ถ๐ณ๐ฒ: We are excited to share our new preprint on 3D diffusion in liveย E. coli where we show how colloidal physics regulate life-essential processes in biological cells. Check out the paper and video at
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Come see our talk at ICR on Friday at 11:50 with exciting results about two step yield in colloidal gels!.
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We show that all gels incorporate three mechanisms of gel solidification: percolation, phase separation, and glassy arrest. Extracting the minimal thermodynamic conditions of forming gels from experiments or simulations, we construct a phase diagram for gel morphologies.
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Exciting news! Brian's work to elucidate "Minimal conditions for solidification and thermal processing of colloidal gels" is published in PNAS! It is a fantastic collaboration with @theHelgesonLab Check the paper out here:
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11:30 AM at APS, join us for an exciting session: .โNew physics based perspectives in building and understanding biological cellsโ.Access ROOM 238 via ROOM 205! . invited speakers are Roseanna Zia, @KateAdamala , John Glass, Roseanna Zia , Antonio Calavera, Sumitaba Brahmachari.
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The Zia Lab is hiring! Postdocs and Grad Students are needed for new Sloan Foundation Grant aimed at modeling the colloidal physics that instantiates life itself in the minimal biological cell. Details can be found here:
sloan.org
Our mission is to make the world a better place through the advancement of scientific knowledge.
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Exciting news! @AlpSunol has published his work "Confined Brownian suspensions: Equilibrium diffusion, thermodynamics, and rheology" in Journal of Rheology! Please find it here:
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We are excited to share the publication of our work "Colloidal Physics Modeling Reveals How Per-Ribosome Productivity Increases with Growth Rate in Escherichia coli" in mBio. Congrats to Akshay and the rest of the team! Check it out at
journals.asm.org
Ribosomes are the factories in cells that synthesize proteins. When cells grow faster, there are not enough ribosomes to keep up with the demand for faster protein synthesis without individual...
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๐ฃ๐ต๐๐๐ถ๐ฐ๐ ๐ผ๐ณ ๐น๐ถ๐ณ๐ฒ: We are excited to share our recent work investigating how ultra-weak protein-protein interactions can modulate behavior in the cytoplasmic proteome of ๐. ๐จ๐ฆ๐ฏ๐ช๐ต๐ข๐ญ๐ช๐ถ๐ฎ.
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We show that neither ribosome abundance nor chemistry alone are sufficient to explain speedup; rather, physical transport dominates translation rate (80%) over chemistry (20%) via a combinatoric proximity mechanism.
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We model mRNA translation in E. coli by explicitly representing physical and chemical interactions between explicitly represented translation molecules, Brownian motion, and reactions.
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๐ฃ๐ต๐๐๐ถ๐ฐ๐ ๐ผ๐ณ ๐น๐ถ๐ณ๐ฒ: We are excited to share our recent work showing colloid physics speed up protein synthesis to drive faster growth in E. coli: โMolecular transport and packing underlie increasing ribosome productivity in faster growing cellsโ
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Panta Reรญ at USNCTAM #fluidmechanics @SoRheology @a_grillet @theHelgesonLab @GrahamFluidDyn @garethmckinley @TheSquishyLab @SafaJamali
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